Volume 87, Issue 1 pp. 32-38

Research Article

Detection of sentinel lymph nodes in gastric cancers based on immunohistochemical analysis of micrometastases

Tomoaki Karube MD,

Tomoaki Karube MD

Department of Academic Surgery (M9), Graduate School of Medicine, Chiba University, Chiba, Japan

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Takenori Ochiai MD, FACS,

Takenori Ochiai MD, FACS

Department of Academic Surgery (M9), Graduate School of Medicine, Chiba University, Chiba, Japan

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Hideaki Shimada MD, FACS,

Hideaki Shimada MD, FACS

Department of Academic Surgery (M9), Graduate School of Medicine, Chiba University, Chiba, Japan

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Takashi Nikaidou MD,

Takashi Nikaidou MD

Department of Pathology, Chiba University Hospital, Chiba, Japan

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Hideki Hayashi MD,

Corresponding Author

Hideki Hayashi MD

[email protected]

Research Center for Frontier Medical Engineering, Chiba University, Chiba, Japan

Research Center for Frontier Medical Engineering, Chiba University, 1-33, Yayoi-cho, Inage-ku, Chiba, Japan 263-8522. Fax: +81-43-290-3403Search for more papers by this author

Tomoaki Karube MD,

Tomoaki Karube MD

Department of Academic Surgery (M9), Graduate School of Medicine, Chiba University, Chiba, Japan

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Takenori Ochiai MD, FACS,

Takenori Ochiai MD, FACS

Department of Academic Surgery (M9), Graduate School of Medicine, Chiba University, Chiba, Japan

Search for more papers by this author

Hideaki Shimada MD, FACS,

Hideaki Shimada MD, FACS

Department of Academic Surgery (M9), Graduate School of Medicine, Chiba University, Chiba, Japan

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Takashi Nikaidou MD,

Takashi Nikaidou MD

Department of Pathology, Chiba University Hospital, Chiba, Japan

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Hideki Hayashi MD,

Corresponding Author

Hideki Hayashi MD

[email protected]

Research Center for Frontier Medical Engineering, Chiba University, Chiba, Japan

Research Center for Frontier Medical Engineering, Chiba University, 1-33, Yayoi-cho, Inage-ku, Chiba, Japan 263-8522. Fax: +81-43-290-3403Search for more papers by this author

First published: 21 June 2004

https://doi.org/10.1002/jso.20077

Citations: 26

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Abstract

Background and Objectives

The sentinel lymph node (SN) theory has the potential to change the trend of surgery for gastric cancer that is based on wide resection of the stomach with dissection of regional lymph nodes. However, feasibility tests of SN mapping procedures in gastric cancers with analysis of micrometastasis are rare. This study aimed to estimate the clinical usefulness of SN mapping using a dual procedure with dye- and gamma probe-guided techniques for gastric cancers, based on immunohistochemical staining (IHC) analysis.

Methods

SN mapping procedures were performed on 41 patients with T1-T2 gastric cancer, and gastrectomy with D2 lymphadenectomy followed. All SNs and non-SNs obtained from the patients were tested by IHC analysis using anti-cytokeratin antibodies.

Results

Using the dual mapping procedure, SNs were detected in all patients (100%). SN was positive in all patients with lymph node metastasis except in one with non-solid type poorly differentiated adenocarcinoma with marked lymphatic permeation, thus achieving an accuracy rate of 98%.

Conclusions

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Volume87, Issue1

15 July 2004

Pages 32-38

Detection of sentinel lymph nodes in gastric cancers based on immunohistochemical analysis of micrometastases

Abstract

Background and Objectives

Methods

Results

Conclusions

REFERENCES

Citing Literature

References

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Detection of sentinel lymph nodes in gastric cancers based on immunohistochemical analysis of micrometastases

Abstract

Background and Objectives

Methods

Results

Conclusions

REFERENCES

Citing Literature

References

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