Volume 56, Issue 5 pp. 1591-1599

Research Article

Time-Resolved Noncontrast Magnetic Resonance Perfusion Imaging of Paraspinal Muscles

Mitsue Miyazaki PhD,

Mitsue Miyazaki PhD

orcid.org/0000-0002-5690-694X

Department of Radiology, University of California, San Diego, La Jolla, California, USA

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Asako Yamamoto MD,

Asako Yamamoto MD

orcid.org/0000-0003-4500-0269

Department of Radiology, Teikyo University School of Medicine, Tokyo, Japan

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Vadim Malis PhD,

Vadim Malis PhD

orcid.org/0000-0002-0426-1457

Department of Radiology, University of California, San Diego, La Jolla, California, USA

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Sheronda Statum MBA, DHA,

Sheronda Statum MBA, DHA

Department of Radiology, University of California, San Diego, La Jolla, California, USA

Department of Radiology, VA San Diego Healthcare System, San Diego, California, USA

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Christine B. Chung MD,

Christine B. Chung MD

Department of Radiology, University of California, San Diego, La Jolla, California, USA

Department of Radiology, VA San Diego Healthcare System, San Diego, California, USA

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Jesse Sozanski MD,

Jesse Sozanski MD

Department of Family Medicine, University of California, San Diego, La Jolla, California, USA

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Won C. Bae PhD,

Corresponding Author

Won C. Bae PhD

[email protected]

orcid.org/0000-0003-2616-0339

Department of Radiology, University of California, San Diego, La Jolla, California, USA

Department of Radiology, VA San Diego Healthcare System, San Diego, California, USA

Address reprint requests to: W.C.B., 9427 Health Sciences Drive, San Diego, CA 92093, USA. Email: [email protected]

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Mitsue Miyazaki PhD,

Mitsue Miyazaki PhD

orcid.org/0000-0002-5690-694X

Department of Radiology, University of California, San Diego, La Jolla, California, USA

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Asako Yamamoto MD,

Asako Yamamoto MD

orcid.org/0000-0003-4500-0269

Department of Radiology, Teikyo University School of Medicine, Tokyo, Japan

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Vadim Malis PhD,

Vadim Malis PhD

orcid.org/0000-0002-0426-1457

Department of Radiology, University of California, San Diego, La Jolla, California, USA

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Sheronda Statum MBA, DHA,

Sheronda Statum MBA, DHA

Department of Radiology, University of California, San Diego, La Jolla, California, USA

Department of Radiology, VA San Diego Healthcare System, San Diego, California, USA

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Christine B. Chung MD,

Christine B. Chung MD

Department of Radiology, University of California, San Diego, La Jolla, California, USA

Department of Radiology, VA San Diego Healthcare System, San Diego, California, USA

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Jesse Sozanski MD,

Jesse Sozanski MD

Department of Family Medicine, University of California, San Diego, La Jolla, California, USA

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Won C. Bae PhD,

Corresponding Author

Won C. Bae PhD

[email protected]

orcid.org/0000-0003-2616-0339

Department of Radiology, University of California, San Diego, La Jolla, California, USA

Department of Radiology, VA San Diego Healthcare System, San Diego, California, USA

Address reprint requests to: W.C.B., 9427 Health Sciences Drive, San Diego, CA 92093, USA. Email: [email protected]

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First published: 22 February 2022

https://doi.org/10.1002/jmri.28123

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Abstract

Background

While evaluation of blood perfusion in lumbar paraspinal muscles is of interest in low back pain, it has not been performed using noncontrast magnetic resonance (MR) techniques.

Purpose

To introduce a novel application of a time-resolved, noncontrast MR perfusion technique for paraspinal muscles and demonstrate effect of exercise on perfusion parameters.

Study Type

Longitudinal.

Subjects

Six healthy subjects (27–48 years old, two females) and two subjects with acute low back pain (46 and 65 years old females, one with diabetes/obesity).

Field Strength/Sequence

3-T, MR perfusion sequence.

Assessment

Lumbar spines of healthy subjects were imaged axially at L3 level with a tag-on and tag-off alternating inversion recovery arterial spin labeling technique that suppresses background signal and acquires signal increase ratio (SIR) from the in-flow blood at varying inversion times (TI) from 0.12 seconds to 3.5 seconds. SIR vs. TI data were fit to determine the perfusion metrics of peak height (PH), time to peak (TTP), mean transit time, apparent muscle blood volume (MBV), and apparent muscle blood flow (MBF) in iliocostal, longissimus, and multifidus. Imaging was repeated immediately after healthy subjects performed a 20-minute walk, to determine the effect of exercise.

Statistical Tests

Repeated measures analysis of variance.

Results

SIR vs. TI data showed well-defined leading and trailing edges, with sharply increasing SIR to TI of approximately 500 msec subsiding quickly to near zero around TI of 1500 msec. After exercise, the mean SIR at every TI increased markedly, resulting in significantly higher PH, MBV, and MBF (each P < 0.001 and F > 28.9), and a lower TTP (P < 0.05, F = 4.5), regardless of the muscle. MBF increased 2- to 2.5-fold after exercise, similar to the expected increase in cardiac output, given the intensity of the exercise.

Data Conclusions

Feasibility of an MR perfusion technique for muscle perfusion imaging was demonstrated, successfully detecting significantly increased perfusion after exercise.

Level of Evidence

Technical Efficacy Stage

Conflict of Interest

Dr. Bae has a research funding from General Electric Healthcare and Dr. Miyazaki has a research funding from Canon Medical Systems. The remaining coauthors have no conflicts of interest.

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Volume56, Issue5

November 2022

Pages 1591-1599

Time-Resolved Noncontrast Magnetic Resonance Perfusion Imaging of Paraspinal Muscles

Abstract

Background

Purpose

Study Type

Subjects

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusions

Level of Evidence

Technical Efficacy Stage

Conflict of Interest

References

References

Information

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Time-Resolved Noncontrast Magnetic Resonance Perfusion Imaging of Paraspinal Muscles

Abstract

Background

Purpose

Study Type

Subjects

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusions

Level of Evidence

Technical Efficacy Stage

Conflict of Interest

References

References

Related

Information