Clinical, histologic, and genetic features of mesothelioma in a 7-Year-old child
Aaron Sugalski DO
Department of Pediatrics and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas
Search for more papers by this authorMary Davis MD
Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids, Michigan
Search for more papers by this authorLatha Prasannan MD
Covenant Children's Hospital, Lubbock, Texas
Search for more papers by this authorVictor Saldivar MD
CHRISTUS Santa Rosa Children's Hospital, San Antonio, Texas
Search for more papers by this authorJaclyn Y. Hung PhD
Department of Pediatrics and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas
Search for more papers by this authorCorresponding Author
Gail E. Tomlinson MD, PhD
Department of Pediatrics and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas
Department of Pediatrics and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Drive, San Antonio, TX 78229.===Search for more papers by this authorAaron Sugalski DO
Department of Pediatrics and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas
Search for more papers by this authorMary Davis MD
Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids, Michigan
Search for more papers by this authorLatha Prasannan MD
Covenant Children's Hospital, Lubbock, Texas
Search for more papers by this authorVictor Saldivar MD
CHRISTUS Santa Rosa Children's Hospital, San Antonio, Texas
Search for more papers by this authorJaclyn Y. Hung PhD
Department of Pediatrics and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas
Search for more papers by this authorCorresponding Author
Gail E. Tomlinson MD, PhD
Department of Pediatrics and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas
Department of Pediatrics and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Drive, San Antonio, TX 78229.===Search for more papers by this authorAbstract
Malignant mesothelioma (MM) is a highly aggressive malignancy that is extremely rare in children. This case report documents a 7-year-old male without previous asbestos exposure with peritoneal MM that initially responded to chemotherapy with cisplatin and gemcitabine but ultimately metastasized to his chest. He was diagnosed with MM based on histology, extensive immunohistochemical analyses, and an elevated serum CA-125 level. Cytogenetics and comparative genomic hybridization (CGH) analysis of his tumor identified a single extra copy number of chromosome 11 with few other changes noted. Pediatr Blood Cancer 2013; 60: 146–148. © 2012 Wiley Periodicals, Inc.
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