Review
Assembly of bioinspired helical protein fibers
Susheel Kumar Gunasekar,
Jennifer Shorah Haghpanah,
Jin Kim Montclare,
Susheel Kumar Gunasekar
Department of Chemical and Biological Sciences, Polytechnic University, Brooklyn, NY 11201, USA
Search for more papers by this authorJennifer Shorah Haghpanah
Department of Chemical and Biological Sciences, Polytechnic University, Brooklyn, NY 11201, USA
Search for more papers by this authorCorresponding Author
Jin Kim Montclare
Department of Chemical and Biological Sciences, Polytechnic University, Brooklyn, NY 11201, USA
Department of Biochemistry, SUNY-Downstate Medical Center, Brooklyn, NY 11203, USA
Department of Chemical and Biological Sciences, Polytechnic University, Brooklyn, NY 11201, USA.Search for more papers by this authorSusheel Kumar Gunasekar,
Jennifer Shorah Haghpanah,
Jin Kim Montclare,
Susheel Kumar Gunasekar
Department of Chemical and Biological Sciences, Polytechnic University, Brooklyn, NY 11201, USA
Search for more papers by this authorJennifer Shorah Haghpanah
Department of Chemical and Biological Sciences, Polytechnic University, Brooklyn, NY 11201, USA
Search for more papers by this authorCorresponding Author
Jin Kim Montclare
Department of Chemical and Biological Sciences, Polytechnic University, Brooklyn, NY 11201, USA
Department of Biochemistry, SUNY-Downstate Medical Center, Brooklyn, NY 11203, USA
Department of Chemical and Biological Sciences, Polytechnic University, Brooklyn, NY 11201, USA.Search for more papers by this authorAbstract
Advances in protein and peptide technologies not only enable the study of basic folding and function of natural structures but also the design of novel scaffolds with the ability to form assemblies of varied shapes and sizes. Tremendous progress has been made in our understanding of α-helices in nature especially in the context of the coiled-coil. The information gleaned from investigating coiled- coils has been used to design novel α-helical fibers with prescribed morphology and dimensions. This review focuses on the lessons learned from the assembly of natural coiled-coils and how this knowledge can be used to tailor helical fibers as novel bioinspired materials. Copyright © 2008 John Wiley & Sons, Ltd.
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