Research Article

Value of routine staging imaging studies for patients with stage III breast cancer

Corresponding Author

Caroline I. Piatek MD

[email protected]

Jane Anne Nohl Division of Hematology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California

Correspondence to: Caroline I. Piatek, MD, Jane Anne Nohl Division of Hematology, University of Southern California Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90033. Fax: +323-865-0060. E-mail: [email protected]

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Lingyun Ji MS,

Lingyun Ji MS

Department of Biostatistics, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California

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Chandan Kaur MS,

Chandan Kaur MS

University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California

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Christy A. Russell MD,

Christy A. Russell MD

Department of Medical Oncology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California

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Debu Tripathy MD,

Debu Tripathy MD

Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas

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Terry Church MA, MS, ABD,

Terry Church MA, MS, ABD

University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California

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Richard Sposto PhD,

Richard Sposto PhD

Department of Biostatistics, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California

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Stephen F. Sener MD,

Stephen F. Sener MD

Department of Surgery, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California

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Agustin A. Garcia MD,

Agustin A. Garcia MD

Department of Hematology/Oncology, Louisiana State University, New Orleans, Louisiana

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Caroline I. Piatek MD,

Corresponding Author

Caroline I. Piatek MD

[email protected]

Jane Anne Nohl Division of Hematology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California

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Lingyun Ji MS,

Lingyun Ji MS

Department of Biostatistics, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California

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Chandan Kaur MS,

Chandan Kaur MS

University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California

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Christy A. Russell MD,

Christy A. Russell MD

Department of Medical Oncology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California

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Debu Tripathy MD,

Debu Tripathy MD

Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas

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Terry Church MA, MS, ABD,

Terry Church MA, MS, ABD

University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California

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Richard Sposto PhD,

Richard Sposto PhD

Department of Biostatistics, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California

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Stephen F. Sener MD,

Stephen F. Sener MD

Department of Surgery, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California

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Agustin A. Garcia MD,

Agustin A. Garcia MD

Department of Hematology/Oncology, Louisiana State University, New Orleans, Louisiana

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First published: 19 September 2016

https://doi.org/10.1002/jso.24436

Citations: 3

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Abstract

Background and Objectives

Routine staging imaging studies (RSIS) are optional in stage III breast cancer (BC). The impact of RSIS on treatment decisions and patient outcomes has not been extensively studied. The goal of this study was to determine whether RSIS in stage III BC affected treatment or patient outcomes.

Methods

Stage III BC patients from 2000 to 2010 were retrospectively identified. RSIS results and treatment plan in response to RSIS results were recorded. Univariate and multivariate Cox proportional hazards regression models with time-dependent covariates were used to assess associations between RSIS use and recurrence-free survival (RFS).

Results

Of 420 patients, 362 (86.2%) received RSIS. RSIS were negative in 264 (72.9%), indeterminate in 77 (18.3%), and positive in 21 patients (5.0%) for metastatic disease. Treatment was altered in 21 (5.8%) patients based on RSIS results (20 with metastatic disease, 1 with indeterminate disease). There was no difference in RFS with RSIS use on multivariate analysis (hazard ratio 1.3; 95% confidence interval 0.73–2.5, P = 0.32).

Conclusions

Most stage III BC patients underwent RSIS, but RSIS results infrequently affected treatment decisions. There was no significant difference in RFS with RSIS use. RSIS to identify metastatic disease for stage III BC has limited value. J. Surg. Oncol. 2016;114:917–921. © 2016 Wiley Periodicals, Inc.

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Volume114, Issue8

December 15, 2016

Pages 917-921

Value of routine staging imaging studies for patients with stage III breast cancer

Abstract

Background and Objectives

Methods

Results

Conclusions

REFERENCES

Citing Literature

References

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Value of routine staging imaging studies for patients with stage III breast cancer

Abstract

Background and Objectives

Methods

Results

Conclusions

REFERENCES

Citing Literature

References

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