RESEARCH ARTICLE
Two-Photon Polymerizable Nanocomposites Incorporating Brazilian Red Propolis for Tailored Wound Healing Applications
Laura M. S. Santos,
Jonathas M. Oliveira,
Laís F. A. M. Oliveira,
José M. S. Oliveira,
Ingrid F. Leite,
Alcenísio J. Jesus-Silva,
Glauber T. Silva,
Eduardo J. S. Fonseca,
Laura M. S. Santos
Optics and Nanoscopy Group, Institute of Physics, Federal University of Alagoas (UFAL), Maceió, Brazil
Search for more papers by this authorJonathas M. Oliveira
Federal Institute of Alagoas (IFAL), Coruripe, Brazil
Search for more papers by this authorLaís F. A. M. Oliveira
Optics and Nanoscopy Group, Institute of Physics, Federal University of Alagoas (UFAL), Maceió, Brazil
Search for more papers by this authorJosé M. S. Oliveira
Postgraduate Program in Health Research, Cesmac University Center, Maceió, Brazil
Search for more papers by this authorIngrid F. Leite
Postgraduate Program in Health Research, Cesmac University Center, Maceió, Brazil
Search for more papers by this authorAlcenísio J. Jesus-Silva
Optics and Nanoscopy Group, Institute of Physics, Federal University of Alagoas (UFAL), Maceió, Brazil
Search for more papers by this authorGlauber T. Silva
Physical Acoustics Group, Institute of Physics, Federal University of Alagoas, Maceió, Brazil
Search for more papers by this authorCorresponding Author
Eduardo J. S. Fonseca
Optics and Nanoscopy Group, Institute of Physics, Federal University of Alagoas (UFAL), Maceió, Brazil
Correspondence:
Eduardo J. S. Fonseca ([email protected])
Search for more papers by this authorLaura M. S. Santos,
Jonathas M. Oliveira,
Laís F. A. M. Oliveira,
José M. S. Oliveira,
Ingrid F. Leite,
Alcenísio J. Jesus-Silva,
Glauber T. Silva,
Eduardo J. S. Fonseca,
Laura M. S. Santos
Optics and Nanoscopy Group, Institute of Physics, Federal University of Alagoas (UFAL), Maceió, Brazil
Search for more papers by this authorJonathas M. Oliveira
Federal Institute of Alagoas (IFAL), Coruripe, Brazil
Search for more papers by this authorLaís F. A. M. Oliveira
Optics and Nanoscopy Group, Institute of Physics, Federal University of Alagoas (UFAL), Maceió, Brazil
Search for more papers by this authorJosé M. S. Oliveira
Postgraduate Program in Health Research, Cesmac University Center, Maceió, Brazil
Search for more papers by this authorIngrid F. Leite
Postgraduate Program in Health Research, Cesmac University Center, Maceió, Brazil
Search for more papers by this authorAlcenísio J. Jesus-Silva
Optics and Nanoscopy Group, Institute of Physics, Federal University of Alagoas (UFAL), Maceió, Brazil
Search for more papers by this authorGlauber T. Silva
Physical Acoustics Group, Institute of Physics, Federal University of Alagoas, Maceió, Brazil
Search for more papers by this authorCorresponding Author
Eduardo J. S. Fonseca
Optics and Nanoscopy Group, Institute of Physics, Federal University of Alagoas (UFAL), Maceió, Brazil
Correspondence:
Eduardo J. S. Fonseca ([email protected])
Search for more papers by this authorFirst published: 17 July 2025
Funding: This work was supported by the Fundação de Amparo à Pesquisa do estado de Alagoas—FAPEAL (APQ2019041000017), the Conselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq, and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Finance Code No. 001).
ABSTRACT
This study introduces novel nanocomposites incorporating Brazilian red propolis (RPNP) into acrylic resins, designed for advanced wound dressing applications. The nanocomposites exhibit enhanced mechanical properties, including increased flexibility and reduced elastic modulus, along with potent antimicrobial activity, particularly against Staphylococcus aureus. The ability to customize drug release profiles—tuning the polymeric compounds of the nanocomposite—offers versatile treatment options for various wound conditions. Spectroscopic and FTIR analyses confirmed the presence of bioactive phenolic compounds, such as naringenin, which contributes to the antimicrobial efficacy of the materials. Additionally, Two-Photon Polymerization enabled the creation of customizable microarchitectures, supporting cell adhesion, proliferation, and differentiation, further promoting wound healing. These features, coupled with the bioactivity of Brazilian red propolis, position the nanocomposites as promising platforms for wound care, combining infection control with enhanced healing. Future research will focus on clinical trials and the further refinement of these materials for broader biomedical applications.
Graphical Abstract
Nanocomposites combining Brazilian red propolis nanoparticles with acrylic resins exhibit controlled nanoparticle release, good flexibility, and antibacterial activity against Staphylococcus aureus. Moreover, these materials are highly suitable for the fabrication of cellular scaffolds via two-photon polymerization, making them strong candidates for advanced wound dressing applications.
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