Volume 129, Issue 5 pp. 1025-1029

Allergy/Rhinology

A Population-Based Analysis of Nodal Metastases in Esthesioneuroblastomas of the Sinonasal Tract

Edward C. Kuan MD, MBA,

Edward C. Kuan MD, MBA

orcid.org/0000-0003-3475-0718

Department of Otolaryngology–Head and Neck Surgery, University of California, Irvine Medical Center, Orange

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Hassan B. Nasser MD,

Hassan B. Nasser MD

Department of Head and Neck Surgery, David Geffen School of Medicine at the University of California, Los Angeles (UCLA) Medical Center, Los Angeles, California

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Ryan M. Carey MD,

Ryan M. Carey MD

orcid.org/0000-0002-0186-2265

Department of Otorhinolaryngology–Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.

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Alan D. Workman MTR,

Alan D. Workman MTR

orcid.org/0000-0001-9573-6472

Department of Otorhinolaryngology–Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.

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Jose E. Alonso MD,

Jose E. Alonso MD

orcid.org/0000-0003-3602-7347

Department of Head and Neck Surgery, David Geffen School of Medicine at the University of California, Los Angeles (UCLA) Medical Center, Los Angeles, California

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Marilene B. Wang MD,

Marilene B. Wang MD

orcid.org/0000-0002-2799-6325

Department of Head and Neck Surgery, David Geffen School of Medicine at the University of California, Los Angeles (UCLA) Medical Center, Los Angeles, California

Jonsson Comprehensive Cancer Center, Los Angeles, California

Head and Neck Cancer Program, UCLA Medical Center, Los Angeles, California

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Maie A. St. John MD, PhD,

Maie A. St. John MD, PhD

Department of Head and Neck Surgery, David Geffen School of Medicine at the University of California, Los Angeles (UCLA) Medical Center, Los Angeles, California

Jonsson Comprehensive Cancer Center, Los Angeles, California

Head and Neck Cancer Program, UCLA Medical Center, Los Angeles, California

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James N. Palmer MD,

James N. Palmer MD

Head and Neck Cancer Program, UCLA Medical Center, Los Angeles, California

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Nithin D. Adappa MD,

Nithin D. Adappa MD

Head and Neck Cancer Program, UCLA Medical Center, Los Angeles, California

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Bobby A. Tajudeen MD,

Corresponding Author

Bobby A. Tajudeen MD

[email protected]

Department of Otolaryngology–Head and Neck Surgery, Rush University Medical Center, Chicago, Illinois, U.S.A.

Send correspondence to Bobby A. Tajudeen, MD, Department of Otolaryngology–Head & Neck Surgery Rush University Medical Center, 1611 W. Harrison St, St. 550, Chicago, IL 60612. E-mail: [email protected].Search for more papers by this author

Edward C. Kuan MD, MBA,

Edward C. Kuan MD, MBA

orcid.org/0000-0003-3475-0718

Department of Otolaryngology–Head and Neck Surgery, University of California, Irvine Medical Center, Orange

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Hassan B. Nasser MD,

Hassan B. Nasser MD

Department of Head and Neck Surgery, David Geffen School of Medicine at the University of California, Los Angeles (UCLA) Medical Center, Los Angeles, California

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Ryan M. Carey MD,

Ryan M. Carey MD

orcid.org/0000-0002-0186-2265

Department of Otorhinolaryngology–Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.

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Alan D. Workman MTR,

Alan D. Workman MTR

orcid.org/0000-0001-9573-6472

Department of Otorhinolaryngology–Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.

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Jose E. Alonso MD,

Jose E. Alonso MD

orcid.org/0000-0003-3602-7347

Department of Head and Neck Surgery, David Geffen School of Medicine at the University of California, Los Angeles (UCLA) Medical Center, Los Angeles, California

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Marilene B. Wang MD,

Marilene B. Wang MD

orcid.org/0000-0002-2799-6325

Department of Head and Neck Surgery, David Geffen School of Medicine at the University of California, Los Angeles (UCLA) Medical Center, Los Angeles, California

Jonsson Comprehensive Cancer Center, Los Angeles, California

Head and Neck Cancer Program, UCLA Medical Center, Los Angeles, California

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Maie A. St. John MD, PhD,

Maie A. St. John MD, PhD

Department of Head and Neck Surgery, David Geffen School of Medicine at the University of California, Los Angeles (UCLA) Medical Center, Los Angeles, California

Jonsson Comprehensive Cancer Center, Los Angeles, California

Head and Neck Cancer Program, UCLA Medical Center, Los Angeles, California

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James N. Palmer MD,

James N. Palmer MD

Head and Neck Cancer Program, UCLA Medical Center, Los Angeles, California

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Nithin D. Adappa MD,

Nithin D. Adappa MD

Head and Neck Cancer Program, UCLA Medical Center, Los Angeles, California

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Bobby A. Tajudeen MD,

Corresponding Author

Bobby A. Tajudeen MD

[email protected]

Department of Otolaryngology–Head and Neck Surgery, Rush University Medical Center, Chicago, Illinois, U.S.A.

First published: 08 September 2018

https://doi.org/10.1002/lary.27301

Citations: 32

Presented as a poster at the 2017 American Rhinologic Society meeting during the Combined Otolaryngological Spring Meeting, San Diego, California, U.S.A.

The authors have no funding, financial relationships, or conflicts of interest to disclose.

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Abstract

Objective

Esthesioneuroblastoma is an uncommon malignancy of the sinonasal tract arising from the olfactory epithelium. Surgical management of the primary site, often via an endoscopic approach, with or without adjuvant radiation, is often curative. There is growing but ultimately limited data regarding management of the neck and the risk of nodal metastases. In this study, we examine the incidence and patterns of esthesioneuroblastoma-related cervical nodal metastases using the Surveillance, Epidemiology, and End Results (SEER) database.

Methods

The SEER registry was queried for all patients with esthesioneuroblastomas diagnosed between 1973 and 2012. Patient data was then analyzed with respect to age, sex, race, modified Kadish stage, grade, survival functions, and nodal disease including specific nodal basins.

Results

Three hundred and eighty-one cases of esthesioneuroblastoma with information on nodal metastases were identified. The overall cervical nodal metastasis rate was 8.7%. Level II metastases were most common (6.6%). A total of 4.5% of cases presented with multiple positive nodal basins. Male sex (P = 0.009) and higher tumor grade (P = 0.009) correlated with the presence of level II metastases. There was no association of primary tumor site to the presence of nodal metastases (P > 0.05). The presence of nodal disease significantly predicted poorer overall (P = 0.001) and disease-specific survival (P = 0.017).

Conclusion

The incidence of nodal metastases in esthesioneuroblastoma at diagnosis is rare, and elective management of the neck remains controversial. Primary tumor site does not appear to predict metastases at specific nodal basins. Higher tumor grade may be a harbinger of eventual nodal metastases.

Level of Evidence

NA Laryngoscope, 129:1025–1029, 2019

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Citing Literature

Volume129, Issue5

May 2019

Pages 1025-1029

A Population-Based Analysis of Nodal Metastases in Esthesioneuroblastomas of the Sinonasal Tract

Abstract

Objective

Methods

Results

Conclusion

Level of Evidence

BIBLIOGRAPHY

Citing Literature

References

Information

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A Population-Based Analysis of Nodal Metastases in Esthesioneuroblastomas of the Sinonasal Tract

Abstract

Objective

Methods

Results

Conclusion

Level of Evidence

BIBLIOGRAPHY

Citing Literature

References

Related

Information