Telechelic Poly(2-oxazoline)s with a Biocidal and a Polymerizable Terminal as Collagenase Inhibiting Additive for Long-Term Active Antimicrobial Dental Materials
Christoph P. Fik
Chair of Biomaterials and Polymer Science, Department of Biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany
Search for more papers by this authorStefan Konieczny
Chair of Biomaterials and Polymer Science, Department of Biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany
Search for more papers by this authorDavid H. Pashley
Department of Oral Biology, College of Dental Medicine, Georgia Health Sciences University, Augusta, GA 30912, USA
Search for more papers by this authorChristian J. Waschinski
Freiburg Materials Research Center, University of Freiburg, Stefan-Meier-Str., 79104 Freiburg, Germany
Search for more papers by this authorReinhild S. Ladisch
Chair of Biomaterials and Polymer Science, Department of Biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany
Search for more papers by this authorUlrich Salz
Ivoclar Vivadent AG, Bendererstr. 2, 9494 Schaan, Liechtenstein
Search for more papers by this authorThorsten Bock
Ivoclar Vivadent AG, Bendererstr. 2, 9494 Schaan, Liechtenstein
Search for more papers by this authorCorresponding Author
Joerg C. Tiller
Chair of Biomaterials and Polymer Science, Department of Biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany
Search for more papers by this authorChristoph P. Fik
Chair of Biomaterials and Polymer Science, Department of Biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany
Search for more papers by this authorStefan Konieczny
Chair of Biomaterials and Polymer Science, Department of Biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany
Search for more papers by this authorDavid H. Pashley
Department of Oral Biology, College of Dental Medicine, Georgia Health Sciences University, Augusta, GA 30912, USA
Search for more papers by this authorChristian J. Waschinski
Freiburg Materials Research Center, University of Freiburg, Stefan-Meier-Str., 79104 Freiburg, Germany
Search for more papers by this authorReinhild S. Ladisch
Chair of Biomaterials and Polymer Science, Department of Biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany
Search for more papers by this authorUlrich Salz
Ivoclar Vivadent AG, Bendererstr. 2, 9494 Schaan, Liechtenstein
Search for more papers by this authorThorsten Bock
Ivoclar Vivadent AG, Bendererstr. 2, 9494 Schaan, Liechtenstein
Search for more papers by this authorCorresponding Author
Joerg C. Tiller
Chair of Biomaterials and Polymer Science, Department of Biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany
Search for more papers by this authorAbstract
Dental repair materials face the problem that the dentin below the composite fillings is actively decomposed by secondary caries and extracellular proteases. To address this problem, poly(2-methyloxazoline) with a biocidal and a polymerizable terminal was explored as additive for a commercial dental adhesive. 2.5 wt% of the additive rendered the adhesive contact-active against Streptococcus mutans and washing with water for 101 d did not diminish this effect. The adhesive with 5 wt% additive kills S. mutans cells in the tubuli of bovine dentin. Further, the additive inhibits bacterial collagenase at 0.5 wt% and reduces activity of MMP-9. Human MMPs bound to dentin are inhibited by 96% in a medium with 5 wt% additive. Moreover, no adverse effect on the enamel/dentine shear bond strength was detected.
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