Volume 37, Issue 4 pp. 1501-1505
ORIGINAL CLINICAL ARTICLE

Signs and symptoms that distinguish detrusor underactivity from mixed detrusor underactivity and bladder outlet obstruction in male patients

Andrew Gammie

Corresponding Author

Andrew Gammie

Bristol Urological Institute, Southmead Hospital, Bristol, UK

Correspondence

Andrew Gammie, Bristol Urological Institute, Southmead Hospital, Bristol BS10 5NB, UK.

Email: [email protected]

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Mathilde Kaper

Mathilde Kaper

Astellas Pharma Europe BV, Leiden, The Netherlands

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Achim Steup

Achim Steup

Astellas Pharma Europe BV, Leiden, The Netherlands

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Satoshi Yoshida

Satoshi Yoshida

Astellas Pharma Europe BV, Leiden, The Netherlands

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Caroline Dorrepaal

Caroline Dorrepaal

Astellas Pharma Europe BV, Leiden, The Netherlands

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Ton Kos

Ton Kos

Astellas Pharma Europe BV, Leiden, The Netherlands

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Paul Abrams

Paul Abrams

Bristol Urological Institute, Southmead Hospital, Bristol, UK

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First published: 22 January 2018
Citations: 10
The work was undertaken at Bristol Urological Institute and at Astellas Pharma Europe BV.
John Heesakkers led the peer-review process as the Associate Editor responsible for the paper.

Abstract

Aims

This study aimed to identify signs and symptoms which show differences between men with detrusor underactivity (DU) compared to those with both DU and bladder outlet obstruction (BOO).

Methods

One thousand six hundred and twelve urodynamic tests on male patients were analyzed retrospectively. Signs and symptoms which showed a statistically significant difference between patients with DU alone and patients with both DU+BOO were identified.

Results

In the DU only group, considering only patients without a history of bladder outlet surgery, the number of daytime micturitions was lower, maximum voided volume on the bladder diary was higher, and slow stream was reported less often, whereas urinary tract infections were reported more often than for DU+BOO males. The average urine flow rate and abdominal pressure at maximum flow were greater in the DU males, compared to the DU+BOO males.

Conclusions

These data suggest that by combining symptoms, medical history and signs, that could be measured without the need for invasive urodynamics, it may be possible to identify men with DU in a non-invasive way. By doing so, men with DU could be separated from men with both DU+BOO, with sufficient specificity to allow the use of any new non-surgical treatment modalities, such as new and effective medical therapy.

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