AAPM&R consensus guidance on spasticity assessment and management
Corresponding Author
Monica Verduzco-Gutierrez MD
Department of Rehabilitation Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Correspondence
Monica Verduzco-Gutierrez, Department of Rehabilitation Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Email: [email protected]
Search for more papers by this authorPreeti Raghavan MD
Department of Physical Medicine and Rehabilitation and Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Search for more papers by this authorJessica Pruente MD
Department of Physical Medicine & Rehabilitation, University of Michigan, Ann Arbor, Michigan, USA
Search for more papers by this authorDaniel Moon MD, MS
Department of Physical Medicine and Rehabilitation, Jefferson Moss-Magee Rehabilitation Hospital, Elkins Park, Pennsylvania, USA
Search for more papers by this authorCassandra M. List MD
Brooks Rehabilitation Hospital, Jacksonville, Florida, USA
Search for more papers by this authorJoseph Edward Hornyak MD, PhD
Department of Physical Medicine & Rehabilitation, University of Michigan, Ann Arbor, Michigan, USA
Search for more papers by this authorFatma Gul MD, MS
Department of Physical Medicine and Rehabilitation Department, University of Texas, Southwestern Medical Center, Dallas, Texas, USA
Search for more papers by this authorSupreet Deshpande MD
Department of Pediatric Rehabilitation Medicine, Gillette Children's Hospital, St.Paul, Minnesota, USA
Department of Rehabilitation Medicine, University of Minnesota, Minneapolis, Minnesota, USA
Search for more papers by this authorSusan Biffl MD
Division Pediatric Rehabilitation Medicine Department of Orthopedic Surgery, UCSD Rady Children's Hospital, San Diego, California, USA
Search for more papers by this authorZainab Al Lawati MD, MEd, FRCPC, FAAPMR
Department of Rehabilitation Medicine, University of Minnesota, Minneapolis, Minnesota, USA
Search for more papers by this authorAbraham Alfaro PhD, DO
Rehabilitation Medicine, AtlantiCare Health Services, Inc., Federally Qualified Health Center (FQHC), Atlantic City, New Jersey, USA
Search for more papers by this authorCorresponding Author
Monica Verduzco-Gutierrez MD
Department of Rehabilitation Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Correspondence
Monica Verduzco-Gutierrez, Department of Rehabilitation Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Email: [email protected]
Search for more papers by this authorPreeti Raghavan MD
Department of Physical Medicine and Rehabilitation and Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Search for more papers by this authorJessica Pruente MD
Department of Physical Medicine & Rehabilitation, University of Michigan, Ann Arbor, Michigan, USA
Search for more papers by this authorDaniel Moon MD, MS
Department of Physical Medicine and Rehabilitation, Jefferson Moss-Magee Rehabilitation Hospital, Elkins Park, Pennsylvania, USA
Search for more papers by this authorCassandra M. List MD
Brooks Rehabilitation Hospital, Jacksonville, Florida, USA
Search for more papers by this authorJoseph Edward Hornyak MD, PhD
Department of Physical Medicine & Rehabilitation, University of Michigan, Ann Arbor, Michigan, USA
Search for more papers by this authorFatma Gul MD, MS
Department of Physical Medicine and Rehabilitation Department, University of Texas, Southwestern Medical Center, Dallas, Texas, USA
Search for more papers by this authorSupreet Deshpande MD
Department of Pediatric Rehabilitation Medicine, Gillette Children's Hospital, St.Paul, Minnesota, USA
Department of Rehabilitation Medicine, University of Minnesota, Minneapolis, Minnesota, USA
Search for more papers by this authorSusan Biffl MD
Division Pediatric Rehabilitation Medicine Department of Orthopedic Surgery, UCSD Rady Children's Hospital, San Diego, California, USA
Search for more papers by this authorZainab Al Lawati MD, MEd, FRCPC, FAAPMR
Department of Rehabilitation Medicine, University of Minnesota, Minneapolis, Minnesota, USA
Search for more papers by this authorAbraham Alfaro PhD, DO
Rehabilitation Medicine, AtlantiCare Health Services, Inc., Federally Qualified Health Center (FQHC), Atlantic City, New Jersey, USA
Search for more papers by this authorAbstract
Background
The American Academy of Physical Medicine and Rehabilitation (AAPM&R) conducted a comprehensive review in 2021 to identify opportunities for enhancing the care of adult and pediatric patients with spasticity. A technical expert panel (TEP) was convened to develop consensus-based practice recommendations aimed at addressing gaps in spasticity care.
Objective
To develop consensus-based practice recommendations to identify and address gaps in spasticity care.
Methods
The Spasticity TEP engaged in a 16-month virtual meeting process, focusing on formulating search terms, refining research questions, and conducting a structured evidence review. Evidence quality was assessed by the AAPM&R Evidence, Quality and Performance Committee (EQPC), and a modified Delphi process was employed to achieve consensus on recommendation statements and evidence grading. The Strength of Recommendation Taxonomy (SORT) guided the rating of individual studies and the strength of recommendations.
Results
The TEP approved five recommendations for spasticity management and five best practices for assessment and management, with one recommendation unable to be graded due to evidence limitations. Best practices were defined as widely accepted components of care, while recommendations required structured evidence reviews and grading. The consensus guidance statement represents current best practices and evidence-based treatment options, intended for use by PM&R physicians caring for patients with spasticity.
Conclusion
This consensus guidance provides clinicians with practical recommendations for spasticity assessment and management based on the best available evidence and expert opinion. Clinical judgment should be exercised, and recommendations tailored to individual patient needs, preferences, and risk profiles. The accompanying table summarizes the best practice recommendations for spasticity assessment and management, reflecting principles with little controversy in care delivery.
REFERENCES
- 1Chang E, Ghosh N, Yanni D, Lee S, Alexandru D, Mozaffar T. A review of spasticity treatments: pharmacological and interventional approaches. Crit Rev Phys Rehabil Med. 2013; 25(1–2): 11-22. doi:10.1615/CritRevPhysRehabilMed.2013007945
- 2Gormley ME Jr, Krach LE, Piccini L. Spasticity management in the child with spastic quadriplegia. Eur J Neurol. 2001; 8(Suppl 5): 127-135. doi:10.1046/j.1468-1331.2001.00045.x
- 3Raghavan P. Neural basis of spasticity. In: P Raghavan, ed. Spasticity and Muscle Stiffness: Restoring Form and Function. 1st ed. Springer Nature; 2022.
10.1007/978-3-030-96900-4_1 Google Scholar
- 4Lance JW. Symposium synopsis. In: RG Feldman, RR Young, WP Koella, eds. Spasticity: Disordered Motor Control. Year Book Medical Publishers; 1980.
- 5Pandyan AD, Gregoric M, Barnes MP, et al. Spasticity: clinical perceptions, neurological realities and meaningful measurement. Disabil Rehabil. 2005; 27(1–2): 2-6. doi:10.1080/09638280400014576
- 6Li S, Francisco GE, Rymer WZ. A new definition of poststroke spasticity and the interference of spasticity with motor recovery from acute to chronic stages. Neurorehabil Neural Repair. 2021; 35(7): 601-610. doi:10.1177/15459683211011214
- 7Mayer NH, Herman RM. Phenomenology of muscle overactivity in the upper motor neuron syndrome. Eura Medicophys. 2004; 40(2): 85-110.
- 8Raghavan P, Stecco A, Menon R, Cowman MK, Regatte R. Mechanisms of development of passive mechanical muscle stiffness. In: P Raghavan, ed. Spasticity and Muscle Stiffness: Restoring Form and Function. 1st ed. Springer Nature; 2022.
10.1007/978-3-030-96900-4_6 Google Scholar
- 9Ebell MH, Siwek J, Weiss BD, et al. Strength of recommendation taxonomy (SORT): a patient-centered approach to grading evidence in the medical literature. J Am Board Fam Pract. 2004; 17(1): 59-67. doi:10.3122/jabfm.17.1.59
- 10Park TS, Uhm SY, Walter DM, Meyer NL, Dobbs MB. Functional outcome of adulthood selective dorsal rhizotomy for spastic diplegia. Cureus. 2019; 11(7):e5184. doi:10.7759/cureus.5184
- 11Odonkor CA, Esparza R, Flores LE, et al. Disparities in health care for black patients in physical medicine and rehabilitation in the United States: a narrative review. PM R. 2021; 13(2): 180-203. doi:10.1002/pmrj.12509
- 12Flores LE, Verduzco-Gutierrez M, Molinares D, Silver JK. Disparities in health care for hispanic patients in physical medicine and rehabilitation in the United States: a narrative review. Am J Phys Med Rehabil. 2020; 99(4): 338-347. doi:10.1097/PHM.0000000000001342
- 13Saadi A, Himmelstein DU, Woolhandler S, Mejia NI. Racial disparities in neurologic health care access and utilization in the United States. Neurology. 2017; 88(24): 2268-2275. doi:10.1212/WNL.0000000000004025
- 14Houtrow A, Martin AJ, Harris D, et al. Health equity for children and youth with special health care needs: a vision for the future. Pediatrics. 2022; 149(Suppl 7):e2021056150F. doi:10.1542/peds.2021-056150F
- 15Kazerooni R, Healy S, Verduzco-Gutierrez M. Disparities in access to spasticity chemodenervation specialists in the US: a retrospective cross-sectional study. Am J Phys Med Rehabil. 2023; 22: 203-207. doi:10.1097/PHM.0000000000002375
10.1097/PHM.0000000000002375 Google Scholar
- 16Esquenazi A, Bloudek L, Migliaccio-Walle K, et al. Healthcare resource utilization and costs among patients with post-stroke spasticity before and after spasticity management including onabotulinumtoxina. J Rehabil Med. 2023; 55:jrm11626. doi:10.2340/jrm.v55.11626
- 17de Havenon A, Sheth K, Johnston KC, et al. Acute ischemic stroke interventions in the United States and racial, socioeconomic, and geographic disparities. Neurology. 2021; 97(23): e2292-e2303. doi:10.1212/WNL.0000000000012943
- 18Bai YL, Hu YS, Wu Y, et al. Long-term three-stage rehabilitation intervention alleviates spasticity of the elbows, fingers, and plantar flexors and improves activities of daily living in ischemic stroke patients: a randomized, controlled trial. Neuroreport. 2014; 25(13): 998-1005. doi:10.1097/WNR.0000000000000194
- 19Larkin T, Martinez V, Scully T, Martinez D, Hayes C, Verduzco-Gutierrez M. Upper extremity spasticity: the quality of online patient resources. Am J Phys med Rehabil. 2023; 24: 18-23. doi:10.1097/PHM.0000000000002297
10.1097/PHM.0000000000002297 Google Scholar
- 20Verduzco-Gutierrez M, Romanoski NL, Capizzi AN, et al. Spasticity outpatient evaluation via telemedicine: a practical framework. Am J Phys Med Rehabil. 2020; 99(12): 1086-1091. doi:10.1097/PHM.0000000000001594
- 21Kim J, Sin M, Kim WS, et al. Remote assessment of post-stroke elbow function using internet-based telerobotics: a proof-of-concept study. Front Neurol. 2020; 11:583101. doi:10.3389/fneur.2020.583101
- 22Tenforde AS, Alexander JJ, Alexander M, et al. Telehealth in PM&R: past, present, and future in clinical practice and opportunities for translational research. PM R. 2023; 15(9): 1156-1174. doi:10.1002/pmrj.13029
- 23Norman J, Stowers J, Verduzco-Gutierrez M. Parking meters to touch screens: the unforeseen barriers that expansion of telemedicine presents to the disability community. Am J Phys Med Rehabil. 2021; 100(11): 1105-1108. doi:10.1097/PHM.0000000000001771
- 24Verduzco-Gutierrez M, Lara AM, Annaswamy TM. When disparities and disabilities collide: inequities during the COVID-19 pandemic. PM R. 2021; 13(4): 412-414. doi:10.1002/pmrj.12551
- 25Annaswamy TM, Verduzco-Gutierrez M, Frieden L. Telemedicine barriers and challenges for persons with disabilities: COVID-19 and beyond. Disabil Health J. 2020; 13(4):100973. doi:10.1016/j.dhjo.2020.100973
- 26Walshe FM. Contributions of John Hughlings Jackson to neurology. A brief introduction to his teachings. Arch Neurol. 1961; 5: 119-131. doi:10.1001/archneur.1961.00450140001001
- 27Gracies JM, Bayle N, Vinti M, et al. Five-step clinical assessment in spastic paresis. Eur J Phys Rehabil Med. 2010; 46(3): 411-421.
- 28Turner-Stokes L, Ashford S, Esquenazi A, et al. A comprehensive person-centered approach to adult spastic paresis: a consensus-based framework. Eur J Phys Rehabil Med. 2018; 54(4): 605-617. doi:10.23736/S1973-9087.17.04808-0
- 29Ashford S, Turner-Stokes L. Goal attainment for spasticity management using botulinum toxin. Physiother Res Int. 2006; 11(1): 24-34. doi:10.1002/pri.36
- 30Baude M, Ghedira M, Pradines M, Gracies J-M. Clinical assessment of the syndrome of spastic paresis. In: P Raghavan, ed. Spasticity and Muscle Stiffness: Restoring Form and Function. 1st ed. Springer Nature; 2022.
10.1007/978-3-030-96900-4_3 Google Scholar
- 31Gracies JM. Coefficients of impairment in deforming spastic paresis. Ann Phys Rehabil med. 2015; 58(3): 173-178. doi:10.1016/j.rehab.2015.04.004
- 32Lam WWT, Tang YM, Fong KNK. A systematic review of the applications of markerless motion capture (MMC) technology for clinical measurement in rehabilitation. J Neuroeng Rehabil. 2023; 20(1): 57. doi:10.1186/s12984-023-01186-9
- 33Scott B, Seyres M, Philp F, Chadwick EK, Blana D. Healthcare applications of single camera markerless motion capture: a scoping review. PeerJ. 2022; 10:e13517. doi:10.7717/peerj.13517
- 34Bui HT, Gagnon C, Audet O, Mathieu J, Leone M. Measurement properties of a new wireless electrogoniometer for quantifying spasticity during the pendulum test in ARSACS patients. J Neurol Sci. 2017; 375: 181-185. doi:10.1016/j.jns.2017.01.065
- 35Germanotta M, Taborri J, Rossi S, et al. Spasticity measurement based on tonic stretch reflex threshold in children with cerebral palsy using the PediAnklebot. Front Hum Neurosci. 2017; 11: 277. doi:10.3389/fnhum.2017.00277
- 36Li X, Shin H, Li S, Zhou P. Assessing muscle spasticity with myotonometric and passive stretch measurements: validity of the Myotonometer. Sci Rep. 2017; 7: 44022. doi:10.1038/srep44022
- 37Plantin J, Pennati GV, Roca P, et al. Quantitative assessment of hand spasticity after stroke: imaging correlates and impact on motor recovery. Front Neurol. 2019; 10: 836. doi:10.3389/fneur.2019.00836
- 38Pennati GV, Plantin J, Borg J, Lindberg PG. Normative NeuroFlexor data for detection of spasticity after stroke: a cross-sectional study. J Neuroeng Rehabil. 2016; 13: 30. doi:10.1186/s12984-016-0133-x
- 39Wang R, Herman P, Ekeberg Ö, Gäverth J, Fagergren A, Forssberg H. Neural and non-neural related properties in the spastic wrist flexors: an optimization study. Med Eng Phys. 2017; 47: 198-209. doi:10.1016/j.medengphy.2017.06.023
- 40Wu YN, Park HS, Chen JJ, Ren Y, Roth EJ, Zhang LQ. Position as well as velocity dependence of spasticity-four-dimensional characterizations of catch angle. Front Neurol. 2018; 9: 863. doi:10.3389/fneur.2018.00863
- 41Rasmussen HM, Pedersen NW, Overgaard S, et al. Gait analysis for individually tailored interdisciplinary interventions in children with cerebral palsy: a randomized controlled trial. Dev Med Child Neurol. 2019; 61(10): 1189-1195. doi:10.1111/dmcn.14178
- 42Flanagan SR, Cynthia H, Petrucelli R, Ragucci M. Medical exacerbation of spasticity. In: P Raghavan, ed. Spasticity and Muscle Stiffness: Restoring Form and Function. 1st ed. Springer Nature; 2022.
10.1007/978-3-030-96900-4_9 Google Scholar
- 43Raghavan P. Framework for the treatment of spasticity and muscle stiffness. In: P Raghavan, ed. Spasticity and Muscle Stiffness: Restoring Form and Function. 1st ed. Springer Nature; 2022.
10.1007/978-3-030-96900-4_8 Google Scholar
- 44Francisco GE, Li S. Spasticity. In: DX Cifu, ed. Physical Medicine and Rehabilitation. 5th ed. Elsevier; 2016: 487-489.
- 45Pierson SH. Outcome measures in spasticity management. Muscle Nerve Suppl. 1997; 6: S36-S60.
- 46Khan F, Amatya B, Bensmail D, Yelnik A. Non-pharmacological interventions for spasticity in adults: an overview of systematic reviews. Ann Phys Rehabil Med. 2019; 62(4): 265-273. doi:10.1016/j.rehab.2017.10.001
- 47Novak I, Morgan C, Fahey M, et al. State of the evidence traffic lights 2019: systematic review of interventions for preventing and treating children with cerebral palsy. Curr Neurol Neurosci Rep. 2020; 20(2): 3. doi:10.1007/s11910-020-1022-z
- 48Gormley ME Jr. Treatment of neuromuscular and musculoskeletal problems in cerebral palsy. Pediatr Rehabil. 2001; 4(1): 5-16. doi:10.1080/13638490151068393
- 49Katz RT. Management of spasticity. Am J Phys Med Rehabil. 1988; 67(3): 108-116. doi:10.1097/00002060-198806000-00004
- 50Kita M, Goodkin DE. Drugs used to treat spasticity. Drugs. 2000; 59(3): 487-495. doi:10.2165/00003495-200059030-00006
- 51Basmajian JV, Shankardass K, Russell D, Yucel V. Ketazolam treatment for spasticity: double-blind study of a new drug. Arch Phys Med Rehabil. 1984; 65(11): 698-701.
- 52Rode G, Maupas E, Luaute J, Courtois-Jacquin S, Boisson D. Traitements médicamenteux de la spasticité [medical treatment of spasticity]. Neurochirurgie. 2003; 49(2–3 Pt 2): 247-255.
- 53Reilly M, Liuzzo K, Blackmer AB. Pharmacological management of spasticity in children with cerebral palsy. J Pediatr Health Care. 2020; 34(5): 495-509. doi:10.1016/j.pedhc.2020.04.010
- 54Romito JW, Turner ER, Rosener JA, et al. Baclofen therapeutics, toxicity, and withdrawal: a narrative review. SAGE Open Med. 2021; 9:20503121211022197. doi:10.1177/20503121211022197
- 55Meythaler JM, Kowalski S. Pharmacologic management of spasticity: oral medications. In: A Brashear, EP Elovic, eds. Spasticity: Diagnosis and Management. 1st ed. Demos Medical Publishing; 2011: 199-227.
- 56Schulz E, Mathew OP. Is oral baclofen effective in neonatal hypertonia? J Child Neurol. 2012; 27(2): 197-199. doi:10.1177/0883073811416238
- 57Deon LL, Gaebler-Spira D. Assessment and treatment of movement disorders in children with cerebral palsy. Orthop Clin North Am. 2010; 41(4): 507-517. doi:10.1016/j.ocl.2010.06.001
- 58Verrier M, Ashby P, MacLeod S. Effect of diazepam on muscle contraction in spasticity. Am J Phys Med. 1976; 55(4): 184-191.
- 59Wilson LA, McKechnie AA. Oral diazepam in the treatment of spasticity in paraplegia a double-blind trial and subsequent impressions. Scott Med J. 1966; 11(2): 46-51. doi:10.1177/003693306601100202
- 60Abbruzzese G. The medical management of spasticity. Eur J Neurol. 2002; 9(Suppl 1): 30-61. doi:10.1046/j.1468-1331.2002.0090s1030.x
- 61Sellers EM, Busto U. Diazepam withdrawal syndrome. Can Med Assoc J. 1983; 129(2): 97-100.
- 62Leung FW, Guze PA. Diazepam withdrawal. West J Med. 1983; 138(1): 98-101.
- 63Robinson GM, Sellers EM. Diazepam withdrawal seizures. Can Med Assoc J. 1982; 126(8): 944-945.
- 64Palazón García R, Benavente Valdepeñas A, Arroyo RO. Protocolo de uso de la tizanidina en la parálisis cerebral infantil [Protocol for tizanidine use in infantile cerebral palsy]. An Pediatr (Barc). 2008; 68(5): 511-515. doi:10.1157/13120053
- 65Kamen L, Henney HR 3rd, Runyan JD. A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. Curr Med Res Opin. 2008; 24(2): 425-439. doi:10.1185/030079908x261113
- 66Członkowski A, Mirowska D. Pharmacotherapy for spasticity. Ortop Traumatol Rehabil. 2002; 4(1): 54-56.
- 67Ono H, Matsumoto K, Kato K, et al. Effects of tizanidine, a centrally acting muscle relaxant, on motor systems. Gen Pharmacol. 1986; 17(2): 137-142. doi:10.1016/0306-3623(86)90130-8
- 68Ghanavatian S, Derian A. Tizanidine. In: StatPearls, ed. Treasure Island. StatPearls Publishing; 2023.
- 69Malanga G, Reiter RD, Garay E. Update on tizanidine for muscle spasticity and emerging indications. Expert Opin Pharmacother. 2008; 9(12): 2209-2215. doi:10.1517/14656566.9.12.2209
- 70Landau WM. Tizanidine and spasticity. Neurology. 1995; 45(12): 2295-2296. doi:10.1212/wnl.45.12.2295
- 71Vásquez-Briceño A, Arellano-Saldaña ME, León-Hernández SR, Morales-Osorio MG. Utilidad de la tizanidina. Seguimiento de un ano en el tratamiento de la espasticidad en la paralisis cerebral infantil [The usefulness of tizanidine. A one-year follow-up of the treatment of spasticity in infantile cerebral palsy]. Rev Neurol. 2006; 43(3): 132-136.
- 72Tilton A, Vargus-Adams J, Delgado MR. Pharmacologic treatment of spasticity in children. Semin Pediatr Neurol. 2010; 17(4): 261-267. doi:10.1016/j.spen.2010.10.009
- 73Pinder RM, Brogden RN, Speight TM, Avery GS. Dantrolene sodium: a review of its pharmacological properties and therapeutic efficacy in spasticity. Drugs. 1977; 13(1): 3-23. doi:10.2165/00003495-197713010-00002
- 74Saulino M, Jacobs BW. The pharmacological management of spasticity. J Neurosci Nurs. 2006; 38(6): 456-459.
- 75 Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society, Delgado MR, Hirtz D, et al. Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 2010; 74(4): 336-343. doi:10.1212/WNL.0b013e3181cbcd2f
- 76Ertzgaard P, Campo C, Calabrese A. Efficacy and safety of oral baclofen in the management of spasticity: a rationale for intrathecal baclofen. J Rehabil med. 2017; 49(3): 193-203. doi:10.2340/16501977-2211
- 77Moran LR, Cincotta T, Krishnamoorthy K, Insoft RM. The use of baclofen in full-term neonates with hypertonia. J Perinatol. 2005; 25(1): 66-68. doi:10.1038/sj.jp.7211194
- 78Campistol J. Farmacos empleados por via oral para el tratamiento de la espasticidad [orally administered drugs in the treatment of spasticity]. Rev Neurol. 2003; 37(1): 70-74.
- 79Fehlings D, Brown L, Harvey A, et al. Pharmacological and neurosurgical interventions for managing dystonia in cerebral palsy: a systematic review. Dev Med Child Neurol. 2018; 60(4): 356-366. doi:10.1111/dmcn.13652
- 80Gracies JM, Nance P, Elovic E, McGuire J, Simpson DM. Traditional pharmacological treatments for spasticity. Part II: general and regional treatments. Muscle Nerve Suppl. 1997; 6: S92-S120.
- 81Lapeyre E, Kuks JB, Meijler WJ. Spasticity: revisiting the role and the individual value of several pharmacological treatments. NeuroRehabilitation. 2010; 27(2): 193-200. doi:10.3233/NRE-2010-0596
- 82Peck J, Urits I, Crane J, et al. Oral muscle relaxants for the treatment of chronic pain associated with cerebral palsy. Psychopharmacol Bull. 2020; 50(4 Suppl 1): 142-162.
- 83Harvison PJ. Dalteparin. In: SJ Enna, DB Bylund, eds. xPharm: The Comprehensive Pharmacology Reference. Elsevier; 2007.
10.1016/B978-008055232-3.61540-5 Google Scholar
- 84Martinez-Paz C, García-Cabrera E, Vilches-Arenas Á. Effectiveness and safety of cannabinoids as an add-on therapy in the treatment of resistant spasticity in multiple sclerosis: a systematic review. Cannabis Cannabinoid Res. 2023; 8(4): 580-588. doi:10.1089/can.2022.0254
- 85Yadav V, Bever C Jr, Bowen J, et al. Summary of evidence-based guideline: complementary and alternative medicine in multiple sclerosis: report of the guideline development subcommittee of the American Academy of Neurology. Neurology. 2014; 82(12): 1083-1092. doi:10.1212/WNL.0000000000000250
- 86Whiting PF, Wolff RF, Deshpande S, et al. Cannabinoids for medical use: a systematic review and meta-analysis [published correction appears in JAMA. 2015;314(5):520] [published correction appears in JAMA. 2015;314(8):837] [published correction appears in JAMA. 2015;314(21):2308] [published correction appears in JAMA. 2016;315(14):1522]. JAMA. 2015; 313(24): 2456-2473. doi:10.1001/jama.2015.6358
- 87Francisco GE, McGuire JR. Poststroke spasticity management. Stroke. 2012; 43(11): 3132-3136. doi:10.1161/STROKEAHA.111.639831
- 88Ploypetch T, Kwon JY, Armstrong HF, Kim H. A retrospective review of unintended effects after single-event multi-level Chemoneurolysis with botulinum toxin-a and phenol in children with cerebral palsy. PM R. 2015; 7(10): 1073-1080. doi:10.1016/j.pmrj.2015.05.020
- 89Furr-Stimming E, Boyle AM, Schiess MC. Spasticity and intrathecal baclofen. Semin Neurol. 2014; 34(5): 591-596. doi:10.1055/s-0034-1396012
- 90Awaad Y, Rizk T, Siddiqui I, Roosen N, McIntosh K, Waines GM. Complications of intrathecal baclofen pump: prevention and cure. ISRN Neurol. 2012; 2012:575168. doi:10.5402/2012/575168
- 91Karri J, Mas MF, Francisco GE, Li S. Practice patterns for spasticity management with phenol neurolysis. J Rehabil Med. 2017; 49(6): 482-488. doi:10.2340/16501977-2239
- 92Farag SM, Mohammed MO, El-Sobky TA, ElKadery NA, ElZohiery AK. Botulinum toxin a injection in treatment of upper limb spasticity in children with cerebral palsy: a systematic review of randomized controlled trials. JBJS Rev. 2020; 8(3):e0119. doi:10.2106/JBJS.RVW.19.00119
- 93Simpson DM, Hallett M, Ashman EJ, et al. Practice guideline update summary: botulinum neurotoxin for the treatment of blepharospasm, cervical dystonia, adult spasticity, and headache: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2016; 86(19): 1818-1826. doi:10.1212/WNL.0000000000002560
- 94Andringa A, van de Port I, van Wegen E, Ket J, Meskers C, Kwakkel G. Effectiveness of botulinum toxin treatment for upper limb spasticity poststroke over different ICF domains: a systematic review and meta-analysis. Arch Phys Med Rehabil. 2019; 100(9): 1703-1725. doi:10.1016/j.apmr.2019.01.016
- 95Dong Y, Wu T, Hu X, Wang T. Efficacy and safety of botulinum toxin type A for upper limb spasticity after stroke or traumatic brain injury: a systematic review with meta-analysis and trial sequential analysis. Eur J Phys Rehabil Med. 2017; 53(2): 256-267. doi:10.23736/S1973-9087.16.04329-X
- 96Jia S, Liu Y, Shen L, Liang X, Xu X, Wei Y. Botulinum toxin type a for upper limb spasticity in poststroke patients: a meta-analysis of randomized controlled trials. J Stroke Cerebrovasc Dis. 2020; 29(6):104682. doi:10.1016/j.jstrokecerebrovasdis.2020.104682
- 97Sun LC, Chen R, Fu C, et al. Efficacy and safety of botulinum toxin type A for limb spasticity after stroke: a meta-analysis of randomized controlled trials. Biomed Res Int. 2019; 2019:8329306. doi:10.1155/2019/8329306
- 98Cofré Lizama LE, Khan F, Galea MP. Beyond speed: gait changes after botulinum toxin injections in chronic stroke survivors (a systematic review). Gait Posture. 2019; 70: 389-396. doi:10.1016/j.gaitpost.2019.03.035
- 99Varvarousis DN, Martzivanou C, Dimopoulos D, Dimakopoulos G, Vasileiadis GI, Ploumis A. The effectiveness of botulinum toxin on spasticity and gait of hemiplegic patients after stroke: a systematic review and meta-analysis. Toxicon. 2021; 203: 74-84. doi:10.1016/j.toxicon.2021.09.020
- 100Esquenazi A, Bavikatte G, Bandari DS, et al. Long-term observational results from the ASPIRE study: OnabotulinumtoxinA treatment for adult lower limb spasticity. PM R. 2021; 13(10): 1079-1093. doi:10.1002/pmrj.12517
- 101Alfaro A, Tsai T. Phenol injections to musculocutaneous nerves: decrease in spasticity for elbow flexion, and complications. Muscle Nerve. 2016; 54(3): 569.
- 102Keenan MA, Tomas ES, Stone L, Gerstén LM. Percutaneous phenol block of the musculocutaneous nerve to control elbow flexor spasticity. J Hand Surg Am. 1990; 15(2): 340-346. doi:10.1016/0363-5023(90)90120-g
- 103Matsumoto ME, Berry J, Yung H, Matsumoto M, Munin MC. Comparing electrical stimulation with and without ultrasound guidance for phenol neurolysis to the musculocutaneous nerve. PM R. 2018; 10(4): 357-364. doi:10.1016/j.pmrj.2017.09.006
- 104Zhang B, Darji N, Francisco GE, Li S. The time course of onset and peak effects of phenol neurolysis. Am J Phys Med Rehabil. 2021; 100(3): 266-270. doi:10.1097/PHM.0000000000001563
- 105Kong KH, Chua KS. Neurolysis of the musculocutaneous nerve with alcohol to treat poststroke elbow flexor spasticity. Arch Phys Med Rehabil. 1999; 80(10): 1234-1236. doi:10.1016/s0003-9993(99)90021-7
- 106Lee DG, Jang SH. Ultrasound guided alcohol neurolysis of musculocutaneous nerve to relieve elbow spasticity in hemiparetic stroke patients. NeuroRehabilitation. 2012; 31(4): 373-377. doi:10.3233/NRE-2012-00806
- 107Lee J, Lee YS. Percutaneous chemical nerve block with ultrasound-guided intraneural injection. Eur Radiol. 2008; 18(7): 1506-1512. doi:10.1007/s00330-008-0909-x
- 108Akkaya T, Unlu E, Alptekin A, Gumus HI, Umay E, Cakci A. Neurolytic phenol blockade of the obturator nerve for severe adductor spasticity. Acta Anaesthesiol Scand. 2010; 54(1): 79-85. doi:10.1111/j.1399-6576.2009.02130.x
- 109Alfaro A, Flancia F. Phenol injections to obturator nerves: decrease in spasticity, and complications. Poster 90. 2015; 9S(7): S120-S121. doi:10.1016/j.pmrj.2015.06.129
10.1016/j.pmrj.2015.06.129 Google Scholar
- 110Alsuhabani A, Ethans K, Casey A, Skrabek R, Chateau D, Sutherland E. Ultrasound guided phenol block of the obturator nerve for severe adductor spasticity: a pilot study. Int J Neurorehabilitation. 2016; 3(2): 1-5.
10.4172/2376-0281.1000202 Google Scholar
- 111Ghai A, Sangwan SS, Hooda S, Garg N, Kundu ZS, Gupta T. Evaluation of interadductor approach in neurolytic blockade of obturator nerve in spastic patients. Saudi J Anaesth. 2013; 7(4): 420-426. doi:10.4103/1658-354X.121074
- 112Lam K, Wong D, Tam CK, et al. Ultrasound and electrical stimulator-guided obturator nerve block with phenol in the treatment of hip adductor spasticity in long-term care patients: a randomized, triple blind, placebo controlled study. J Am Med Dir Assoc. 2015; 16(3): 238-246. doi:10.1016/j.jamda.2014.10.005
- 113Ofluoglu D, Esquenazi A, Hirai B. Temporospatial parameters of gait after obturator neurolysis in patients with spasticity. Am J Phys Med Rehabil. 2003; 82(11): 832-836. doi:10.1097/01.PHM.0000091986.32078.CD
- 114Park ES, Rha DW, Lee WC, Sim EG. The effect of obturator nerve block on hip lateralization in low functioning children with spastic cerebral palsy. Yonsei Med J. 2014; 55(1): 191-196. doi:10.3349/ymj.2014.55.1.191
- 115Razaq S, Fahim A, Arshad AM. Obturator nerve block with aqueous phenol reduces hip adductor spasticity – a single centre experience. Pakistan J Neurol Surg. 2020; 15(4): 30-35.
- 116Selmi NH, Şahin S, Gurbet A, et al. Obturator nerve block in adductor spasticity: comparison of peripheral nerve stimulator and ultrasonography. Turk J Anaesth Reanim. 2013; 41: 121-125. doi:10.5152/TJAR.2013.49
10.5152/TJAR.2013.49 Google Scholar
- 117Viel EJ, Perennou D, Ripart J, Pélissier J, Eledjam JJ. Neurolytic blockade of the obturator nerve for intractable spasticity of adductor thigh muscles. Eur J Pain. 2002; 6(2): 97-104. doi:10.1053/eujp.2001.0269
- 118Wassef MR. Interadductor approach to obturator nerve blockade for spastic conditions of adductor thigh muscles. Reg Anesth. 1993; 18(1): 13-17.
- 119Yaşar E, Tok F, Taşkaynatan MA, Yilmaz B, Balaban B, Alaca R. The effects of phenol neurolysis of the obturator nerve on the distribution of buttock-seat interface pressure in spinal cord injury patients with hip adductor spasticity. Spinal Cord. 2010; 48(11): 828-831. doi:10.1038/sc.2010.34
- 120Alfaro A. Tibial nerve injections with phenol decreased spasticity and improved ankle dorsiflexion. Poster at the American Academy of Physical Medicine and Rehabilitation annual meeting. Baltimore, MD. 2022,S1(14).
- 121Kocabas H, Salli A, Demir AH, Ozerbil OM. Comparison of phenol and alcohol neurolysis of tibial nerve motor branches to the gastrocnemius muscle for treatment of spastic foot after stroke: a randomized controlled pilot study. Eur J Phys Rehabil Med. 2010; 46(1): 5-10.
- 122Khalili AA, Betts HB. Peripheral nerve block with phenol in the management of spasticity. Indications and complications. JAMA. 1967; 200(13): 1155-1157.
- 123Khalili AA, Harmel MH, Forster S, Benton JG. Management of spasticity by selective peripheral nerve block with dilute phenol solutions in clinical rehabilitation. Arch Phys Med Rehabil. 1964; 45: 513-519.
- 124Kirazli Y, On AY, Kismali B, Aksit R. Comparison of phenol block and botulinus toxin type A in the treatment of spastic foot after stroke: a randomized, double-blind trial. Am J Phys Med Rehabil. 1998; 77(6): 510-515. doi:10.1097/00002060-199811000-00012
- 125Manca M, Merlo A, Ferraresi G, Cavazza S, Marchi P. Botulinum toxin type A versus phenol. A clinical and neurophysiological study in the treatment of ankle clonus. Eur J Phys Rehabil Med. 2010; 46(1): 11-18.
- 126On AY, Kirazli Y, Kismali B, Aksit R. Mechanisms of action of phenol block and botulinus toxin type A in relieving spasticity: electrophysiologic investigation and follow-up. Am J Phys med Rehabil. 1999; 78(4): 344-349. doi:10.1097/00002060-199907000-00010
- 127Petrillo CR, Chu DS, Davis SW. Phenol block of the tibial nerve in the hemiplegic patient. Orthopedics. 1980; 3(9): 871-874. doi:10.3928/0147-7447-19800901-10
- 128Petrillo CR, Knoploch S. Phenol block of the tibial nerve for spasticity: a long-term follow-up study. Int Disabil Stud. 1988; 10(3): 97-100. doi:10.3109/09638288809164120
- 129Chua KS, Kong KH. Clinical and functional outcome after alcohol neurolysis of the tibial nerve for ankle-foot spasticity. Brain Inj. 2001; 15(8): 733-739. doi:10.1080/02699050010009775
- 130Jang SH, Ahn SH, Park SM, Kim SH, Lee KH, Lee ZI. Alcohol neurolysis of tibial nerve motor branches to the gastrocnemius muscle to treat ankle spasticity in patients with hemiplegic stroke. Arch Phys Med Rehabil. 2004; 85(3): 506-508. doi:10.1016/s0003-9993(03)00468-4
- 131Demir Y, Şan AU, Kesikburun S, Yaşar E, Yılmaz B. The short-term effect of ultrasound and peripheral nerve stimulator-guided femoral nerve block with phenol on the outcomes of patients with traumatic spinal cord injury. Spinal Cord. 2018; 56(9): 907-912. doi:10.1038/s41393-018-0142-7
- 132Kong KH, Chua KS. Outcome of obturator nerve block with alcohol for the treatment of hip adductor spasticity. Int J Rehabil Res. 1999; 22(4): 327-329. doi:10.1097/00004356-199912000-00011
- 133Hecht JS. Subscapular nerve block in the painful hemiplegic shoulder. Arch Phys Med Rehabil. 1992; 73(11): 1036-1039.
- 134Vadivelu S, Stratton A, Pierce W. Pediatric tone management. Phys Med Rehabil Clin N Am. 2015; 26(1): 69-78. doi:10.1016/j.pmr.2014.09.008
- 135Evans SH, Cameron MW, Burton JM. Hypertonia. Curr Probl Pediatr Adolesc Health Care. 2017; 47(7): 161-166. doi:10.1016/j.cppeds.2017.06.005
- 136Nahm NJ, Graham HK, Gormley ME Jr, Georgiadis AG. Management of hypertonia in cerebral palsy. Curr Opin Pediatr. 2018; 30(1): 57-64. doi:10.1097/MOP.0000000000000567
- 137Wong AM, Chen CL, Chen CP, Chou SW, Chung CY, Chen MJ. Clinical effects of botulinum toxin A and phenol block on gait in children with cerebral palsy. Am J Phys Med Rehabil. 2004; 83(4): 284-291. doi:10.1097/01.phm.0000118038.02326.ca
- 138Gooch JL, Patton CP. Combining botulinum toxin and phenol to manage spasticity in children. Arch Phys Med Rehabil. 2004; 85(7): 1121-1124. doi:10.1016/j.apmr.2003.09.032
- 139Easton JK, Ozel T, Halpern D. Intramuscular neurolysis for spasticity in children. Arch Phys Med Rehabil. 1979; 60(4): 155-158.
- 140Spira R. Management of spasticity in cerebral palsied children by peripheral nerve block with phenol. Dev Med Child Neurol. 1971; 13(2): 164-173. doi:10.1111/j.1469-8749.1971.tb03241.x
- 141Yadav SL, Singh U, Dureja GP, Singh KK, Chaturvedi S. Phenol block in the management of spastic cerebral palsy. Indian J Pediatr. 1994; 61(3): 249-255. doi:10.1007/BF02752218
- 142Morrison JE Jr, Matthews D, Washington R, Fennessey PV, Harrison LM. Phenol motor point blocks in children: plasma concentrations and cardiac dysrhythmias. Anesthesiology. 1991; 75(2): 359-362. doi:10.1097/00000542-199108000-00027
- 143Meythaler JM. Use of intrathecal baclofen in brain injury patients. Arch Phys Med Rehabil. 1994; 75(9): 1036. doi:10.1016/0003-9993(94)90755-2
10.1016/0003-9993(94)90755-2 Google Scholar
- 144Meythaler JM, McCary A, Hadley MN. Prospective assessment of continuous intrathecal infusion of baclofen for spasticity caused by acquired brain injury: a preliminary report. J Neurosurg. 1997; 87(3): 415-419. doi:10.3171/jns.1997.87.3.0415
- 145Meythaler JM, Guin-Renfroe S, Hadley MN. 11. Continuously infused intrathecal baclofen (Itb) for spastic-hypertonia in adult cerebral palsy. Am J Phys Med Rehabil. 1998; 77(2): 173. doi:10.1097/00002060-199803000-00037
10.1097/00002060?199803000?00037 Google Scholar
- 146Meythaler JM, Guin-Renfroe S, Hadley MN. Continuously infused intrathecal baclofen for spastic/dystonic hemiplegia: a preliminary report. Am J Phys Med Rehabil. 1999; 78(3): 247-254. doi:10.1097/00002060-199905000-00012
- 147Meythaler JM, Guin-Renfroe S, Brunner RC, Hadley MN. Intrathecal baclofen for spastic hypertonia from stroke. Stroke. 2001; 32(9): 2099-2109. doi:10.1161/hs0901.095682
- 148Meythaler JM, Guin-Renfroe S, Law C, Grabb P, Hadley MN. Continuously infused intrathecal baclofen over 12 months for spastic hypertonia in adolescents and adults with cerebral palsy. Arch Phys Med Rehabil. 2001; 82(2): 155-161. doi:10.1053/apmr.2001.19246
- 149Meythaler JM, Steers WD, Tuel SM, Cross LL, Haworth CS. Continuous intrathecal baclofen in spinal cord spasticity. A prospective study. Am J Phys Med Rehabil. 1992; 71(6): 321-327. doi:10.1097/00002060-199212000-00003
- 150Coffey JR, Cahill D, Steers W, et al. Intrathecal baclofen for intractable spasticity of spinal origin: results of a long-term multicenter study. J Neurosurg. 1993; 78(2): 226-232. doi:10.3171/jns.1993.78.2.0226
- 151Albright AL, Gilmartin R, Swift D, Krach LE, Ivanhoe CB, McLaughlin JF. Long-term intrathecal baclofen therapy for severe spasticity of cerebral origin. J Neurosurg. 2003; 98(2): 291-295. doi:10.3171/jns.2003.98.2.0291
- 152Albright AL, Barron WB, Fasick MP, Polinko P, Janosky J. Continuous intrathecal baclofen infusion for spasticity of cerebral origin. JAMA. 1993; 270(20): 2475-2477. doi:10.1001/jama.1993.03510200081036
- 153Penn RD, Kroin JS. Long-term intrathecal baclofen infusion for treatment of spasticity. J Neurosurg. 1987; 66(2): 181-185. doi:10.3171/jns.1987.66.2.0181
- 154Ordia JI, Fischer E, Adamski E, Spatz EL. Chronic intrathecal delivery of baclofen by a programmable pump for the treatment of severe spasticity. J Neurosurg. 1996; 85(3): 452-457. doi:10.3171/jns.1996.85.3.0452
- 155Ordia JI, Fischer E, Adamski E, Chagnon KG, Spatz EL. Continuous intrathecal baclofen infusion by a programmable pump in 131 consecutive patients with severe spasticity of spinal origin. Neuromodulation. 2002; 5(1): 16-24. doi:10.1046/j.1525-1403.2002._2004.x
- 156Becker R, Alberti O, Bauer BL. Continuous intrathecal baclofen infusion in severe spasticity after traumatic or hypoxic brain injury. J Neurol. 1997; 244(3): 160-166. doi:10.1007/s004150050067
- 157Saulino M, Ivanhoe CB, McGuire JR, Ridley B, Shilt JS, Boster AL. Best practices for intrathecal baclofen therapy: patient selection. Neuromodulation. 2016; 19(6): 607-615. doi:10.1111/ner.12447
- 158Hoarau X, Richer E, Dehail P, Cuny E. Comparison of long-term outcomes of patients with severe traumatic or hypoxic brain injuries treated with intrathecal baclofen therapy for dysautonomia. Brain Inj. 2012; 26(12): 1451-1463. doi:10.3109/02699052.2012.694564
- 159Boster AL, Bennett SE, Bilsky GS, et al. Best practices for intrathecal baclofen therapy: screening test. Neuromodulation. 2016; 19(6): 616-622. doi:10.1111/ner.12437
- 160Francisco GE, Saulino MF, Yablon SA, Turner M. Intrathecal baclofen therapy: an update. PM R. 2009; 1(9): 852-858. doi:10.1016/j.pmrj.2009.07.015
- 161Burns AS, Meythaler JM. Intrathecal baclofen in tetraplegia of spinal origin: efficacy for upper extremity hypertonia. Spinal Cord. 2001; 39(8): 413-419. doi:10.1038/sj.sc.3101178
- 162Grabb PA, Guin-Renfroe S, Meythaler JM. Midthoracic catheter tip placement for intrathecal baclofen administration in children with quadriparetic spasticity. Neurosurgery. 1999; 45(4): 833-837. doi:10.1097/00006123-199910000-00020
- 163 Medtronic. MRI Guidelines for Medtronic Implantable Infusion Systems. Medtronic Inc.; 2020: 1-18 https://mriquestions.com/uploads/3/4/5/7/34572113/synchromed_ii_mri_m005186c_a_001_view.pdf (Accessed on 9/25/23)
- 164 Flowonix. Prometra® and Prometra® II Programmable Pumps Magnetic Resonance Imaging (MRI) Safety Information. Flowonix: 2017; 1-10. https://flowonix.com/sites/default/files/pl-15200-02_-_prometra_and_prometra_ii_programmable_pumps_mri_scan_instructions.pdf (Accessed on 9/25/23)
- 165McCormick ZL, Chu SK, Binler D, et al. Intrathecal versus oral baclofen: a matched cohort study of spasticity, pain, sleep, fatigue, and quality of life. PM R. 2016; 8(6): 553-562. doi:10.1016/j.pmrj.2015.10.005
- 166Pucks-Faes E, Dobesberger J, Hitzenberger G, et al. Intrathecal baclofen in hereditary spastic paraparesis. Front Neurol. 2019; 10: 901. doi:10.3389/fneur.2019.00901
- 167Abbatemarco JR, Willis MA, Wilson RG, Nagel SJ, Machado AG, Bethoux FA. Case series: intrathecal baclofen therapy in stiff-person syndrome. Neuromodulation. 2018; 21(7): 655-659. doi:10.1111/ner.12765
- 168Penn RD, Mangieri EA. Stiff-man syndrome treated with intrathecal baclofen. Neurology. 1993; 43(11): 2412. doi:10.1212/wnl.43.11.2412
- 169Patatoukas D, Rovlias A, Moumtzi H, et al. Hereditary spastic paraparesis and intrathecal baclofen. Ann Phys Rehabil Med. 2014; 57:e49. doi:10.1016/j.rehab.2014.03.177
10.1016/j.rehab.2014.03.177 Google Scholar
- 170Wang KK, Munger ME, Chen BP, Novacheck TF. Selective dorsal rhizotomy in ambulant children with cerebral palsy. J Child Orthop. 2018; 12(5): 413-427. doi:10.1302/1863-2548.12.180123
- 171Peacock WJ, Arens LJ. Selective posterior rhizotomy for the relief of spasticity in cerebral palsy. S Afr Med J. 1982; 62(4): 119-124.
- 172Park TS, Johnston JM. Surgical techniques of selective dorsal rhizotomy for spastic cerebral palsy. Technical note. Neurosurg Focus. 2006; 21(2):e7.
- 173Graham D, Aquilina K, Cawker S, Paget S, Wimalasundera N. Single-level selective dorsal rhizotomy for spastic cerebral palsy. J Spine Surg. 2016; 2(3): 195-201. doi:10.21037/jss.2016.08.08
- 174Josenby AL, Wagner P, Jarnlo GB, Westbom L, Nordmark E. Motor function after selective dorsal rhizotomy: a 10-year practice-based follow-up study. Dev Med Child Neurol. 2012; 54(5): 429-435. doi:10.1111/j.1469-8749.2012.04258.x
- 175Farmer JP, Sabbagh AJ. Selective dorsal rhizotomies in the treatment of spasticity related to cerebral palsy. Childs Nerv Syst. 2007; 23(9): 991-1002. doi:10.1007/s00381-007-0398-2
- 176Tedroff K, Löwing K, Åström E. A prospective cohort study investigating gross motor function, pain, and health-related quality of life 17 years after selective dorsal rhizotomy in cerebral palsy. Dev Med Child Neurol. 2015; 57(5): 484-490. doi:10.1111/dmcn.12665
- 177Hägglund G, Wagner P. Development of spasticity with age in a total population of children with cerebral palsy. BMC Musculoskelet Disord. 2008; 9: 150. doi:10.1186/1471-2474-9-150
- 178Munger ME, Aldahondo N, Krach LE, Novacheck TF, Schwartz MH. Long-term outcomes after selective dorsal rhizotomy: a retrospective matched cohort study. Dev Med Child Neurol. 2017; 59(11): 1196-1203. doi:10.1111/dmcn.13500
- 179Dudley RW, Parolin M, Gagnon B, et al. Long-term functional benefits of selective dorsal rhizotomy for spastic cerebral palsy. J Neurosurg Pediatr. 2013; 12(2): 142-150. doi:10.3171/2013.4.PEDS12539
- 180Tedroff K, Hägglund G, Miller F. Long-term effects of selective dorsal rhizotomy in children with cerebral palsy: a systematic review. Dev Med Child Neurol. 2020; 62(5): 554-562. doi:10.1111/dmcn.14320
- 181Grootveld LR, van Schie PE, Buizer AI, et al. Sudden falls as a persistent complication of selective dorsal rhizotomy surgery in children with bilateral spasticity: report of 3 cases. J Neurosurg Pediatr. 2016; 18(2): 192-195. doi:10.3171/2016.2.PEDS15527
- 182McLaughlin J, Bjornson K, Temkin N, et al. Selective dorsal rhizotomy: meta-analysis of three randomized controlled trials. Dev Med Child Neurol. 2002; 44(1): 17-25. doi:10.1017/s0012162201001608
- 183Daunter AK, Kratz AL, Hurvitz EA. Long-term impact of childhood selective dorsal rhizotomy on pain, fatigue, and function: a case-control study. Dev Med Child Neurol. 2017; 59(10): 1089-1095. doi:10.1111/dmcn.13481
- 184Bolster EA, van Schie PE, Becher JG, van Ouwerkerk WJ, Strijers RL, Vermeulen RJ. Long-term effect of selective dorsal rhizotomy on gross motor function in ambulant children with spastic bilateral cerebral palsy, compared with reference centiles. Dev Med Child Neurol. 2013; 55(7): 610-616. doi:10.1111/dmcn.12148
- 185Summers J, Coker B, Eddy S, et al. Selective dorsal rhizotomy in ambulant children with cerebral palsy: an observational cohort study. Lancet Child Adolesc Health. 2019; 3(7): 455-462. doi:10.1016/S2352-4642(19)30119-1
- 186Trost JP, Schwartz MH, Krach LE, Dunn ME, Novacheck TF. Comprehensive short-term outcome assessment of selective dorsal rhizotomy. Dev Med Child Neurol. 2008; 50(10): 765-771. doi:10.1111/j.1469-8749.2008.03031.x
- 187Novak I, McIntyre S, Morgan C, et al. A systematic review of interventions for children with cerebral palsy: state of the evidence. Dev Med Child Neurol. 2013; 55(10): 885-910. doi:10.1111/dmcn.12246
- 188Wach J, Yildiz ÖC, Sarikaya-Seiwert S, Vatter H, Haberl H. Predictors of postoperative complications after selective dorsal rhizotomy. Acta Neurochir. 2021; 163(2): 463-474. doi:10.1007/s00701-020-04487-3
- 189Aldahondo N, Krach LE. Poster 447 dysesthesias after selective dorsal rhizotomy: risk factors, presentation, and treatment. PM&R. 2012; 4(S10): S343-S344. doi:10.1016/j.pmrj.2012.09.1055
10.1016/j.pmrj.2012.09.1055 Google Scholar
- 190Geiduschek JM, Haberkern CM, McLaughlin JF, Jacobson LE, Hays RM, Roberts TS. Pain management for children following selective dorsal rhizotomy. Can J Anaesth. 1994; 41(6): 492-496. doi:10.1007/BF03011543
- 191Abdel Ghany WA, Nada M, Mahran MA, et al. Combined anterior and posterior lumbar rhizotomy for treatment of mixed dystonia and spasticity in children with cerebral palsy. Neurosurgery. 2016; 79(3): 336-344. doi:10.1227/NEU.0000000000001271
- 192Albright AL, Tyler-Kabara EC. Combined ventral and dorsal rhizotomies for dystonic and spastic extremities. Report of six cases. J Neurosurg. 2007; 107(4 Suppl): 324-327. doi:10.3171/PED-07/10/324
- 193Merlo A, Galletti M, Zerbinati P, et al. Surgical quadriceps lengthening can reduce quadriceps spasticity in chronic stroke patients. A case-control study. Front Neurol. 2022; 13:980692. doi:10.3389/fneur.2022.980692
- 194Chang CH, Chen YY, Yeh KK, Chen CL. Gross motor function change after multilevel soft tissue release in children with cerebral palsy. Biom J. 2017; 40(3): 163-168. doi:10.1016/j.bj.2016.12.003
10.1016/j.bj.2016.12.003 Google Scholar
- 195Ellington MD, Scott AC, Linton J, Sullivan E, Barnes D. Rectus emoris transfer versus rectus intramuscular lengthening for the treatment of stiff knee gait in children with cerebral palsy. J Pediatr Orthop. 2018; 38(4): e213-e218. doi:10.1097/BPO.0000000000001138
- 196Kläusler M, Speth BM, Brunner R, Tirosh O, Camathias C, Rutz E. Long-term follow-up after tibialis anterior tendon shortening in combination with Achilles tendon lengthening in spastic equinus in cerebral palsy. Gait Posture. 2017; 58: 457-462. doi:10.1016/j.gaitpost.2017.08.028
- 197Leclercq C, Perruisseau-Carrier A, Gras M, Panciera P, Fulchignoni C, Fulchignoni M. Hyperselective neurectomy for the treatment of upper limb spasticity in adults and children: a prospective study. J Hand Surg Eur. 2021; 46(7): 708-716. doi:10.1177/17531934211027499
- 198Bollens B, Deltombe T, Detrembleur C, Gustin T, Stoquart G, Lejeune TM. Effects of selective tibial nerve neurotomy as a treatment for adults presenting with spastic equinovarus foot: a systematic review. J Rehabil Med. 2011; 43(4): 277-282. doi:10.2340/16501977-0786
- 199Thibaut A, Wannez S, Deltombe T, Martens G, Laureys S, Chatelle C. Physical therapy in patients with disorders of consciousness: impact on spasticity and muscle contracture. NeuroRehabilitation. 2018; 42(2): 199-205. doi:10.3233/NRE-172229
- 200Thibaut A, Chatelle C, Ziegler E, Bruno MA, Laureys S, Gosseries O. Spasticity after stroke: physiology, assessment and treatment. Brain Inj. 2013; 27(10): 1093-1105. doi:10.3109/02699052.2013.804202
- 201Morgan C, Fetters L, Adde L, et al. Early intervention for children aged 0 to 2 years with or at high risk of cerebral palsy: international clinical practice guideline based on systematic reviews. JAMA Pediatr. 2021; 175(8): 846-858. doi:10.1001/jamapediatrics.2021.0878
- 202Morgan C, Darrah J, Gordon AM, et al. Effectiveness of motor interventions in infants with cerebral palsy: a systematic review. Dev Med Child Neurol. 2016; 58(9): 900-909. doi:10.1111/dmcn.13105
- 203Bovend'Eerdt TJ, Newman M, Barker K, Dawes H, Minelli C, Wade DT. The effects of stretching in spasticity: a systematic review. Arch Phys Med Rehabil. 2008; 89(7): 1395-1406. doi:10.1016/j.apmr.2008.02.015
- 204Katalinic OM, Harvey LA, Herbert RD, Moseley AM, Lannin NA, Schurr K. Stretch for the treatment and prevention of contractures. Cochrane Database Syst Rev. 2010; 1(9):CD007455. doi:10.1002/14651858.CD007455.pub2
10.1002/14651858.CD007455.pub2 Google Scholar
- 205Katalinic OM, Harvey LA, Herbert RD. Effectiveness of stretch for the treatment and prevention of contractures in people with neurological conditions: a systematic review. Phys Ther. 2011; 91(1): 11-24. doi:10.2522/ptj.20100265
- 206Pin T, Dyke P, Chan M. The effectiveness of passive stretching in children with cerebral palsy. Dev Med Child Neurol. 2006; 48(10): 855-862. doi:10.1017/S0012162206001836
- 207Salazar AP, Pinto C, Ruschel Mossi JV, Figueiro B, Lukrafka JL, Pagnussat AS. Effectiveness of static stretching positioning on post-stroke upper-limb spasticity and mobility: systematic review with meta-analysis. Ann Phys Rehabil Med. 2019; 62(4): 274-282. doi:10.1016/j.rehab.2018.11.004
- 208Booth MY, Yates CC, Edgar TS, Bandy WD. Serial casting vs combined intervention with botulinum toxin A and serial casting in the treatment of spastic equinus in children. Pediatr Phys Ther. 2003; 15(4): 216-220. doi:10.1097/01.PEP.0000096382.65499.E2
- 209Dai AI, Demiryürek AT. Serial casting as an adjunct to botulinum toxin type A treatment in children with cerebral palsy and spastic paraparesis with scissoring of the lower extremities. J Child Neurol. 2017; 32(7): 671-675. doi:10.1177/0883073817701526
- 210Lee SJ, Sung IY, Jang DH, Yi JH, Lee JH, Ryu JS. The effect and complication of botulinum toxin type a injection with serial casting for the treatment of spastic equinus foot. Ann Rehabil Med. 2011; 35(3): 344-353. doi:10.5535/arm.2011.35.3.344
- 211Glanzman AM, Kim H, Swaminathan K, Beck T. Efficacy of botulinum toxin A, serial casting, and combined treatment for spastic equinus: a retrospective analysis. Dev Med Child Neurol. 2004; 46(12): 807-811. doi:10.1017/s0012162204001410
- 212Amatya B, Khan F, La Mantia L, Demetrios M, Wade DT. Non pharmacological interventions for spasticity in multiple sclerosis. Cochrane Database Syst Rev. 2013; 2(2):CD009974. doi:10.1002/14651858.CD009974.pub2
10.1002/14651858.CD009974.pub2 Google Scholar
- 213Merino-Andrés J, García de Mateos-López A, Damiano DL, Sánchez-Sierra A. Effect of muscle strength training in children and adolescents with spastic cerebral palsy: a systematic review and meta-analysis. Clin Rehabil. 2022; 36(1): 4-14. doi:10.1177/02692155211040199
- 214Rogers A, Furler BL, Brinks S, Darrah J. A systematic review of the effectiveness of aerobic exercise interventions for children with cerebral palsy: an AACPDM evidence report. Dev Med Child Neurol. 2008; 50(11): 808-814. doi:10.1111/j.1469-8749.2008.03134.x
- 215Hoare BJ, Wallen MA, Thorley MN, Jackman ML, Carey LM, Imms C. Constraint-induced movement therapy in children with unilateral cerebral palsy. Cochrane Database Syst Rev. 2019; 4(4):CD004149. doi:10.1002/14651858.CD004149.pub3
- 216Huang YC, Chen PC, Tso HH, Yang YC, Ho TL, Leong CP. Effects of kinesio taping on hemiplegic hand in patients with upper limb post-stroke spasticity: a randomized controlled pilot study. Eur J Phys Rehabil Med. 2019; 55(5): 551-557. doi:10.23736/S1973-9087.19.05684-3
- 217Santamato A, Micello MF, Panza F, et al. Adhesive taping vs. daily manual muscle stretching and splinting after botulinum toxin type A injection for wrist and fingers spastic overactivity in stroke patients: a randomized controlled trial. Clin Rehabil. 2015; 29(1): 50-58. doi:10.1177/0269215514537915
- 218Woodford H, Price C. EMG biofeedback for the recovery of motor function after stroke. Cochrane Database Syst Rev. 2007; 2007(2):CD004585. doi:10.1002/14651858.CD004585.pub2
- 219Winstein CJ, Stein J, Arena R, et al. Guidelines for adult stroke rehabilitation and recovery: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2016; 47(6): e98-e169. doi:10.1161/STR.0000000000000098 Erratum in: Stroke. 2017;48(2):e78. Erratum in: Stroke. 2017;48(12):e369.
- 220Stein C, Fritsch CG, Robinson C, Sbruzzi G, Plentz RD. Effects of electrical stimulation in spastic muscles after stroke: systematic review and meta-analysis of randomized controlled trials. Stroke. 2015; 46(8): 2197-2205. doi:10.1161/STROKEAHA.115.009633
- 221Intiso D, Santamato A, Di Rienzo F. Effect of electrical stimulation as an adjunct to botulinum toxin type A in the treatment of adult spasticity: a systematic review. Disabil Rehabil. 2017; 39(21): 2123-2133. doi:10.1080/09638288.2016.1219398
- 222Korzhova J, Sinitsyn D, Chervyakov A, et al. Transcranial and spinal cord magnetic stimulation in treatment of spasticity: a literature review and meta-analysis. Eur J Phys Rehabil Med. 2018; 54(1): 75-84. doi:10.23736/S1973-9087.16.04433-6
- 223Mills PB, Dossa F. Transcutaneous electrical nerve stimulation for management of limb spasticity: a systematic review. Am J Phys Med Rehabil. 2016; 95(4): 309-318. doi:10.1097/PHM.0000000000000437
- 224Fang CY, Lien AS, Tsai JL, et al. The effect and dose-response of functional electrical stimulation cycling training on spasticity in individuals with spinal cord injury: a systematic review with meta-analysis. Front Physiol. 2021; 12:756200. doi:10.3389/fphys.2021.756200
- 225Alcantara CC, Blanco J, De Oliveira LM, et al. Cryotherapy reduces muscle hypertonia, but does not affect lower limb strength or gait kinematics post-stroke: a randomized controlled crossover study. Top Stroke Rehabil. 2019; 26(4): 267-280. doi:10.1080/10749357.2019.1593613
- 226Garcia LC, Alcântara CC, Santos GL, Monção JVA, Russo TL. Cryotherapy reduces muscle spasticity but does not affect proprioception in ischemic stroke: a randomized sham-controlled crossover study. Am J Phys Med Rehabil. 2019; 98(1): 51-57. doi:10.1097/PHM.0000000000001024
- 227Winston P, MacRae F, Rajapakshe S, et al. Analysis of adverse effects of cryoneurolysis for the treatment of spasticity. Am J Phys Med Rehabil. 2023; 102(11): 1008-1013. doi:10.1097/PHM.0000000000002267
- 228Gracies JM. Physical modalities other than stretch in spastic hypertonia. Phys Med Rehabil Clin N Am. 2001; 12(4): 769-vi.
- 229Smania N, Picelli A, Munari D, et al. Rehabilitation procedures in the management of spasticity. Eur J Phys Rehabil Med. 2010; 46(3): 423-438.
- 230Fernández-de-Las-Peñas C, Pérez-Bellmunt A, Llurda-Almuzara L, Plaza-Manzano G, De-la-Llave-Rincón AI, Navarro-Santana MJ. Is dry needling effective for the management of spasticity, pain, and motor function in post-stroke patients? A systematic review and meta-analysis. Pain Med. 2021; 22(1): 131-141. doi:10.1093/pm/pnaa392
- 231Tang L, Li Y, Huang QM, Yang Y. Dry needling at myofascial trigger points mitigates chronic post-stroke shoulder spasticity. Neural Regen Res. 2018; 13(4): 673-676. doi:10.4103/1673-5374.230293
- 232Hadi S, Khadijeh O, Hadian M, et al. The effect of dry needling on spasticity, gait and muscle architecture in patients with chronic stroke: a case series study. Top Stroke Rehabil. 2018; 25(5): 326-332. doi:10.1080/10749357.2018.1460946
- 233Cai Y, Zhang CS, Liu S, et al. Electroacupuncture for poststroke spasticity: a systematic review and meta-analysis. Arch Phys Med Rehabil. 2017; 98(12): 2578-2589. doi:10.1016/j.apmr.2017.03.023
- 234Zhu Y, Yang Y, Li J. Does acupuncture help patients with spasticity? A narrative review. Ann Phys Rehabil Med. 2019; 62(4): 297-301. doi:10.1016/j.rehab.2018.09.010
- 235Howard IM, Patel AT. Spasticity evaluation and management tools. Muscle Nerve. 2023; 67(4): 272-283. doi:10.1002/mus.27792
- 236Franzini A, Cordella R, Nazzi V, Broggi G. Long-term chronic stimulation of internal capsule in poststroke pain and spasticity. Case report, long-term results and review of the literature. Stereotact Funct Neurosurg. 2008; 86(3): 179-183. doi:10.1159/000120431