Pediatrics

High-frequency sensorineural hearing loss in children

Kaalan Johnson MD

Department of Otolaryngology–Head and Neck Surgery, University of Washington School of Medicine and Seattle Children's Hospital, Seattle, Washington, U.S.A

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Meredith Tabangin MPH,

Meredith Tabangin MPH

Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A

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Jareen Meinzen-Derr PhD,

Jareen Meinzen-Derr PhD

Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A

Ear and Hearing Center, Division of Pediatric Otolaryngology–Head and Neck Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A

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Aliza P. Cohen MA,

Aliza P. Cohen MA

Ear and Hearing Center, Division of Pediatric Otolaryngology–Head and Neck Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A

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John H. Greinwald MD,

Corresponding Author

John H. Greinwald MD

Ear and Hearing Center, Division of Pediatric Otolaryngology–Head and Neck Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A

Department of Otolaryngology–Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A

Send correspondence to John H. Greinwald, MD, Division of Pediatric Otolaryngology–Head and Neck Surgery, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., MLC 2018, Cincinnati, OH 45229-3039. E-mail: [email protected]Search for more papers by this author

Kaalan Johnson MD,

Kaalan Johnson MD

Department of Otolaryngology–Head and Neck Surgery, University of Washington School of Medicine and Seattle Children's Hospital, Seattle, Washington, U.S.A

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Meredith Tabangin MPH,

Meredith Tabangin MPH

Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A

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Jareen Meinzen-Derr PhD,

Jareen Meinzen-Derr PhD

Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A

Ear and Hearing Center, Division of Pediatric Otolaryngology–Head and Neck Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A

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Aliza P. Cohen MA,

Aliza P. Cohen MA

Ear and Hearing Center, Division of Pediatric Otolaryngology–Head and Neck Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A

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John H. Greinwald MD,

Corresponding Author

John H. Greinwald MD

Ear and Hearing Center, Division of Pediatric Otolaryngology–Head and Neck Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A

Department of Otolaryngology–Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A

First published: 12 August 2015

https://doi.org/10.1002/lary.25544

Citations: 5

Presented at the Annual Meeting of the American Society of Pediatric Otolaryngology, Las Vegas, Nevada, U.S.A., May 1, 2010.

The authors have no funding, financial relationships, or conflicts of interest to disclose.

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Abstract

Objectives/Hypothesis

Determine the prevalence of high-frequency sensorineural hearing loss (HFSNHL) in our hearing loss population and a diagnostic algorithm for these patients.

Study Design

Retrospective case series.

Methods

We identified patients diagnosed with sensorineural hearing loss (SNHL) at our pediatric tertiary care institution from 1981 to 2010. Based on audiometric profiles, these patients were subdivided into those with a flat SNHL configuration and those with HFSNHL. Imaging and genetic testing data and data regarding age at diagnosis, laterality, and risk factors were obtained for both groups. Comparisons were then made between the two groups.

Results

Of 2,867 patients included in the study, 7.6% had HFSNHL. Age at diagnosis was significantly higher in HFSNHL patients (8.3 years vs. 6.1 years; P < .0001). These patients also had a significantly higher proportion of unilateral versus bilateral loss (49.1% vs. 26.1%; P < .0001); unilateral losses were also less severe. Genetic testing showed no significant difference between groups in the proportion of patients tested or in those who tested positive. Similarly, imaging data revealed no difference in the proportion of patients tested in the two groups; however, overall diagnostic yield was significantly higher in flat SNHL patients (29.5% vs.17.3; P = .02).

Conclusions

The positive predictive value of simple genetic testing is similar to that of imaging studies. However, given cost differences between genetic testing and imaging, it is prudent to perform genetic testing as the initial diagnostic test. Determination of whether high-throughput, multigene diagnostic platforms offer an added benefit in the evaluation of children requires further study.

Level of Evidence

4. Laryngoscope, 126:1236–1240, 2016

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Citing Literature

Volume126, Issue5

May 2016

Pages 1236-1240

High-frequency sensorineural hearing loss in children

Abstract

Objectives/Hypothesis

Study Design

Methods

Results

Conclusions

Level of Evidence

BIBLIOGRAPHY

Citing Literature

References

Information

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High-frequency sensorineural hearing loss in children

Abstract

Objectives/Hypothesis

Study Design

Methods

Results

Conclusions

Level of Evidence

BIBLIOGRAPHY

Citing Literature

References

Related

Information