Research Article

Ability of FDG-PET/CT in the detection of gallbladder cancer

Corresponding Author

Carlos Ramos-Font MD, PhD

Nuclear Medicine Department, UGC Diagnóstico por la Imagen, Juan Ramón Jiménez Hospital, Huelva, Spain

Correspondence to: Carlos Ramos Font, MD, PhD, Nuclear Medicine Department, UGC Diagnóstico por la Imagen, Juan Ramón Jiménez Hospital, Ronda norte s/n 21005, Huelva, Spain.

E-mail: [email protected]

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Manuel Gómez-Rio MD, PhD,

Manuel Gómez-Rio MD, PhD

Nuclear Medicine Department, Virgen de las Nieves Hospital, Granada, Spain

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Antonio Rodríguez-Fernández MD, PhD,

Antonio Rodríguez-Fernández MD, PhD

Nuclear Medicine Department, Virgen de las Nieves Hospital, Granada, Spain

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Amelia Jiménez-Heffernan MD, PhD, FEBNM, FASNC,

Amelia Jiménez-Heffernan MD, PhD, FEBNM, FASNC

Nuclear Medicine Department, UGC Diagnóstico por la Imagen, Juan Ramón Jiménez Hospital, Huelva, Spain

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Rocío Sánchez Sánchez MD, PhD,

Rocío Sánchez Sánchez MD, PhD

Nuclear Medicine Department, Virgen de las Nieves Hospital, Granada, Spain

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Jose Manuel Llamas-Elvira MD, PhD,

Jose Manuel Llamas-Elvira MD, PhD

Nuclear Medicine Department, Virgen de las Nieves Hospital, Granada, Spain

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Carlos Ramos-Font MD, PhD,

Corresponding Author

Carlos Ramos-Font MD, PhD

Nuclear Medicine Department, UGC Diagnóstico por la Imagen, Juan Ramón Jiménez Hospital, Huelva, Spain

Correspondence to: Carlos Ramos Font, MD, PhD, Nuclear Medicine Department, UGC Diagnóstico por la Imagen, Juan Ramón Jiménez Hospital, Ronda norte s/n 21005, Huelva, Spain.

E-mail: [email protected]

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Manuel Gómez-Rio MD, PhD,

Manuel Gómez-Rio MD, PhD

Nuclear Medicine Department, Virgen de las Nieves Hospital, Granada, Spain

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Antonio Rodríguez-Fernández MD, PhD,

Antonio Rodríguez-Fernández MD, PhD

Nuclear Medicine Department, Virgen de las Nieves Hospital, Granada, Spain

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Amelia Jiménez-Heffernan MD, PhD, FEBNM, FASNC,

Amelia Jiménez-Heffernan MD, PhD, FEBNM, FASNC

Nuclear Medicine Department, UGC Diagnóstico por la Imagen, Juan Ramón Jiménez Hospital, Huelva, Spain

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Rocío Sánchez Sánchez MD, PhD,

Rocío Sánchez Sánchez MD, PhD

Nuclear Medicine Department, Virgen de las Nieves Hospital, Granada, Spain

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Jose Manuel Llamas-Elvira MD, PhD,

Jose Manuel Llamas-Elvira MD, PhD

Nuclear Medicine Department, Virgen de las Nieves Hospital, Granada, Spain

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First published: 25 October 2013

https://doi.org/10.1002/jso.23476

Citations: 54

Conflict of interest: none to declare.

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Abstract

Purpose

To assess the value of FDG-PET/CT in the evaluation of gallbladder carcinomas (GBC).

Methods

A prospective cohort of patients with suspicion of or confirmed GBC was studied with FDG-PET/CT. Diagnostic accuracy parameters were calculated in comparison with pathology and/or the clinical course of patients. Clinical impact of PET/CT imaging was estimated.

Results

Forty-nine patients were enrolled (34 malignant tumors, 15 benign lesions; 37 staging, 12 restaging). Overall diagnostic accuracy was 95.9% for the diagnosis of the primary lesion, 85.7% for lymph node involvement and 95.9% for metastatic disease. Mean SUV_max in malignant gallbladder lesions was 7.92 ± 6.25 Analysis of ROC curves showed a SUV_max cut-off value of 3.62 for malignancy (S: 78.1%; Sp: 88.2%). Diagnostic accuracy in the restaging group reached 100%. FDG-PET/CT changed the management of 22.4% of the population.

Comments

Diagnosis of malignancy or benignity of suspicious gallbladder lesions is accurately made with FDG PET/CT, allowing a precise staging of GBC due to its ability to identify unsuspected metastatic disease. SUV_max has a complementary role in addition to visual analysis. J. Surg. Oncol. 2014 109:218–224. © 2013 Wiley Periodicals, Inc.

REFERENCES

1 Randi G, Franceschi S, La Vecchia C: Gallbladder cancer worldwide: geographical distribution and risk factors. Int J Cancer 2006; 118: 1591–1602.
10.1002/ijc.21683
CAS PubMed Web of Science® Google Scholar
2 Chao T, Greager JA: Primary carcinoma of the gallbladder. J Surg Oncol 1991; 46: 215–221.
10.1002/jso.2930460402
PubMed Web of Science® Google Scholar
3 Eslick GD: Epidemiology of gallbladder cancer. Gastroenterol Clin N Am 2010; 39: 307–330.
10.1016/j.gtc.2010.02.011
PubMed Web of Science® Google Scholar
4 Reid KM, Ramos de la Medina A, Donohue A: Diagnosis and surgical management of gallbladder cancer: A Review. J Gastrointestinal Surg 2007; 11: 671–681.
10.1007/s11605-006-0075-x
PubMed Web of Science® Google Scholar
5 Miller G, Schwartz LH, D'Angelica M: The use of imaging in the diagnosis and staging of hepatobilliary malignancies. Surg Oncol Clin N Am 2007; 16: 343–368.
10.1016/j.soc.2007.04.001
PubMed Web of Science® Google Scholar
6 Rodríguez-Fernández A, Gómez-Río M, Medina-Benítez A, et al.: Application of modern imaging methods in diagnosis of gallbladder cancer. J Surg Oncol 2006; 93: 650–664.
10.1002/jso.20533
PubMed Web of Science® Google Scholar
7 Shukla PJ, Barreto SG, Arya S, et al.: Does PET-CT scan have a role prior to radical re-resection for incidental gallbladder cancer? HPB (Oxford) 2008; 10: 439–445.
10.1080/13651820802286910
PubMed Web of Science® Google Scholar
8 Koh T, Taniguchi H, Yamaguchi A, et al.: Differential diagnosis of gallbladder cancer using positron emission tomography with fluorine-18-labeled fluoro-deoxyglucose (FDG-PET). J Surg Oncol 2003; 84: 74–81.
10.1002/jso.10295
CAS PubMed Web of Science® Google Scholar
9 Rodríguez-Fernández A, Gómez-Río M, Llamas-Elvira JM, et al.: Positron-emission tomography with fluorine-18-fluoro-2-deoxy-D-glucose for gallbladder cancer diagnosis. Am J Surg 2004; 188: 171–175.
10.1016/j.amjsurg.2003.12.070
PubMed Web of Science® Google Scholar
10 Wakabayashi H, Akamoto S, Yachida S, et al.: Significance of fluorodeoxyglucose PET imaging in the diagnosis of malignancies in patients with biliary stricture. Eur J Surg Oncol 2005; 31: 1175–1179.
10.1016/j.ejso.2005.05.012
CAS PubMed Web of Science® Google Scholar
11 Oe A, Kawabe J, Torii K, et al.: Distinguishing benign from malignant gallbladder wall thickening using FDG-PET. Ann Nucl Med 2006; 20: 699–703.
10.1007/BF02984683
PubMed Web of Science® Google Scholar
12 Poeppel TD, Krause BJ, Heusner TA, et al.: PET/CT for the staging and follow-up of patients with malignancies. Eur J Radiol 2009; 70: 382–392.
10.1016/j.ejrad.2009.03.051
CAS PubMed Web of Science® Google Scholar
13 Ramos-Font C, Gómez-Río M, Rodríguez-Fernández A, et al.: Tomografía de positrones con 18F-fluor desoxiglucosa en la evaluación preoperatoria de lesiones de la vesícula biliar sospechosas de malignidad. Utilidad diagnóstica e impacto clínico. Rev Esp Med Nucl 2011; 30: 267–275.
10.1016/j.remn.2011.02.004
CAS Web of Science® Google Scholar
14 García Garzón JR, Rodríguez A, Cabrera A: Tomografía por emisión de positrones de cuerpo completo (PET/TAC) con 18F-fluorodesoxiglucosa. Rev Esp Med Nucl 2009; 28: 85–89.
10.1016/S0212-6982(09)70706-2
PubMed Web of Science® Google Scholar
15 Boellaard R, O'Doherty MJ, Weber WA, et al.: FDG PET and PET/CT: EANM procedure guidelines for tumor PET imaging: version 1.0. Eur J Nucl Med Mol Imaging 2010; 37: 181–200.
10.1007/s00259-009-1297-4
PubMed Web of Science® Google Scholar
16 Kula Z, Malkowski b, Pietrzak T, et al.: Initial evaluation of PET/CT imaging in patients with gallbladder carcinoma detected incidentally during or after cholecystectomy. Nowotwory 2007; 57: 225e–229e.
Google Scholar
17 Kumar R, Sharma P, Kumari A, et al.: Role of 18F-FDG PET/CT in detecting recurrent gallbladder carcinoma. Clin Nucl Med 2012; 37: 431–435.
10.1097/RLU.0b013e31824d24c4
PubMed Web of Science® Google Scholar
18 Lee SW, Kim HJ, Park JH, et al.: Clinical usefulness of 18F-FDG PET-CT for patients with gallbladder and cholangiocarcinoma. J Gastroenterol 2010; 45: 560–566.
10.1007/s00535-009-0188-6
PubMed Web of Science® Google Scholar
19 Rodríguez-Fernández A, Gómez-Río M, Llamas-Elvira JM: Functional imaging. In: CR Thomas, CD Fuller, editors. Billiary tract and gallbladder cancer. New York: Demos Medical Publishing; 2009; pp. 131–139.
Google Scholar
20 Maldjian PD, Ghesani N, Ahned S, et al.: Adenomyomatosis of the gallbladder: another cause for a “hot” gallbladder on 18F-FDG PET. AJR Am J Roentgenol 2007; 189: W36–W38.
10.2214/AJR.05.1284
PubMed Web of Science® Google Scholar
21 Murata Y, Watanabe H, Kubota K, et al.: PET/CT evaluation of the physiologic accumulation of 18F-FDG within the gallbladder vesicle. Nucl Med Biol 2007; 34: 961–966.
10.1016/j.nucmedbio.2007.07.006
CAS PubMed Web of Science® Google Scholar
22 Furukawa H, Ikuma H, Asakura K, et al.: Prognostic importance of standardized uptake value on F-18 fluorodeoxyglucose-positron emission tomography in biliary tract carcinoma. J Surg Oncol 2009; 100: 494–499.
10.1002/jso.21356
CAS PubMed Web of Science® Google Scholar
23 Butte JM, Redondo F, Waugh E, et al.: The role of PET-CT in patients with incidental gallbladder cancer. HPB (Oxford) 2009; 11: 585–591.
10.1111/j.1477-2574.2009.00104.x
PubMed Web of Science® Google Scholar
24 Petrowsky H, Wildbrett P, Husarik DB, et al.: Impact of integrated positron emission tomography and computed tomography on staging and management of gallbladder cancer and cholangiocarcinoma. J Hepatol 2006; 45: 43–50.
10.1016/j.jhep.2006.03.009
PubMed Web of Science® Google Scholar
25 Kobayashi S, Nagano H, Hoshino H, et al.: Diagnóstic value of FDG-PET for lymph node metastasis and outcome of surgery for biliary cancer. J Surg Oncol 2011; 103: 223–229.
10.1002/jso.21811
PubMed Web of Science® Google Scholar
26 Prabhakar HB, Rabinowitz CB, Gibbons FK, et al.: Imaging features of sarcoidosis on MDCT, FDG PET, and PET/CT. AJR Am J Roentgenol 2008; 190: S1–S6.
10.2214/AJR.07.7001
PubMed Web of Science® Google Scholar

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Volume109, Issue3

March 1, 2014

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Ability of FDG-PET/CT in the detection of gallbladder cancer

Abstract

Purpose

Methods

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Comments

REFERENCES

Citing Literature

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Ability of FDG-PET/CT in the detection of gallbladder cancer

Abstract

Purpose

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Results

Comments

REFERENCES

Citing Literature

References

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