Nodal status of central lymph nodes as a negative prognostic factor for papillary thyroid carcinoma†
Yoon Se Lee MD, PhD
Department of Otorhinolaryngology—Head and Neck Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
Search for more papers by this authorYun-Sung Lim MD
Department of Otorhinolaryngology—Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic of Korea
Search for more papers by this authorJin-Choon Lee MD, PhD
Department of Otorhinolaryngology—Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic of Korea
Search for more papers by this authorSoo-Geun Wang MD, PhD
Department of Otorhinolaryngology—Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic of Korea
Search for more papers by this authorIn-Ju Kim MD, PhD
Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic of Korea
Search for more papers by this authorSeok-Man Son MD, PhD
Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic of Korea
Search for more papers by this authorDong Hoon Shin MD, PhD
Department of Pathology, Pusan National University School of Medicine and Medical Research Institute, Yangsan, Kyeongnam, Republic of Korea
Search for more papers by this authorCorresponding Author
Byung-Joo Lee MD, PhD
Department of Otorhinolaryngology—Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic of Korea
Department of Otorhinolaryngology—Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital, 1-10, Ami-dong, Seo-gu, Pusan 602-739, Republic of Korea. Fax: +82-51-246-8668.===Search for more papers by this authorYoon Se Lee MD, PhD
Department of Otorhinolaryngology—Head and Neck Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
Search for more papers by this authorYun-Sung Lim MD
Department of Otorhinolaryngology—Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic of Korea
Search for more papers by this authorJin-Choon Lee MD, PhD
Department of Otorhinolaryngology—Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic of Korea
Search for more papers by this authorSoo-Geun Wang MD, PhD
Department of Otorhinolaryngology—Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic of Korea
Search for more papers by this authorIn-Ju Kim MD, PhD
Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic of Korea
Search for more papers by this authorSeok-Man Son MD, PhD
Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic of Korea
Search for more papers by this authorDong Hoon Shin MD, PhD
Department of Pathology, Pusan National University School of Medicine and Medical Research Institute, Yangsan, Kyeongnam, Republic of Korea
Search for more papers by this authorCorresponding Author
Byung-Joo Lee MD, PhD
Department of Otorhinolaryngology—Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic of Korea
Department of Otorhinolaryngology—Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital, 1-10, Ami-dong, Seo-gu, Pusan 602-739, Republic of Korea. Fax: +82-51-246-8668.===Search for more papers by this authorThe authors report no disclosures and have no financial interests.
Abstract
Background
The status of metastatic lymph nodes, including the size and extracapsular spread (ECS), in papillary thyroid cancer (PTC) has not been well established. This study evaluated the correlation between the specific status of central lymph node metastases (CLNM) and negative prognostic factors.
Methods
We reviewed 243 patients who underwent total thyroidectomy and neck dissection. The CLNM slides were reviewed and the relationship between the CLNM status and risk factors was analyzed.
Results
CLNM were found in 111 patients. ECS (+) was related to a large tumor, high number of CLNM, and large node (P < 0.05). Tumor size and number of CLNM were related to the ECS rate (OR = 3.861 and 2.491, respectively; P < 0.01) in a multivariate analysis. Large nodes (≥6 mm) were related to large tumor size, extrathyroidal extension, number of CLNM, and lateral cervical lymph node metastasis (LNM). Tumor size and LNM (OR = 4.519 and 7.811, respectively; P < 0.05) were related to large nodes in a multivariate analysis.
Conclusions
ECS was related to node size, tumor size, and number of CLNM. Node size was related to tumor size and LNM. Thus, specific nodal status is a possible prognostic factor for PTC. J. Surg. Oncol. 2013;107:777–782. © 2012 Wiley Periodicals, Inc.
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