Simultaneous integrated boost–intensity-modulated radiotherapy in head and neck cancer
Corresponding Author
Davide Franceschini MD
Department of Radiation Oncology, IFCA, University of Florence, Florence, Italy
Send correspondence to Davide Franceschini, MD, Department of Radiotherapy, University of Florence, Largo G.A. Brambilla 3, 50134 Florence, Italy. E-mail: [email protected]Search for more papers by this authorFabiola Paiar MD
Department of Radiation Oncology, IFCA, University of Florence, Florence, Italy
Search for more papers by this authorIcro Meattini MD
Department of Radiation Oncology, IFCA, University of Florence, Florence, Italy
Search for more papers by this authorBenedetta Agresti MD
Department of Radiation Oncology, IFCA, University of Florence, Florence, Italy
Search for more papers by this authorEleonora Monteleone Pasquetti MD
Department of Radiation Oncology, IFCA, University of Florence, Florence, Italy
Search for more papers by this authorDaniela Greto MD
Department of Radiation Oncology, IFCA, University of Florence, Florence, Italy
Search for more papers by this authorPierluigi Bonomo MD
Radiotherapy Unit, IFCA, University of Florence, Florence, Italy
Search for more papers by this authorLivia Marrazzo PhD
Department of Medical Physics, IFCA, University of Florence, Florence, Italy
Search for more papers by this authorMarta Casati PhD
Department of Medical Physics, IFCA, University of Florence, Florence, Italy
Search for more papers by this authorLorenzo Livi MD
Radiotherapy Unit, IFCA, University of Florence, Florence, Italy
Search for more papers by this authorGiampaolo Biti MD
Department of Radiation Oncology, IFCA, University of Florence, Florence, Italy
Search for more papers by this authorCorresponding Author
Davide Franceschini MD
Department of Radiation Oncology, IFCA, University of Florence, Florence, Italy
Send correspondence to Davide Franceschini, MD, Department of Radiotherapy, University of Florence, Largo G.A. Brambilla 3, 50134 Florence, Italy. E-mail: [email protected]Search for more papers by this authorFabiola Paiar MD
Department of Radiation Oncology, IFCA, University of Florence, Florence, Italy
Search for more papers by this authorIcro Meattini MD
Department of Radiation Oncology, IFCA, University of Florence, Florence, Italy
Search for more papers by this authorBenedetta Agresti MD
Department of Radiation Oncology, IFCA, University of Florence, Florence, Italy
Search for more papers by this authorEleonora Monteleone Pasquetti MD
Department of Radiation Oncology, IFCA, University of Florence, Florence, Italy
Search for more papers by this authorDaniela Greto MD
Department of Radiation Oncology, IFCA, University of Florence, Florence, Italy
Search for more papers by this authorPierluigi Bonomo MD
Radiotherapy Unit, IFCA, University of Florence, Florence, Italy
Search for more papers by this authorLivia Marrazzo PhD
Department of Medical Physics, IFCA, University of Florence, Florence, Italy
Search for more papers by this authorMarta Casati PhD
Department of Medical Physics, IFCA, University of Florence, Florence, Italy
Search for more papers by this authorLorenzo Livi MD
Radiotherapy Unit, IFCA, University of Florence, Florence, Italy
Search for more papers by this authorGiampaolo Biti MD
Department of Radiation Oncology, IFCA, University of Florence, Florence, Italy
Search for more papers by this authorThe authors have no funding, financial relationships, or conflicts of interest to disclose.
Abstract
Objectives/Hypothesis
To review toxicity and outcomes in patients with head and neck cancer treated with simultaneous integrated boost–intensity-modulated radiotherapy (SIB-IMRT).
Study Design
Review of experience with the SIB-IMRT technique.
Methods
Fifty patients were treated with the SIB-IMRT technique. Two possible schedules of radiation therapy (RT) were used: SIB 70 (70/60/54 in 33 fractions) and SIB 66 (66/60/54 in 33 fractions). Forty-one patients also received chemotherapy.
Results
All but two patients completed treatment as prescribed. No G4 acute toxicity has been reported in our series. We did not observe any G3 to G4 chronic toxicity, apart from one case of cutaneous necrosis. After a median follow-up of 23.3 months (range, 1–60 months), 41 patients (82%) were alive and negative for disease, and one patient (2%) was alive with distant metastases. Eight patients (16%) died, seven because of progressive disease and one for other causes.
Conclusions
SIB-IMRT is a highly effective and safe technique of RT in the treatment of head and neck cancer.
Level of Evidence
4 Laryngoscope, 123:E97–E103, 2013
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