Preparation and Bioimaging Applications of AIE Dye Cross-linked Luminescent Polymeric Nanoparticles
Meiying Liu
Department of Chemistry/Institute of Polymers, Nanchang University, 999 Xuefu Avenue, Nanchang, 330031 PR China
Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids, Laboratory of New Materials, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190 PR China
Search for more papers by this authorXiqi Zhang
Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084 PR China
Search for more papers by this authorBin Yang
Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084 PR China
Search for more papers by this authorFengjie Deng
Department of Chemistry/Institute of Polymers, Nanchang University, 999 Xuefu Avenue, Nanchang, 330031 PR China
Search for more papers by this authorYang Yang
Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084 PR China
Search for more papers by this authorZhen Li
Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084 PR China
Search for more papers by this authorCorresponding Author
Xiaoyong Zhang
Department of Chemistry/Institute of Polymers, Nanchang University, 999 Xuefu Avenue, Nanchang, 330031 PR China
Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084 PR China
Search for more papers by this authorCorresponding Author
Yen Wei
Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084 PR China
Search for more papers by this authorMeiying Liu
Department of Chemistry/Institute of Polymers, Nanchang University, 999 Xuefu Avenue, Nanchang, 330031 PR China
Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids, Laboratory of New Materials, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190 PR China
Search for more papers by this authorXiqi Zhang
Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084 PR China
Search for more papers by this authorBin Yang
Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084 PR China
Search for more papers by this authorFengjie Deng
Department of Chemistry/Institute of Polymers, Nanchang University, 999 Xuefu Avenue, Nanchang, 330031 PR China
Search for more papers by this authorYang Yang
Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084 PR China
Search for more papers by this authorZhen Li
Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084 PR China
Search for more papers by this authorCorresponding Author
Xiaoyong Zhang
Department of Chemistry/Institute of Polymers, Nanchang University, 999 Xuefu Avenue, Nanchang, 330031 PR China
Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084 PR China
Search for more papers by this authorCorresponding Author
Yen Wei
Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084 PR China
Search for more papers by this authorAbstract
With the ever increasing interest in biomedical applications of luminescent probes, the development of novel luminescent nanoparticles which showed high water dispersibility, strong luminescence and excellent biocompatibility has been extensively pursued. In this work, cross-linked luminescent polymeric nanoparticles based on aggregation induced emission (AIE) dyes were fabricated through combination of free radical polymerization and ring-opening reaction using AIE dye as the fluorogen and linker simultaneously. Our results demonstrated that these AIE dye based cross-inked polymeric nanoparticles showed high water dispersibility, remarkable luminescent properties and excellent biocompatibility, is highly potential for biomedical applications.
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