Guillain–Barré syndrome during childhood: Particular clinical and electrophysiological features
David Devos MD
Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, F-44093, Nantes cedex, France
Search for more papers by this authorArmelle Magot MD
Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, F-44093, Nantes cedex, France
Search for more papers by this authorJulie Perrier-Boeswillwald MD
Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, F-44093, Nantes cedex, France
Search for more papers by this authorGuillemette Fayet MD, PHD
Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, F-44093, Nantes cedex, France
Search for more papers by this authorLaurene Leclair-Visonneau MD
Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, F-44093, Nantes cedex, France
Search for more papers by this authorYolaine Ollivier MD
Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, F-44093, Nantes cedex, France
Search for more papers by this authorSylvie Nguyen The Tich MD, PHD
Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, F-44093, Nantes cedex, France
Search for more papers by this authorCorresponding Author
Yann Pereon MD, PHD
Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, F-44093, Nantes cedex, France
Correspondence to: Y. Péréon; e-mail: [email protected]Search for more papers by this authorDavid Devos MD
Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, F-44093, Nantes cedex, France
Search for more papers by this authorArmelle Magot MD
Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, F-44093, Nantes cedex, France
Search for more papers by this authorJulie Perrier-Boeswillwald MD
Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, F-44093, Nantes cedex, France
Search for more papers by this authorGuillemette Fayet MD, PHD
Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, F-44093, Nantes cedex, France
Search for more papers by this authorLaurene Leclair-Visonneau MD
Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, F-44093, Nantes cedex, France
Search for more papers by this authorYolaine Ollivier MD
Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, F-44093, Nantes cedex, France
Search for more papers by this authorSylvie Nguyen The Tich MD, PHD
Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, F-44093, Nantes cedex, France
Search for more papers by this authorCorresponding Author
Yann Pereon MD, PHD
Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, F-44093, Nantes cedex, France
Correspondence to: Y. Péréon; e-mail: [email protected]Search for more papers by this authorABSTRACT
Introduction
Guillain–Barré syndrome (GBS) has some specific characteristics in children.
Methods
In this study we reviewed the clinical, laboratory, electrophysiological, and prognosis features of the 19 children diagnosed with GBS at Nantes University Hospital from 2000 to 2011.
Results
Gait disturbance and leg pain were the most frequent presenting symptoms. Electrophysiological examinations revealed significant abnormalities even when performed within the first week after onset. Decreased distal CMAP amplitude was noted in 89% of cases. The pattern indicated an acute inflammatory demyelinating polyneuropathy in 95% of cases and acute motor axonal neuropathy in the remaining 5%. About two-thirds of the children were treated with intravenous immunoglobulin. After >1 year of follow-up, 17 patients had complete recovery.
Conclusion
Gait disorder, leg pain, a high rate of distal conduction block, and a good prognosis are among the main specific features of GBS in childhood. Muscle Nerve, 48: 247–251, 2013
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