The Burden of Colorectal Cancer Treatment on Quality of Life: A Paired Longitudinal Analysis of Medicare Advantage Enrollees
Emna Bakillah
Department of Surgery, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Surgery, Center for Surgery and Health Economics, Philadelphia, Pennsylvania, USA
Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorCorresponding Author
J. Walker Rosenthal
Department of Surgery, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Surgery, Center for Surgery and Health Economics, Philadelphia, Pennsylvania, USA
Correspondence: J. Walker Rosenthal ([email protected])
Search for more papers by this authorSolomiya Syvyk
Department of Surgery, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Surgery, Center for Surgery and Health Economics, Philadelphia, Pennsylvania, USA
Search for more papers by this authorChris Wirtalla
Department of Surgery, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Surgery, Center for Surgery and Health Economics, Philadelphia, Pennsylvania, USA
Search for more papers by this authorJames Sharpe
Department of Surgery, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Surgery, Center for Surgery and Health Economics, Philadelphia, Pennsylvania, USA
Search for more papers by this authorRaina M. Merchant
Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Emergency Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorShivan J. Mehta
Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Division of Gastroenterology, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorCarmen E. Guerra
Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorRachel R. Kelz
Department of Surgery, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Surgery, Center for Surgery and Health Economics, Philadelphia, Pennsylvania, USA
Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorEmna Bakillah
Department of Surgery, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Surgery, Center for Surgery and Health Economics, Philadelphia, Pennsylvania, USA
Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorCorresponding Author
J. Walker Rosenthal
Department of Surgery, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Surgery, Center for Surgery and Health Economics, Philadelphia, Pennsylvania, USA
Correspondence: J. Walker Rosenthal ([email protected])
Search for more papers by this authorSolomiya Syvyk
Department of Surgery, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Surgery, Center for Surgery and Health Economics, Philadelphia, Pennsylvania, USA
Search for more papers by this authorChris Wirtalla
Department of Surgery, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Surgery, Center for Surgery and Health Economics, Philadelphia, Pennsylvania, USA
Search for more papers by this authorJames Sharpe
Department of Surgery, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Surgery, Center for Surgery and Health Economics, Philadelphia, Pennsylvania, USA
Search for more papers by this authorRaina M. Merchant
Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Emergency Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorShivan J. Mehta
Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Division of Gastroenterology, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorCarmen E. Guerra
Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorRachel R. Kelz
Department of Surgery, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Department of Surgery, Center for Surgery and Health Economics, Philadelphia, Pennsylvania, USA
Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Search for more papers by this authorAbstract
Background and Objectives
Treatment of colorectal cancer (CRC) can have prolonged effects on health-related quality of life (HRQOL). Using the Medicare Health Outcomes Survey (MHOS), this study examines HRQOL outcomes among those undergoing CRC treatment and those who completed CRC treatment.
Methods
We performed a paired longitudinal retrospective cohort study of Medicare Advantage enrollees ≥ 65 years of age who completed the baseline and follow-up MHOS from 2016 to 2020 and answered survey questions regarding current CRC treatment. Outcomes included Physical Component Summary (PCS) scores and Mental Component Summary (MCS) scores. Multivariable logistic regression analyses were used.
Results
574 Respondents met the inclusion criteria. Those currently undergoing treatment for CRC had significantly lower PCS scores (β coefficient −3.08 points, p < 0.001) and significantly lower MCS scores (β coefficient −1.40 points, p = 0.008) at follow-up compared to when they were not undergoing CRC treatment at baseline. Respondents who completed CRC treatment had PCS and MCS scores that remained similar over time (β coefficient 0.54 points, p = 0.466 and 0.07 points, p = 0.924, respectively).
Discussion
Treatment of CRC negatively influences HRQOL. These findings emphasize the importance of informing patients of the long-term effects of CRC treatment and support the implementation of interventions aimed at providing sustained recovery throughout the survivorship continuum.
Open Research
Data Availability Statement
The data underlying this study are derived from the Medicare Health Outcomes Survey (MHOS), which is available through the Centers for Medicare & Medicaid Services (CMS). Access to the Medicare HOS data is restricted and requires approval from CMS to ensure compliance with legal and ethical standards, including the protection of patient confidentiality. Researchers may apply for access to the Medicare HOS data by submitting a data use agreement and following CMS's procedures.
Supporting Information
| Filename | Description |
|---|---|
| jso28161-sup-0001-MHOSpaired_Supplement.docx16.8 KB | MHOSpaired Supporting. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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