Challenges and Considerations When Using Shear Wave Elastography to Evaluate the Transplanted Kidney, With Pictorial Review
Heather Early MD
Department of Radiology, University of California Davis Medical Center, Sacramento, California, USA
Search for more papers by this authorJorge Aguilera BS
Department of Radiology, University of California Davis Medical Center, Sacramento, California, USA
Search for more papers by this authorEllen Cheang MD
Department of Radiology, University of California Davis Medical Center, Sacramento, California, USA
Search for more papers by this authorCorresponding Author
John McGahan MD
Department of Radiology, University of California Davis Medical Center, Sacramento, California, USA
Address correspondence to John P. McGahan, MD, Department of Radiology, 4860 Y St, Suite 3100, Sacramento, CA 95817 USA. Email: [email protected]Search for more papers by this authorHeather Early MD
Department of Radiology, University of California Davis Medical Center, Sacramento, California, USA
Search for more papers by this authorJorge Aguilera BS
Department of Radiology, University of California Davis Medical Center, Sacramento, California, USA
Search for more papers by this authorEllen Cheang MD
Department of Radiology, University of California Davis Medical Center, Sacramento, California, USA
Search for more papers by this authorCorresponding Author
John McGahan MD
Department of Radiology, University of California Davis Medical Center, Sacramento, California, USA
Address correspondence to John P. McGahan, MD, Department of Radiology, 4860 Y St, Suite 3100, Sacramento, CA 95817 USA. Email: [email protected]Search for more papers by this authorInstitutional Research Grant to U.C. Davis from GE Medical to study liver and renal shear wave elastography.
Abstract
The gold standard in evaluating renal allograft dysfunction has traditionally been renal biopsy. However, not only does biopsy come with inherent risks, the time frame from biopsy to detecting renal dysfunction is often inefficient. It is therefore advantageous to have a noninvasive, low-cost, time-saving method, such as shear wave elastography (SWE), to detect fibrosis early, to maximize immunosuppressive care. It is important to consider factors that affect tissue stiffness in the kidney, as well as the challenges incurred when using SWE in this anisotropic organ, in order to select the most appropriate patients for this exam.
References
- 1 Joosten SA, Sijpkens YW, van Kooten C, Paul LC. Chronic renal allograft rejection: pathophysiologic considerations. Kidney Int 2005; 68: 1–13.
- 2 Nankivell BJ, Borrows RJ, Fung CL, O'Connell PJ, Allen RD, Chapman JR. The natural history of chronic allograft nephropathy. N Engl J Med 2003; 349: 2326–2333.
- 3 Seron D, Arns W, Chapman JR. Chronic allograft nephropathy—clinical guidance for early detection and early intervention strategies. Nephrol Dial Transplant 2008; 23: 2467–2473.
- 4 Racusen LC, Solez K, Colvin RB, et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999; 55: 713–723.
- 5 Monaco AP, Burke JF Jr, Ferguson RM, et al. Current thinking on chronic renal allograft rejection: issues, concerns, and recommendations from a 1997 roundtable discussion. Am J Kidney Dis 1999; 33: 150–160.
- 6 Furness PN, Taub N; Convergence of European Renal Transplant Pathology Assessment Procedures Project. International variation in the interpretation of renal transplant biopsies: report of the CERTPAP Project. Kidney Int 2001; 60: 1998–2012.
- 7 Schwarz A, Gwinner W, Hiss M, Radermacher J, Mengel M, Haller H. Safety and adequacy of renal transplant protocol biopsies. Am J Transplant 2005; 5: 1992–1996.
- 8 Sandrin L, Fourquet B, Hasquenoph JM, et al. Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med Biol 2003; 29: 1705–1713.
- 9 Shiina T, Nightingale KR, Palmeri ML, et al. WFUMB guidelines and recommendations for clinical use of ultrasound elastography, Part 1: basic principles and terminology. Ultrasound Med Biol 2015; 41: 1126–1147.
- 10 Shah NS, Kruse SA, Lager DJ, et al. Evaluation of renal parenchymal disease in a rat model with magnetic resonance elastography. Magn Reson Med 2004; 52: 56–64.
- 11 Warner L, Yin M, Glaser KJ, et al. Noninvasive in vivo assessment of renal tissue elasticity during graded renal ischemia using MR elastography. Invest Radiol 2011; 46: 509–514.
- 12 Tang A, Cloutier G, Szeverenyi NM, Sirlin CB. Ultrasound elastography and MR elastography for assessing liver fibrosis. Part 1: principles and techniques. AJR Am J Roentgenol 2015; 205: 22–32.
- 13 Bamber J, Cosgrove D, Dietrich CF, et al. EFSUMB guidelines and recommendations on the clinical use of ultrasound elastography. Part 1: basic principles and technology. Ultraschall Med 2013; 34: 169–184.
- 14 Grenier N, Gennisson JL, Cornelis F, Le Bras Y, Couzi L. Renal ultrasound elastography. Diagn Interv Imaging 2013; 94: 545–550.
- 15 de Ledinghen V, Vergniol J. Transient elastography (FibroScan). Gastroenterol Clin Biol 2008; 32: 58–67.
- 16 Sporea I, Bota S, Jurchis A, et al. Acoustic radiation force impulse and supersonic shear imaging versus transient elastography for liver fibrosis assessment. Ultrasound Med Biol 2013; 39: 1933–1941.
- 17 GE Healthcare. LOGIQ E9 Shear Wave Elastography Whitepaper. 2015.
- 18 Nguyen-Khac E, Capron D. Noninvasive diagnosis of liver fibrosis by ultrasonic transient elastography (Fibroscan). Eur J Gastroenterol Hepatol 2006; 18: 1321–1325.
- 19 Castera L, Foucher J, Bernard PH, et al. Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations. Hepatology 2010; 51: 828–835.
- 20 Gennisson JL, Grenier N, Combe C, Tanter M. Supersonic shear wave elastography of in vivo pig kidney: influence of blood pressure, urinary pressure and tissue anisotropy. Ultrasound Med Biol 2012; 38: 1559–1567.
- 21 Grenier N, Poulain S, Lepreux S, et al. Quantitative elastography of renal transplants using supersonic shear imaging: a pilot study. Eur Radiol 2012; 22: 2138–2146.
- 22 Asano K, Ogata A, Tanaka K, et al. Acoustic radiation force impulse elastography of the kidneys: is shear wave velocity affected by tissue fibrosis or renal blood flow? J Ultrasound Med 2014; 33: 793–801.
- 23 Syversveen T, Brabrand K, Midtvedt K, et al. Assessment of renal allograft fibrosis by acoustic radiation force impulse quantification—a pilot study. Transpl Int 2011; 24: 100–105.
- 24 Syversveen T, Midtvedt K, Berstad AE, Brabrand K, Strom EH, Abildgaard A. Tissue elasticity estimated by acoustic radiation force impulse quantification depends on the applied transducer force: an experimental study in kidney transplant patients. Eur Radiol 2012; 22: 2130–2137.