Comparison of analgesic effects of isosteric variations of salicylic acid and aspirin (acetylsalicylic acid)
Leon Thompkins
Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, CA 94143
Search for more papers by this authorCorresponding Author
K. H. Lee
Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, CA 94143
Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, CA 94143Search for more papers by this authorLeon Thompkins
Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, CA 94143
Search for more papers by this authorCorresponding Author
K. H. Lee
Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, CA 94143
Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, CA 94143Search for more papers by this authorAbstract
A reliable and sensitive method was used to compare the analgesic activities of salicylic acid and'aspirin (acetylsalicylic acid) and several phenoxy substituted isosteric pairs. Those isosteric compounds studied did not show analgesic activity. The analgesic activity of aspirin was more than twofold greater than that of salicylic acid.
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