Volume 64, Issue 5 pp. 802-805
Research Article

Viscosities of acacia and sodium alginate after sterilization by cobalt-60

Alan W. Hartman

Alan W. Hartman

School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64110

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Russell U. Nesbitt Jr

Russell U. Nesbitt Jr

School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64110

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F. Mauriece Smith

F. Mauriece Smith

School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64110

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Noel O. Nuessle

Corresponding Author

Noel O. Nuessle

School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64110

School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64110Search for more papers by this author
First published: May 1975
Citations: 4

Abstract

Acacia and sodium alginate powders were sterilized by cobalt-60 irradiation to a total dose of 2.5 Mrad with no increase in residual radioactivity of the gums as a result of the treatment. Viscosity measurements showed an 11% reduction in the viscosity of acacia in water and a 16% decrease in the intrinsic viscosity in barium chloride solution due to the irradiation. Viscosities of sodium alginate solutions in 0.1 N sodium chloride showed a 70% decrease in intrinsic viscosity, indicating changes in the molecular structure corresponding to degradation to 30% of the original degree of polymerization. This dose of γ-radiation from cobalt-60 is not an appropriate method of sterilization for these gums.

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