Volume 56, Issue 5 pp. 1311-1319

Research Article

Amide Proton Transfer Could Provide More Accurate Lesion Characterization in the Transition Zone of the Prostate

Zixuan Guo MS,

Zixuan Guo MS

orcid.org/0000-0002-6772-1131

Department of Medical Imaging, Guilin Medical University, Guilin, China

Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China

These authors contributed equally to this work.

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Xiaoyan Qin MS,

Xiaoyan Qin MS

Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China

These authors contributed equally to this work.

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Ronghua Mu MS,

Ronghua Mu MS

Department of Medical Imaging, Guilin Medical University, Guilin, China

Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China

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Jian Lv BS,

Jian Lv BS

Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China

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Zhuoni Meng MS,

Zhuoni Meng MS

Department of Medical Imaging, Guilin Medical University, Guilin, China

Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China

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Wei Zheng MS,

Wei Zheng MS

Department of Medical Imaging, Guilin Medical University, Guilin, China

Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China

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Zeyu Zhuang MS,

Zeyu Zhuang MS

Department of Medical Imaging, Guilin Medical University, Guilin, China

Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China

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Xiqi Zhu MD, PhD,

Corresponding Author

Xiqi Zhu MD, PhD

[email protected]

Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China

Address reprint requests to: X.Z., No. 46 Chongxin Road, Xiangshan District, Guilin City, China. E-mail: [email protected]

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Zixuan Guo MS,

Zixuan Guo MS

orcid.org/0000-0002-6772-1131

Department of Medical Imaging, Guilin Medical University, Guilin, China

Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China

These authors contributed equally to this work.

Search for more papers by this author

Xiaoyan Qin MS,

Xiaoyan Qin MS

Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China

These authors contributed equally to this work.

Search for more papers by this author

Ronghua Mu MS,

Ronghua Mu MS

Department of Medical Imaging, Guilin Medical University, Guilin, China

Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China

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Jian Lv BS,

Jian Lv BS

Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China

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Zhuoni Meng MS,

Zhuoni Meng MS

Department of Medical Imaging, Guilin Medical University, Guilin, China

Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China

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Wei Zheng MS,

Wei Zheng MS

Department of Medical Imaging, Guilin Medical University, Guilin, China

Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China

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Zeyu Zhuang MS,

Zeyu Zhuang MS

Department of Medical Imaging, Guilin Medical University, Guilin, China

Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China

Search for more papers by this author

Xiqi Zhu MD, PhD,

Corresponding Author

Xiqi Zhu MD, PhD

[email protected]

Department of Medical Imaging, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China

Address reprint requests to: X.Z., No. 46 Chongxin Road, Xiangshan District, Guilin City, China. E-mail: [email protected]

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First published: 16 April 2022

https://doi.org/10.1002/jmri.28204

Citations: 4

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Abstract

Background

There is an overlap comparing transition zone prostate cancer (TZ PCa) and benign prostatic hyperplasia (BPH) on T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI), creating additional challenges for assessment of TZ tumors on MRI.

Purpose

To evaluate whether amide proton transfer-weighted (APTw) imaging provides new diagnostic ideas for TZ PCa.

Study type

Prospective.

Population

A total of 51 TZ PCa patients (age, 49–89), 44 stromal BPH (age, 57–92), and 45 glandular BPH patients (age, 56–92).

Field Strength/Sequence

A 3 T; T2WI turbo spin echo (TSE), quantitative T2*-weighted imaging, DWI echo planar imaging, 3D APTw TSE.

Assessment

Differences in APTw, apparent diffusion coefficient (ADC), and T2* among three lesions were compared by one-way analysis of variance (ANOVA). Regions of interest were drawn by two radiologists (X.Q.Z. and X.Y.Q., with 21 and 15 years of experience, respectively).

Statistical Tests

Multivariable logistic regression analyses; ANOVA with post hoc testing; receiver operator characteristic curve analysis; Delong test. Significance level: P < 0.05.

Results

APTw among TZ PCa, stromal BPH, and glandular BPH (3.48% ± 0.83% vs. 2.76% ± 0.49% vs. 2.72% ± 0.45%, respectively) were significantly different except between stromal BPH and glandular BPH (P > 0.99). Significant differences were found in ADC (TZ PCa 0.76 ± 0.16 × 10⁻³ mm²/sec vs. stromal BPH 0.91 ± 0.14 × 10⁻³ mm²/sec vs. glandular BPH 1.08 ± 0.18 × 10⁻³ mm²/sec) among three lesions. APTw (OR = 12.18, 11.80, respectively) and 1/ADC (OR = 703.87, 181.11, respectively) were independent predictors of TZ PCa from BPH and stromal BPH. The combination of APTw and ADC had better diagnostic performance in the identification of TZ PCa from BPH and stromal BPH.

Data Conclusion

APTw imaging has the potential to be of added value to ADC in differentiating TZ PCa from BPH and stromal BPH.

Evidence Level

Technical Efficacy

Stage 2

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Citing Literature

Volume56, Issue5

November 2022

Pages 1311-1319

Amide Proton Transfer Could Provide More Accurate Lesion Characterization in the Transition Zone of the Prostate

Abstract

Background

Purpose

Study type

Population

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

Evidence Level

Technical Efficacy

References

Citing Literature

References

Information

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Amide Proton Transfer Could Provide More Accurate Lesion Characterization in the Transition Zone of the Prostate

Abstract

Background

Purpose

Study type

Population

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

Evidence Level

Technical Efficacy

References

Citing Literature

References

Related

Information