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Prolonged neutropenia due to antihuman neutrophil antigen 2 (CD177) antibody after bone marrow transplantation

Corresponding Author

Taizo Wada

[email protected]

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

Correspondence

Taizo Wada, Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa 920–8641, Japan.

Email: [email protected]

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Satoshi Miyamoto,

Satoshi Miyamoto

Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan

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Hiroyuki Okamoto,

Hiroyuki Okamoto

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

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Yusuke Matsuda,

Yusuke Matsuda

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

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Tomoko Toma,

Tomoko Toma

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

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Kohsuke Imai,

Kohsuke Imai

Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan

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Masatoshi Takagi,

Masatoshi Takagi

Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan

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Tomohiro Morio,

Tomohiro Morio

Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan

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Akihiro Yachie,

Akihiro Yachie

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

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Taizo Wada,

Corresponding Author

Taizo Wada

[email protected]

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

Correspondence

Taizo Wada, Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa 920–8641, Japan.

Email: [email protected]

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Satoshi Miyamoto,

Satoshi Miyamoto

Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan

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Hiroyuki Okamoto,

Hiroyuki Okamoto

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

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Yusuke Matsuda,

Yusuke Matsuda

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

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Tomoko Toma,

Tomoko Toma

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

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Kohsuke Imai,

Kohsuke Imai

Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan

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Masatoshi Takagi,

Masatoshi Takagi

Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan

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Tomohiro Morio,

Tomohiro Morio

Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan

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Akihiro Yachie,

Akihiro Yachie

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

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First published: 01 December 2016

https://doi.org/10.1002/pbc.26388

Citations: 8

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Abstract

We describe a patient who presented with prolonged neutropenia due to anti-human neutrophil antigen (HNA)-2 (CD177) antibody after allogeneic bone marrow transplantation. A granulocyte immunofluorescence test showed bimodal expression of antineutrophil antibody that resulted from specific binding of anti-HNA-2 to CD177⁺ neutrophils from healthy donors. The patient did not respond to granulocyte colony stimulating factor, which is able to upregulate CD177 expression on neutrophils. The low percentage of CD177⁺ cells in the few remaining neutrophils supports the possibility of elimination of CD177-upregulated neutrophils. These findings might explain an inferior response to neutrophil growth factors in neutropenia secondary to anti-HNA-2 antibody.

REFERENCES

1Bux J. Human neutrophil alloantigens. Vox Sang. 2008; 94(4): 277–285.
10.1111/j.1423-0410.2007.01031.x
CAS PubMed Web of Science® Google Scholar
2Veldhuisen B, Porcelijn L, Ellen van der Schoot C, et al. Molecular typing of human platelet and neutrophil antigens (HPA and HNA). Transfus Apher Sci. 2014; 50(2): 189–199.
10.1016/j.transci.2014.02.014
PubMed Web of Science® Google Scholar
3Fung YL, Minchinton RM, Fraser JF. Neutrophil antibody diagnostics and screening: review of the classical versus the emerging. Vox Sang. 2011; 101(4): 282–290.
10.1111/j.1423-0410.2011.01511.x
CAS PubMed Web of Science® Google Scholar
4Clay ME, Schuller RM, Bachowski GJ. Granulocyte serology: current concepts and clinical significance. Immunohematology. 2010; 26(1): 11–21.
PubMed Google Scholar
5Stroncek DF. Neutrophil-specific antigen HNA-2a, NB1 glycoprotein, and CD177. Curr Opin Hematol. 2007; 14(6): 688–693.
10.1097/MOH.0b013e3282efed9e
CAS PubMed Web of Science® Google Scholar
6Lalezari P, Murphy GB, Allen FH, Jr. NB1, a new neutrophil-specific antigen involved in the pathogenesis of neonatal neutropenia. J Clin Invest. 1971; 50(5): 1108–1115.
10.1172/JCI106582
CAS PubMed Web of Science® Google Scholar
7Bux J, Becker F, Seeger W, et al. Transfusion-related acute lung injury due to HLA-A2-specific antibodies in recipient and NB1-specific antibodies in donor blood. Br J Haematol. 1996; 93(3): 707–713.
10.1046/j.1365-2141.1996.d01-1703.x
CAS PubMed Web of Science® Google Scholar
8Sachs UJ, Hattar K, Weissmann N, et al. Antibody-induced neutrophil activation as a trigger for transfusion-related acute lung injury in an ex vivo rat lung model. Blood. 2006; 107(3): 1217–1219.
10.1182/blood-2005-04-1744
CAS PubMed Web of Science® Google Scholar
9Stroncek DF, Shapiro RS, Filipovich AH, et al. Prolonged neutropenia resulting from antibodies to neutrophil-specific antigen NB1 following marrow transplantation. Transfusion. 1993; 33(2): 158–163.
10.1046/j.1537-2995.1993.33293158050.x
CAS PubMed Web of Science® Google Scholar
10Pocock CF, Lucas GF, Giles C, et al. Immune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies following unrelated donor stem cell transplantation for chronic myeloid leukaemia: perpetuation by granulocyte colony-stimulating factor. Br J Haematol. 2001; 113(2): 483–485.
10.1046/j.1365-2141.2001.02779.x
CAS PubMed Web of Science® Google Scholar
11Bauer S, Abdgawad M, Gunnarsson L, et al. Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophils. J Leukoc Biol. 2007; 81(2): 458–464.
10.1189/jlb.0806514
CAS PubMed Web of Science® Google Scholar
12Matsuo K, Lin A, Procter JL, et al. Variations in the expression of granulocyte antigen NB1. Transfusion. 2000; 40(6): 654–662.
10.1046/j.1537-2995.2000.40060654.x
CAS PubMed Web of Science® Google Scholar
13Maheshwari A, Christensen RD, Calhoun DA. Resistance to recombinant human granulocyte colony-stimulating factor in neonatal alloimmune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies. Pediatrics. 2002; 109(4): e64.
10.1542/peds.109.4.e64
PubMed Web of Science® Google Scholar
14Tomicic M, Starcevic M, Zach V, et al. Alloimmune neonatal neutropenia due to anti-HNA-2a alloimmunization with severe and prolonged neutropenia but mild clinical course: two case reports. Arch Med Res. 2007; 38(7): 792–796.
10.1016/j.arcmed.2007.03.010
CAS PubMed Web of Science® Google Scholar
15Stroncek DF, Jaszcz W, Herr GP, et al. Expression of neutrophil antigens after 10 days of granulocyte-colony-stimulating factor. Transfusion. 1998; 38(7): 663–668.
10.1046/j.1537-2995.1998.38798346635.x
CAS PubMed Web of Science® Google Scholar

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Volume64, Issue7

July 2017

e26388

Prolonged neutropenia due to antihuman neutrophil antigen 2 (CD177) antibody after bone marrow transplantation

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Prolonged neutropenia due to antihuman neutrophil antigen 2 (CD177) antibody after bone marrow transplantation

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