High-resolution isotropic 3D diffusion tensor imaging of the human brain
Corresponding Author
Xavier Golay
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, 707 N. Broadway, Baltimore, MD 21205===Search for more papers by this authorHangyi Jiang
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland
Search for more papers by this authorPeter C.M. van Zijl
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland
Search for more papers by this authorSusumu Mori
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland
Search for more papers by this authorCorresponding Author
Xavier Golay
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, 707 N. Broadway, Baltimore, MD 21205===Search for more papers by this authorHangyi Jiang
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland
Search for more papers by this authorPeter C.M. van Zijl
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland
Search for more papers by this authorSusumu Mori
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland
Search for more papers by this authorAbstract
High-resolution cardiac-gated 3D diffusion tensor imaging (3D-DTI) is demonstrated in vivo for several areas of the human brain. Anatomical mapping of subcortical white matter (WM), as well as definition and identification of major WM bundles from the brainstem were performed in humans for the first time using this technique. Improved intrinsic signal-to-noise ratio (SNR) and relatively reduced sensitivity to physiological motion (e.g., brain pulsations) with respect to cardiac-gated multislice acquisition are demonstrated. The advantages and weaknesses of this approach are discussed. Magn Reson Med 47:837–843, 2002. © 2002 Wiley-Liss, Inc.
REFERENCES
- 1 Moseley ME, Cohen Y, Mintorovitch J, Chileuitt L, Shimizu H, Kucharczyk J, Wendland MV, Weinstein PR. Early detection of regional cerebral ischemia in cats: comparison of diffusion- and T2-weighted MRI and spectroscopy. Magn Reson Med 1990; 14: 330–346.
- 2 Basser PJ, Mattiello J, Le Bihan D. MR diffusion tensor spectroscopy and imaging. Biophys J 1994; 66: 259–267.
- 3 Pierpaoli C, Jezzard P, Basser PJ, Barnett A, Di Chiro G. Diffusion tensor MR imaging of human brain. Radiology 1996; 201: 637–648.
- 4 Mori S, Crain BJ, Chacko VP, van Zijl PCM. Three dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Ann Neurol 1999; 45: 265–269.
- 5
Xue R,
van Zijl PCM,
Crain BJ,
Solaiyappan M,
Mori S.
In vivo three-dimensional reconstruction of rat brain axonal projections by diffusion tensor imaging.
Magn Reson Med
1999;
42:
1123–1127.
10.1002/(SICI)1522-2594(199912)42:6<1123::AID-MRM17>3.0.CO;2-H CAS PubMed Web of Science® Google Scholar
- 6
Jones DK,
Simmons A,
Williams SC,
Horsfield MA.
Non-invasive assessment of axonal fiber connectivity in the human brain via diffusion tensor MRI.
Magn Reson Med
1999;
42:
37–41.
10.1002/(SICI)1522-2594(199907)42:1<37::AID-MRM7>3.0.CO;2-O CAS PubMed Web of Science® Google Scholar
- 7 Conturo TE, Lori NF, Cull TS, Akbudak E, Snyder AZ, Shimony JS, McKinstry RC, Burton H, Raichle ME. Tracking neuronal fiber pathways in the living human brain. Proc Natl Acad Sci USA 1999; 96: 10422–10427.
- 8 Mori S, Kaufmann WK, Pearlson GD, Crain BJ, Stieltjes B, Solaiyappan M, van Zijl PCM. In vivo visualization of human neural pathways by MRI. Ann Neurol 2000; 47: 412–414.
- 9 Basser PJ, Pajevic S, Pierpaoli C, Duda J, Aldroubi A. In vitro fiber tractography using DT-MRI data. Magn Reson Med 2000; 44: 625–632.
- 10 Poupon C, Clark CA, Frouin V, Regis J, Bloch L, Le Bihan D, Mangin JF. Regularization of diffusion-based direction maps for the tracking of brain white matter fascicules. NeuroImage 2000; 12: 184–195.
- 11 Stieltjes B, Kaufmann WE, van Zijl PCM, Fredericksen K, Pearlson GD, Mori S. Diffusion tensor imaging and axonal tracking in the human brainstem. NeuroImage 2001; 14: 723–735.
- 12 Tuch DS, Belliveau JW, Wedeen V. A path integral approach to white matter tractography. In: Proceedings of the 8th Annual Meeting of ISMRM, Denver, 2000. p 791.
- 13 Parker GJ. Tracing fiber tracts using fast marching. In: Proceedings of the 8th Annual Meeting of ISMRM, Denver, 2000. p 85.
- 14 Peled S, Greenspan H, Oz G, Yeshurun Y, Kiryati N. High resolution MRI from 2D and 3D superresolution applied to single-shot images. In: Proceedings of the 9th Annual Meeting of ISMRM, Glasgow, Scotland, 2001. p 165.
- 15 Peled S, Yeshurun Y. Superresolution in MRI: application to human white matter fiber tract visualization by diffusion tensor imaging. Magn Reson Med 2001; 45: 29–35.
- 16 Xue R, Sawada M, Goto S, Hurn PD, Traystman RJ, van Zijl PC, Mori S. Rapid three-dimensional diffusion MRI facilitates the study of acute stroke in mice. Magn Reson Med 2001; 46: 183–188.
- 17 Jiang H, Golay X, van Zijl PCM, Mori S. Origin and minimization of residual motion-related artifacts in navigator-corrected segmented diffusion-weighted EPI of the human brain. Magn Reson Med 2002; 47: 818–822.
- 18
Pajevic S,
Pierpaoli C.
Color schemes to represent the orientation of anisotropic tissues from diffusion tensor data: application to white matter fiber tract mapping in the human brain.
Magn Reson Med
1999;
42:
526–540.
10.1002/(SICI)1522-2594(199909)42:3<526::AID-MRM15>3.0.CO;2-J CAS PubMed Web of Science® Google Scholar
- 19 Mori S, Kaufmann WE, Davatzikos C, Stieltjes B, Amodei L, Fredericksen K, Pearlson GD, Melhem ER, Solaiyappan M, Raymond GV, Moser HW, van Zijl PCM. Imaging cortical association tracts in human brain. Magn Reson Med 2002; 47: 215–223.
- 20
Pruessmann KP,
Weiger M,
Scheidegger MB,
Boesiger P.
SENSE: sensitivity encoding for fast MRI.
Magn Reson Med
1999;
42:
952–962.
10.1002/(SICI)1522-2594(199911)42:5<952::AID-MRM16>3.0.CO;2-S CAS PubMed Web of Science® Google Scholar
- 21 Bammer R, Keeling SL, Augustin M, Pruessmann KP, Wolf R, Stollberger R, Hartung HP, Fazekas F. Improved diffusion-weighted single-shot echo-planar imaging (EPI) in stroke using sensitivity encoding (SENSE). Magn Reson Med 2001; 46: 548–554.
- 22 Golay X, Pruessmann KP, Weiger M, Crelier GR, Folkers PJ, Kollias SS, Boesiger P. PRESTO-SENSE: an ultrafast whole-brain fMRI technique. Magn Reson Med 2000; 43: 779–786.
- 23 Nguyen Q, Clemence M, Thornton J, Ordidge RJ. Isotropic diffusion-weighted multishot imaging using automatic reacquisition. In: Proceedings of the 7th Annual Meeting of ISMRM, Philadelphia, 1999. p 165.
- 24 Williams TH, Gluhbegovic N, Jew JY. The human brain: dissections of the real brain. Virtual Hospital, University of Iowa, 1997; http://www.vh.org/Providers/Textbooks/BrainAnatomy/BrainAnatomy.html
