Investigating the possible association between NLRP3 gene polymorphisms and myasthenia gravis
Elmira Agah MD
Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
NeuroImmunology Research Association (NIRA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Search for more papers by this authorShahriar Nafissi MD
Iranian Center for Neurological Research, Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorFatemeh Saleh MD
Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
NeuroImmunology Research Association (NIRA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Search for more papers by this authorPayam Sarraf MD
Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorAbbas Tafakhori MD
Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
NeuroImmunology Research Association (NIRA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Search for more papers by this authorSeyed Vahid Mousavi MD, MPH
Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
NeuroImmunology Research Association (NIRA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Search for more papers by this authorAmene Saghazadeh MD
Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
Systematic Review and Meta-Analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Search for more papers by this authorMaryam Sadr MSc
Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorFarnaz Sinaei MD
Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorBahareh Mohebbi MSc
Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorMahdi Mahmoudi PhD
Rheumatology Research Center (RRC), Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorHamideh Shadi BS
Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorCorresponding Author
Nima Rezaei MD, PhD
Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Correspondence
Nima Rezaei, Research Center for Immunodeficiencies, Children's Medical Center, Dr. Gharib St, Keshavarz Blvd, Tehran, Iran.
Email: [email protected]
Search for more papers by this authorElmira Agah MD
Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
NeuroImmunology Research Association (NIRA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Search for more papers by this authorShahriar Nafissi MD
Iranian Center for Neurological Research, Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorFatemeh Saleh MD
Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
NeuroImmunology Research Association (NIRA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Search for more papers by this authorPayam Sarraf MD
Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorAbbas Tafakhori MD
Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
NeuroImmunology Research Association (NIRA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Search for more papers by this authorSeyed Vahid Mousavi MD, MPH
Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
NeuroImmunology Research Association (NIRA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Search for more papers by this authorAmene Saghazadeh MD
Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
Systematic Review and Meta-Analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Search for more papers by this authorMaryam Sadr MSc
Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorFarnaz Sinaei MD
Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorBahareh Mohebbi MSc
Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorMahdi Mahmoudi PhD
Rheumatology Research Center (RRC), Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorHamideh Shadi BS
Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorCorresponding Author
Nima Rezaei MD, PhD
Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Correspondence
Nima Rezaei, Research Center for Immunodeficiencies, Children's Medical Center, Dr. Gharib St, Keshavarz Blvd, Tehran, Iran.
Email: [email protected]
Search for more papers by this authorElmira Agah and Shahriar Nafissi contributed equally to this work.
Abstract
Introduction
In this case-control study, we investigated the association between nucleotide oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) single-nucleotide polymorphisms (SNPs) rs10754558, rs3806265, rs4612666, and rs35829419 and myasthenia gravis (MG).
Methods
Samples from MG patients were selected from a previous study conducted in our neuromuscular clinic, which investigated the association between human leukocyte antigen (HLA) class II genes and MG. Genetic data of controls were also available from another study. The NLRP3 SNPs genotyping was performed using the TaqMan method.
Results
A total of 93 blood samples from eligible Iranian patients with MG and 56 samples from healthy controls were obtained. The NLRP3 rs3806265 “C” allele was significantly more frequent in MG patients (P < .001; odd ratio [OR] = 2.33, 95% confidence interval [CI]: 1.4-4.0) than controls. The “CC” genotype of this SNP was found in 18.27% of patients, but none of the controls (P < .001). The distribution of other SNPs was similar between the groups.
Discussion
These preliminary results suggest that there might be some associations between the NLRP3 gene polymorphism and MG.
5 CONFLICT OF INTEREST
None of the authors has any conflict of interest to disclose.
Supporting Information
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| mus27193-sup-0001-supinfo.docxWord 2007 document , 19.5 KB | Appendix S1. Supporting Information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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