IVIg for TS-HDS and FGFR-3 antibody–positive small-fiber neuropathy: A fading signal for efficacy?
Corresponding Author
Hans D. Katzberg MD
Division of Neurology, Toronto General Hospital/University Health Network, Toronto, Ontario, Canada
Correspondence
Hans D. Katzberg, Division of Neurology, Toronto General Hospital/University Health Network, 200 Elizabeth Street, 5ES-306, Toronto, ON M5G 2C4, Canada.
Email: [email protected]
Contribution: Conceptualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorCarolina Barnett MD, PhD
Division of Neurology, Toronto General Hospital/University Health Network, Toronto, Ontario, Canada
Contribution: Conceptualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorCorresponding Author
Hans D. Katzberg MD
Division of Neurology, Toronto General Hospital/University Health Network, Toronto, Ontario, Canada
Correspondence
Hans D. Katzberg, Division of Neurology, Toronto General Hospital/University Health Network, 200 Elizabeth Street, 5ES-306, Toronto, ON M5G 2C4, Canada.
Email: [email protected]
Contribution: Conceptualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorCarolina Barnett MD, PhD
Division of Neurology, Toronto General Hospital/University Health Network, Toronto, Ontario, Canada
Contribution: Conceptualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorCONFLICT OF INTEREST
The authors no potential conflict of interest to declare.
REFERENCES
- 1Freeman R, Gewandter JS, Faber CG, et al. Idiopathic distal sensory polyneuropathy: ACTTION diagnostic criteria. Neurology. 2020; 95: 1005-1014.
- 2Devigili G, Rinaldo S, Lombardi R, et al. Diagnostic criteria for small fibre neuropathy in clinical practice and research. Brain. 2019; 142: 3728-3736.
- 3Hoeijmakers JGJ, Merkies ISJ, Faber CG. Small fiber neuropathies: expanding their etiologies. Curr Opin Neurol. 2022; 35: 545-552.
- 4Pindi Sala T, Villedieu M, Damian L, et al. Long-term efficacy of immunoglobulins in small fiber neuropathy related to Sjogren's syndrome. J Neurol. 2020; 267: 3499-3507.
- 5Gavrilova N, Starshinova A, Zinchenko Y, et al. Small fiber neuropathy in sarcoidosis. Pathophysiology. 2021; 28: 544-550.
- 6Liu X, Treister R, Lang M, Oaklander AL. IVIg for apparently autoimmune small fiber polyneuropathy: first analysis of efficacy and safety. Ther Adv Neurol Disord. 2018; 11: 1756285617744484.
- 7Geerts M, de Greef BTA, Sopacua M, et al. Intravenous immunoglobulin therapy in patients with painful idiopathic small fiber neuropathy. Neurology. 2021; 96: e2534-e2545.
- 8Pestronk A, Schmidt R, Choski R, et al. Clinical and laboratory features of neuropathies with serum IgM binding to TS-HDS. Muscle Nerve. 2012; 45: 866-872.
- 9Tholance Y, Moritz CP, Rosier C, et al. Clinical characterisation of sensory neuropathy with anti-FGFR3 autoantibodies. J Neurol Neurosurg Psychiatry. 2020; 91: 49-57.
- 10Trevino JA, Novak P. TS-HDS and FGFR3 antibodies in small fiber neuropathy and dysautonomia. Muscle Nerve. 2021; 64: 70-76.
- 11Levine TD, Kafaie J, Zeidman LA, et al. Cryptogenic small-fiber neuropathies: serum autoantibody binding to trisulfated heparan disaccharide and fibroblast growth factor receptor-3. Muscle Nerve. 2020; 61: 512-515.
- 12Gibbons C, Rajan S, Senechal K, et al. A double-blind placebo-controlled pilot study of immunoglobulin for small fiber neuropathy associated with TS-HDS and FGFR-3 autoantibodies. Muscle Nerve. 2023; 67: 363-370.
- 13Chan ACY, Wong HY, Chong YF, et al. Novel autoantibodies in idiopathic small fiber neuropathy. Ann Neurol. 2022; 91: 66-77.
- 14Song P, Xu X. Reader response: intravenous immunoglobulin therapy in patients with painful idiopathic small fiber neuropathy. Neurology. 2021; 97: 791-792.
- 15Smith AG, Russell J, Feldman EL, et al. Lifestyle intervention for pre-diabetic neuropathy. Diabetes Care. 2006; 29: 1294-1299.
