CLINICAL RESEARCH ARTICLE

Characteristics of after-discharges following compound muscle action potential or F-wave in primary peripheral nerve hyperexcitability syndrome

Youfang Hu MS

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Contribution: Conceptualization, Methodology, Software, Data curation, Investigation, Validation, Formal analysis, Writing - original draft, Writing - review & editing, Visualization

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Qingyun Ding MS,

Qingyun Ding MS

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Contribution: Methodology, Software, Data curation, Investigation, Formal analysis, Writing - original draft, Validation

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Xinhong Feng MD,

Xinhong Feng MD

orcid.org/0000-0003-2340-8183

Department of Neurology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China

Contribution: Investigation, Formal analysis, Writing - original draft

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Wu Yimin BS,

Wu Yimin BS

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Contribution: Investigation, Methodology, Software, Data curation

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Dongchao Shen MD,

Dongchao Shen MD

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Contribution: Investigation, Methodology, Software, Data curation

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Jiayu Shi MD,

Jiayu Shi MD

orcid.org/0000-0001-7654-3827

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Contribution: Conceptualization, Methodology, Data curation, Writing - original draft

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Shuang Wu BS,

Shuang Wu BS

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Contribution: Investigation, Methodology, Software, Data curation

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Liying Cui MD,

Liying Cui MD

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Contribution: Funding acquisition, Supervision, Project administration, Validation, Conceptualization, Resources

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Yuzhou Guan MD,

Corresponding Author

Yuzhou Guan MD

[email protected]

orcid.org/0000-0003-3822-4440

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Correspondence

Yuzhou Guan, Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Email: [email protected]

Contribution: Funding acquisition, Conceptualization, Supervision, Project administration, Methodology, Validation, Formal analysis, Resources, Writing - review & editing

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Youfang Hu MS,

Youfang Hu MS

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Contribution: Conceptualization, Methodology, Software, Data curation, Investigation, Validation, Formal analysis, Writing - original draft, Writing - review & editing, Visualization

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Qingyun Ding MS,

Qingyun Ding MS

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Contribution: Methodology, Software, Data curation, Investigation, Formal analysis, Writing - original draft, Validation

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Xinhong Feng MD,

Xinhong Feng MD

orcid.org/0000-0003-2340-8183

Department of Neurology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China

Contribution: Investigation, Formal analysis, Writing - original draft

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Wu Yimin BS,

Wu Yimin BS

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Contribution: Investigation, Methodology, Software, Data curation

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Dongchao Shen MD,

Dongchao Shen MD

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Contribution: Investigation, Methodology, Software, Data curation

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Jiayu Shi MD,

Jiayu Shi MD

orcid.org/0000-0001-7654-3827

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Contribution: Conceptualization, Methodology, Data curation, Writing - original draft

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Shuang Wu BS,

Shuang Wu BS

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Contribution: Investigation, Methodology, Software, Data curation

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Liying Cui MD,

Liying Cui MD

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Contribution: Funding acquisition, Supervision, Project administration, Validation, Conceptualization, Resources

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Yuzhou Guan MD,

Corresponding Author

Yuzhou Guan MD

[email protected]

orcid.org/0000-0003-3822-4440

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Correspondence

Yuzhou Guan, Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Email: [email protected]

Contribution: Funding acquisition, Conceptualization, Supervision, Project administration, Methodology, Validation, Formal analysis, Resources, Writing - review & editing

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First published: 31 July 2024

https://doi.org/10.1002/mus.28220

Youfang Hu and Qingyun Ding contributed to the work equally and should be regarded as co-first authors.

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Abstract

Introduction/Aims

F-wave testing frequently reveals after-discharges of varied morphologies in patients with primary peripheral nerve hyperexcitability syndrome (PNHS), although reports are scant. This study aimed to explore the morphological characteristics of the after-discharges during F-wave tests in PNHS, and to assess the association between after-discharges and the disease classification.

Methods

We conducted a retrospective analysis of patients diagnosed with PNHS between 2014 and 2022. The morphological characteristic and duration of after-discharges during F-wave tests were analyzed. After-discharges in the Morvan syndrome group were compared with those in non-Morvan group, and between groups with positive or negative voltage-gated potassium channel (VGKC) complex antibodies.

Results

Twenty-nine patients were included in the study, of which 25 exhibited after-discharges. All after-discharges in Morvan patients occurred following compound muscle action potential (CMAP). In non-Morvan patients, after-discharges occurred following F-wave (32%) and CMAP (47%). The durations of after-discharges following CMAP were significantly prolonged in Morvan (54.2 ± 18.8 ms) compared to non-Morvan patients (34.5 ± 15.0 ms). The majority of antibody-positive patients (18/20) exhibited after-discharges following CMAP, whereas 67% of antibody-negative patients (6/9) showed after-discharges following F-wave.

Discussion

The varying presentations of after-discharges, including their location (after CMAP or F-wave) and the duration of after-discharge can assist in clinically classifying PNHS.

CONFLICT OF INTEREST STATEMENT

The authors declare no conflicts of interest.

Open Research

DATA AVAILABILITY STATEMENT

The data that support the findings of this study are available upon reasonable request from the corresponding author.

Supporting Information

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Volume70, Issue4

October 2024

Pages 800-807

Filename	Description
mus28220-sup-0001-FigureS1.jpgJPEG image, 224 KB	Figure S1: The true disappearance of F-waves in the tibial nerve.
mus28220-sup-0002-TableS1.docxWord 2007 document , 22.5 KB	Table S1: Clinical and laboratory information of patients in case group.

Characteristics of after-discharges following compound muscle action potential or F-wave in primary peripheral nerve hyperexcitability syndrome

Abstract

Introduction/Aims

Methods

Results

Discussion

CONFLICT OF INTEREST STATEMENT

Open Research

DATA AVAILABILITY STATEMENT

Supporting Information

REFERENCES

References

Information

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Characteristics of after-discharges following compound muscle action potential or F-wave in primary peripheral nerve hyperexcitability syndrome

Abstract

Introduction/Aims

Methods

Results

Discussion

CONFLICT OF INTEREST STATEMENT

Open Research

DATA AVAILABILITY STATEMENT

Supporting Information

REFERENCES

References

Related

Information