Chemical shift separation with controlled aliasing for hyperpolarized 13C metabolic imaging
Corresponding Author
Peter J. Shin
Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA
The UC Berkeley - UCSF Graduate Program in Bioengineering, California, USA
Correspondence to: Peter J. Shin, M.S., Byers Hall Room 102F, 1700 4th Street, University of California at San Francisco, San Francisco, CA 94158. E-mail: [email protected]Search for more papers by this authorPeder E.Z. Larson
Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA
The UC Berkeley - UCSF Graduate Program in Bioengineering, California, USA
Search for more papers by this authorMartin Uecker
Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, California, USA
Search for more papers by this authorGalen D. Reed
Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA
The UC Berkeley - UCSF Graduate Program in Bioengineering, California, USA
Search for more papers by this authorAdam B. Kerr
Magnetic Resonance Systems Research Laboratory, Department of Electrical Engineering, Stanford University, Stanford, California, USA
Search for more papers by this authorJames Tropp
General Electric Healthcare, Fremont, California, USA
Search for more papers by this authorMichael A. Ohliger
Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA
Search for more papers by this authorSarah J. Nelson
Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA
The UC Berkeley - UCSF Graduate Program in Bioengineering, California, USA
Search for more papers by this authorJohn M. Pauly
Magnetic Resonance Systems Research Laboratory, Department of Electrical Engineering, Stanford University, Stanford, California, USA
Search for more papers by this authorMichael Lustig
The UC Berkeley - UCSF Graduate Program in Bioengineering, California, USA
Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, California, USA
Search for more papers by this authorDaniel B. Vigneron
Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA
The UC Berkeley - UCSF Graduate Program in Bioengineering, California, USA
Search for more papers by this authorCorresponding Author
Peter J. Shin
Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA
The UC Berkeley - UCSF Graduate Program in Bioengineering, California, USA
Correspondence to: Peter J. Shin, M.S., Byers Hall Room 102F, 1700 4th Street, University of California at San Francisco, San Francisco, CA 94158. E-mail: [email protected]Search for more papers by this authorPeder E.Z. Larson
Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA
The UC Berkeley - UCSF Graduate Program in Bioengineering, California, USA
Search for more papers by this authorMartin Uecker
Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, California, USA
Search for more papers by this authorGalen D. Reed
Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA
The UC Berkeley - UCSF Graduate Program in Bioengineering, California, USA
Search for more papers by this authorAdam B. Kerr
Magnetic Resonance Systems Research Laboratory, Department of Electrical Engineering, Stanford University, Stanford, California, USA
Search for more papers by this authorJames Tropp
General Electric Healthcare, Fremont, California, USA
Search for more papers by this authorMichael A. Ohliger
Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA
Search for more papers by this authorSarah J. Nelson
Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA
The UC Berkeley - UCSF Graduate Program in Bioengineering, California, USA
Search for more papers by this authorJohn M. Pauly
Magnetic Resonance Systems Research Laboratory, Department of Electrical Engineering, Stanford University, Stanford, California, USA
Search for more papers by this authorMichael Lustig
The UC Berkeley - UCSF Graduate Program in Bioengineering, California, USA
Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, California, USA
Search for more papers by this authorDaniel B. Vigneron
Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA
The UC Berkeley - UCSF Graduate Program in Bioengineering, California, USA
Search for more papers by this authorPresented in part at the 21st Annual Meeting of ISMRM, Salt Lake City, Utah, USA, 2013.
Abstract
Purpose
A chemical shift separation technique for hyperpolarized 13C metabolic imaging with high spatial and temporal resolution was developed. Specifically, a fast three-dimensional pulse sequence and a reconstruction method were implemented to acquire signals from multiple 13C species simultaneously with subsequent separation into individual images.
Theory and Methods
A stack of flyback echo-planar imaging readouts and a set of multiband excitation radiofrequency pulses were designed to spatially modulate aliasing patterns of the acquired metabolite images, which translated the chemical shift separation problem into parallel imaging reconstruction problem. An eight-channel coil array was used for data acquisition and a parallel imaging method based on nonlinear inversion was developed to separate the aliased images.
Results
Simultaneous acquisitions of pyruvate and lactate in a phantom study and in vivo rat experiments were performed. The results demonstrated successful separation of the metabolite distributions into individual images having high spatial resolution.
Conclusion
This method demonstrated the ability to provide accelerated metabolite imaging in hyperpolarized 13C MR using multichannel coils, tailored readout, and specialized RF pulses. Magn Reson Med 74:978–989, 2015. © 2014 Wiley Periodicals, Inc.
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