Radiation-induced osteosarcoma in a patient with DICER1 syndrome
Kazuki Tanimura
Department of Pediatric Hematology/Oncology, Osaka City General Hospital, Osaka, Japan
Department of Pediatric Oncology, National Cancer Center Hospital, Tokyo, Japan
Search for more papers by this authorCorresponding Author
Yoshiko Nakano
Department of Pediatric Hematology/Oncology, Osaka City General Hospital, Osaka, Japan
Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Correspondence
Yoshiko Nakano, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Email: [email protected]
Search for more papers by this authorAiko Sato-Otsubo
Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Search for more papers by this authorKai Yamasaki
Department of Pediatric Hematology/Oncology, Osaka City General Hospital, Osaka, Japan
Search for more papers by this authorHiroko Fukushima
Department of Diagnostic Pathology, Osaka City Juso Hospital, Osaka, Japan
Department of Diagnostic Pathology, Osaka City General Hospital, Osaka, Japan
Search for more papers by this authorMio Tanaka
Department of Pathology, Kanagawa Children's Medical Center, Yokohama, Kanagawa, Japan
Search for more papers by this authorTakako Yoshioka
Department of Pathology, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorHazime Okita
Division of Diagnostic Pathology, Keio University, Tokyo, Japan
Search for more papers by this authorNoritsugu Kunihiro
Division of Pediatric Neurosurgery, Osaka City General Hospital, Osaka, Japan
Search for more papers by this authorHiroaki Sakamoto
Division of Pediatric Neurosurgery, Osaka City General Hospital, Osaka, Japan
Search for more papers by this authorTakeshi Inoue
Department of Diagnostic Pathology, Osaka City General Hospital, Osaka, Japan
Search for more papers by this authorHiroyuki Fujisaki
Department of Pediatric Hematology/Oncology, Osaka City General Hospital, Osaka, Japan
Search for more papers by this authorJunichi Hara
Department of Pediatric Hematology/Oncology, Osaka City General Hospital, Osaka, Japan
Search for more papers by this authorKazuki Tanimura
Department of Pediatric Hematology/Oncology, Osaka City General Hospital, Osaka, Japan
Department of Pediatric Oncology, National Cancer Center Hospital, Tokyo, Japan
Search for more papers by this authorCorresponding Author
Yoshiko Nakano
Department of Pediatric Hematology/Oncology, Osaka City General Hospital, Osaka, Japan
Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Correspondence
Yoshiko Nakano, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Email: [email protected]
Search for more papers by this authorAiko Sato-Otsubo
Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Search for more papers by this authorKai Yamasaki
Department of Pediatric Hematology/Oncology, Osaka City General Hospital, Osaka, Japan
Search for more papers by this authorHiroko Fukushima
Department of Diagnostic Pathology, Osaka City Juso Hospital, Osaka, Japan
Department of Diagnostic Pathology, Osaka City General Hospital, Osaka, Japan
Search for more papers by this authorMio Tanaka
Department of Pathology, Kanagawa Children's Medical Center, Yokohama, Kanagawa, Japan
Search for more papers by this authorTakako Yoshioka
Department of Pathology, National Center for Child Health and Development, Tokyo, Japan
Search for more papers by this authorHazime Okita
Division of Diagnostic Pathology, Keio University, Tokyo, Japan
Search for more papers by this authorNoritsugu Kunihiro
Division of Pediatric Neurosurgery, Osaka City General Hospital, Osaka, Japan
Search for more papers by this authorHiroaki Sakamoto
Division of Pediatric Neurosurgery, Osaka City General Hospital, Osaka, Japan
Search for more papers by this authorTakeshi Inoue
Department of Diagnostic Pathology, Osaka City General Hospital, Osaka, Japan
Search for more papers by this authorHiroyuki Fujisaki
Department of Pediatric Hematology/Oncology, Osaka City General Hospital, Osaka, Japan
Search for more papers by this authorJunichi Hara
Department of Pediatric Hematology/Oncology, Osaka City General Hospital, Osaka, Japan
Search for more papers by this authorKazuki Tanimura and Yoshiko Nakano contributed equally to this work.
CONFLICT OF INTEREST
The authors declare that there is no conflict of interest associated with this work.
Supporting Information
| Filename | Description |
|---|---|
| pbc29782-sup-0001-FigS1.pdf90 KB | Supporting Figure S1 MRI findings of a sinonasal lesion. A mass in the nasal cavity was detected at age 7 years (A), differential diagnosis for which includes nasal chondromesenchymal hamartoma. Follow-up MRI at age 8 years (B) and 10 years (C and D) |
| pbc29782-sup-0002-FigS2.pdf272.6 KB | Supporting Figure S2 Results of copy number analysis. (A) Copy number alternations in three different samples. Frequency of copy number alternation detected in the osteosarcoma sample was relatively high. (B) Copy number loss was detected in TP53 locus in the osteosarcoma |
| pbc29782-sup-0003-SuppMat.docx20.4 KB | Supporting Material |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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