Volume 56, Issue 6 pp. E73-E77

Clinical Research

Electrophysiologic features of POEMS syndrome compared with MGUS-related neuropathy

Hyunjin Kim MD,

Hyunjin Kim MD

orcid.org/0000-0003-0264-4531

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Young-Min Lim MD, PhD,

Young-Min Lim MD, PhD

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Joo Yea Jin MD,

Joo Yea Jin MD

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Dok Hyun Yoon MD, PhD,

Dok Hyun Yoon MD, PhD

Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Cheolwon Suh MD, PhD,

Cheolwon Suh MD, PhD

Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Sun-Young Kim MD,

Sun-Young Kim MD

Department of Neurology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea

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Jae-Cheol Jo MD,

Jae-Cheol Jo MD

Department of Hematology and Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea

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Kwang-Kuk Kim MD, PhD,

Corresponding Author

Kwang-Kuk Kim MD, PhD

[email protected]

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Correspondence to: K.-K. Kim; e-mail: [email protected]Search for more papers by this author

Hyunjin Kim MD,

Hyunjin Kim MD

orcid.org/0000-0003-0264-4531

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Search for more papers by this author

Young-Min Lim MD, PhD,

Young-Min Lim MD, PhD

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Search for more papers by this author

Joo Yea Jin MD,

Joo Yea Jin MD

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Search for more papers by this author

Dok Hyun Yoon MD, PhD,

Dok Hyun Yoon MD, PhD

Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Search for more papers by this author

Cheolwon Suh MD, PhD,

Cheolwon Suh MD, PhD

Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Search for more papers by this author

Sun-Young Kim MD,

Sun-Young Kim MD

Department of Neurology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea

Search for more papers by this author

Jae-Cheol Jo MD,

Jae-Cheol Jo MD

Department of Hematology and Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea

Search for more papers by this author

Kwang-Kuk Kim MD, PhD,

Corresponding Author

Kwang-Kuk Kim MD, PhD

[email protected]

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Correspondence to: K.-K. Kim; e-mail: [email protected]Search for more papers by this author

First published: 04 May 2017

https://doi.org/10.1002/mus.25684

Citations: 8

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ABSTRACT

Introduction

Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome and monoclonal gammopathy of undetermined significance (MGUS) are paraproteinemic disorders that can cause demyelinating polyneuropathy. Herein we assessed the findings of nerve conduction studies (NCS) in patients with POEMS syndrome and MGUS-related neuropathy to determine whether the NCS characteristics can help differentiate between these conditions.

Methods

We enrolled 24 POEMS and 37 MGUS-related neuropathy patients. NCS parameters, including compound muscle action potential (CMAP), motor conduction velocity (MCV), and terminal latency index (TLI), were evaluated.

Results

Compared with MGUS-related neuropathy patients, POEMS syndrome patients demonstrated a greater reduction in both the upper and lower limb CMAPs and a greater reduction in the median and ulnar MCVs. The TLIs were significantly higher in POEMS patients.

Discussion

NCS can help distinguish POEMS syndrome from MGUS-related neuropathy. Reduced CMAPs, slow MCVs, and high TLIs are indicative of POEMS syndrome rather than MGUS-related neuropathy. Muscle Nerve 56: E73–E77, 2017

Supporting Information

REFERENCES

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Volume56, Issue6

December 2017

Pages E73-E77

Electrophysiologic features of POEMS syndrome compared with MGUS-related neuropathy

ABSTRACT

Introduction

Methods

Results

Discussion

Supporting Information

REFERENCES

Citing Literature

References

Information

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Electrophysiologic features of POEMS syndrome compared with MGUS-related neuropathy

ABSTRACT

Introduction

Methods

Results

Discussion

Supporting Information

REFERENCES

Citing Literature

References

Related

Information