Full Paper

Three-dimensional J-resolved H-1 magnetic resonance spectroscopic imaging of volunteers and patients with brain tumors at 3T^†

Corresponding Author

Yan Li

[email protected]

University of California, San Francisco/University of California, Berkeley (UCSF/UCB) Joint Graduate Group in Bioengineering, San Francisco, California, USA

Surbeck Laboratory of Advanced Imaging, Department of Radiology, University of California, San Francisco, San Francisco, California, USA

UCSF Radiology Box 2532, Byers Hall, 1700 4th Street, San Francisco, CA 94143-2532===Search for more papers by this author

Albert P. Chen,

Albert P. Chen

Surbeck Laboratory of Advanced Imaging, Department of Radiology, University of California, San Francisco, San Francisco, California, USA

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Jason C. Crane,

Jason C. Crane

Surbeck Laboratory of Advanced Imaging, Department of Radiology, University of California, San Francisco, San Francisco, California, USA

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Susan M. Chang,

Susan M. Chang

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA

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Daniel B. Vigneron,

Daniel B. Vigneron

University of California, San Francisco/University of California, Berkeley (UCSF/UCB) Joint Graduate Group in Bioengineering, San Francisco, California, USA

Surbeck Laboratory of Advanced Imaging, Department of Radiology, University of California, San Francisco, San Francisco, California, USA

Program in Bioengineering, University of California, San Francisco, San Francisco, California, USA

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Sarah J. Nelson,

Sarah J. Nelson

University of California, San Francisco/University of California, Berkeley (UCSF/UCB) Joint Graduate Group in Bioengineering, San Francisco, California, USA

Surbeck Laboratory of Advanced Imaging, Department of Radiology, University of California, San Francisco, San Francisco, California, USA

Program in Bioengineering, University of California, San Francisco, San Francisco, California, USA

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Yan Li,

Corresponding Author

Yan Li

[email protected]

University of California, San Francisco/University of California, Berkeley (UCSF/UCB) Joint Graduate Group in Bioengineering, San Francisco, California, USA

Surbeck Laboratory of Advanced Imaging, Department of Radiology, University of California, San Francisco, San Francisco, California, USA

UCSF Radiology Box 2532, Byers Hall, 1700 4th Street, San Francisco, CA 94143-2532===Search for more papers by this author

Albert P. Chen,

Albert P. Chen

Surbeck Laboratory of Advanced Imaging, Department of Radiology, University of California, San Francisco, San Francisco, California, USA

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Jason C. Crane,

Jason C. Crane

Surbeck Laboratory of Advanced Imaging, Department of Radiology, University of California, San Francisco, San Francisco, California, USA

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Susan M. Chang,

Susan M. Chang

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA

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Daniel B. Vigneron,

Daniel B. Vigneron

University of California, San Francisco/University of California, Berkeley (UCSF/UCB) Joint Graduate Group in Bioengineering, San Francisco, California, USA

Surbeck Laboratory of Advanced Imaging, Department of Radiology, University of California, San Francisco, San Francisco, California, USA

Program in Bioengineering, University of California, San Francisco, San Francisco, California, USA

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Sarah J. Nelson,

Sarah J. Nelson

University of California, San Francisco/University of California, Berkeley (UCSF/UCB) Joint Graduate Group in Bioengineering, San Francisco, California, USA

Surbeck Laboratory of Advanced Imaging, Department of Radiology, University of California, San Francisco, San Francisco, California, USA

Program in Bioengineering, University of California, San Francisco, San Francisco, California, USA

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First published: 29 October 2007

https://doi.org/10.1002/mrm.21415

Citations: 19

^†

This work was presented in part at the 15th Annual Meeting of ISMRM, Berlin, Germany, 2007

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Abstract

A method that combines two-dimensional (2D) J-resolved spectroscopy with three spatial dimension magnetic resonance spectroscopic imaging (MRSI) is introduced to measure J-coupled metabolites of glutamate (Glu), glutamine (Gln), myo-Inositol (mI), and lactate (Lac) in the brain and to simultaneously obtain T₂ values of choline (Cho), creatine (Cr), and N-acetyl aspartate (NAA). Relatively few points in the t₁ dimension (six echo times) and a flyback echo-planar trajectory were incorporated in the acquisition to speed up the total acquisition time so that it was within a clinically feasible range (23 min). Data obtained using GAMMA software simulations and from phantoms have shown that the ⁴CH₂ resonances of Glu can be separated from Gln at 2.35 ppm in TE-averaged spectra. Results from phantoms, six normal volunteers, and four patients demonstrated good signal-to-noise ratio (SNR). The J cross-peaks from the methyl group of Lac were visualized in the 2D spectra from the phantom and the glioma patient, and could be quantified from the spectra at J = ±4.17 Hz. This technique also enables the evaluation of the changes in metabolite T₂. Compared with the values in normal white matter, the T₂ values of Cho and Cr were statistically significantly increased in regions of glioma. Magn Reson Med 58:886–892, 2007. © 2007 Wiley-Liss, Inc.

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Volume58, Issue5

November 2007

Pages 886-892

Three-dimensional J-resolved H-1 magnetic resonance spectroscopic imaging of volunteers and patients with brain tumors at 3T^†

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Three-dimensional J-resolved H-1 magnetic resonance spectroscopic imaging of volunteers and patients with brain tumors at 3T†

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Three-dimensional J-resolved H-1 magnetic resonance spectroscopic imaging of volunteers and patients with brain tumors at 3T^†