Research Article

Thiourea and thiosemicarbazide derivatives structurally related to hexestrol: Synthesis and anticancer and other pharmacological properties

Corresponding Author

A.-Mohsen M. E. Omar

Department of Pharmacology, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt

Department of Pharmacology, Faculty of Pharmacy, University of Alexandria, Alexandria, EgyptSearch for more papers by this author

A. M. Farghaly,

A. M. Farghaly

Department of Pharmaceutical Chemistry, University of Alexandria, Alexandria, Egypt

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A. A. B. Hazzai,

A. A. B. Hazzai

Department of Pharmaceutical Chemistry, University of Alexandria, Alexandria, Egypt

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N. H. Eshba,

N. H. Eshba

Department of Pharmaceutical Chemistry, University of Alexandria, Alexandria, Egypt

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F. M. Sharabi,

F. M. Sharabi

Department of Pharmacology, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt

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T. T. Daabees,

T. T. Daabees

Department of Pharmacology, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt

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A.-Mohsen M. E. Omar,

Corresponding Author

A.-Mohsen M. E. Omar

Department of Pharmacology, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt

Department of Pharmacology, Faculty of Pharmacy, University of Alexandria, Alexandria, EgyptSearch for more papers by this author

A. M. Farghaly,

A. M. Farghaly

Department of Pharmaceutical Chemistry, University of Alexandria, Alexandria, Egypt

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A. A. B. Hazzai,

A. A. B. Hazzai

Department of Pharmaceutical Chemistry, University of Alexandria, Alexandria, Egypt

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N. H. Eshba,

N. H. Eshba

Department of Pharmaceutical Chemistry, University of Alexandria, Alexandria, Egypt

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F. M. Sharabi,

F. M. Sharabi

Department of Pharmacology, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt

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T. T. Daabees,

T. T. Daabees

Department of Pharmacology, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt

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First published: September 1981

https://doi.org/10.1002/jps.2600700928

Citations: 5

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Abstract

Two novel series of thio compounds bearing internal structural modifications of hexestrol were synthesized as potential anticancer agents. The first contains several N-substituted thiourea functions, and the second contains various N⁴-substituted-3-thiosemicarbazide moieties in place of one α-ethyl group of hexestrol dimethyl ether. The products showed no antileukemic activity in the P-388 lymphocytic leukemia system and did not exhibit any anticonvulsant or estrogenic properties.

References

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Volume70, Issue9

September 1981

Pages 1075-1079

Thiourea and thiosemicarbazide derivatives structurally related to hexestrol: Synthesis and anticancer and other pharmacological properties

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Thiourea and thiosemicarbazide derivatives structurally related to hexestrol: Synthesis and anticancer and other pharmacological properties

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