Peripheral nerve high-resolution ultrasound in diabetes
Ari Breiner MD, MSc
Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Department of Medicine, 5EC-309, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4 Canada
Search for more papers by this authorMohammad Qrimli MD
Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Department of Medicine, 5EC-309, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4 Canada
King Fahad Hospital, Ministry of Health, Madina, Saudi Arabia
Search for more papers by this authorHamid Ebadi MD
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
Search for more papers by this authorMajed Alabdali MD
Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Department of Medicine, 5EC-309, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4 Canada
Department of Neurology, King Fahad University Hospital, University of Dammam, Dammam, Saudi Arabia
Search for more papers by this authorLeif E. Lovblom MSc
Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai Hospital and Lunenfeld-Tanenbaum Research Institute, University of Toronto, Toronto, Ontario, Canada
Search for more papers by this authorAlon Abraham MD
Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Department of Medicine, 5EC-309, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4 Canada
Search for more papers by this authorHana Albulahi MD
Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Department of Medicine, 5EC-309, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4 Canada
Search for more papers by this authorBruce A. Perkins MD, MPH
Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai Hospital and Lunenfeld-Tanenbaum Research Institute, University of Toronto, Toronto, Ontario, Canada
Search for more papers by this authorCorresponding Author
Vera Bril MD
Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Department of Medicine, 5EC-309, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4 Canada
Correspondence to: V. Bril; e-mail: [email protected]Search for more papers by this authorAri Breiner MD, MSc
Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Department of Medicine, 5EC-309, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4 Canada
Search for more papers by this authorMohammad Qrimli MD
Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Department of Medicine, 5EC-309, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4 Canada
King Fahad Hospital, Ministry of Health, Madina, Saudi Arabia
Search for more papers by this authorHamid Ebadi MD
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
Search for more papers by this authorMajed Alabdali MD
Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Department of Medicine, 5EC-309, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4 Canada
Department of Neurology, King Fahad University Hospital, University of Dammam, Dammam, Saudi Arabia
Search for more papers by this authorLeif E. Lovblom MSc
Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai Hospital and Lunenfeld-Tanenbaum Research Institute, University of Toronto, Toronto, Ontario, Canada
Search for more papers by this authorAlon Abraham MD
Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Department of Medicine, 5EC-309, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4 Canada
Search for more papers by this authorHana Albulahi MD
Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Department of Medicine, 5EC-309, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4 Canada
Search for more papers by this authorBruce A. Perkins MD, MPH
Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai Hospital and Lunenfeld-Tanenbaum Research Institute, University of Toronto, Toronto, Ontario, Canada
Search for more papers by this authorCorresponding Author
Vera Bril MD
Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Department of Medicine, 5EC-309, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4 Canada
Correspondence to: V. Bril; e-mail: [email protected]Search for more papers by this authorABSTRACT
Introduction
High-resolution ultrasound (HRU) is used in the diagnosis of peripheral neuropathies. There are conflicting data regarding HRU findings in patients with diabetic sensorimotor polyneuropathy (DSP). Our purpose in this study was to measure nerve cross-sectional areas (CSAs) in patients with diabetes, with and without DSP. Methods: We performed a prospective peripheral nerve HRU study of 100 diabetic subjects, assessed the CSA at predefined sites, and compared the results with those of 100 normal subjects. We evaluated the use of individual CSA values and various summary scores for diagnosis of DSP. Results: Diabetic subjects had higher CSA values than healthy volunteers, and those with DSP had higher CSA values. Three or more enlarged CSA sites predicted DSP with 64% sensitivity and 77% specificity. Conclusions: Peripheral nerves are enlarged diffusely in diabetic patients, including sites not susceptible to bony compression. The number of enlarged CSA values can help predict the presence of DSP. Muscle Nerve, 2016 Muscle Nerve 55: 171–178, 2017
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