Volume 52, Issue 2 pp. 448-458

Original Research

Normative Pancreatic Stiffness Levels and Related Influences Established by Magnetic Resonance Elastography in Volunteers

Youli Xu BS,

Youli Xu BS

orcid.org/0000-0003-4253-5911

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China

Youli Xu and Xiaoli Cai contributed equally to this work.Search for more papers by this author

Xiaoli Cai BS,

Xiaoli Cai BS

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China

Youli Xu and Xiaoli Cai contributed equally to this work.Search for more papers by this author

Yu Shi MD,

Corresponding Author

Yu Shi MD

[email protected]

orcid.org/0000-0003-1940-0074

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China

Address Reprint Requests to: Y. S., Department of Radiology, Shengjing Hospital, China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, 110004, China. E-mail: [email protected]Search for more papers by this author

Meng Yin PhD,

Meng Yin PhD

Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA

Search for more papers by this author

Gongyu Lan MD,

Gongyu Lan MD

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China

Search for more papers by this author

Xianyi Zhang BS,

Xianyi Zhang BS

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China

Search for more papers by this author

Ruoyun Ji BS,

Ruoyun Ji BS

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China

Search for more papers by this author

Chang Liu BS,

Chang Liu BS

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China

Search for more papers by this author

Youli Xu BS,

Youli Xu BS

orcid.org/0000-0003-4253-5911

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China

Youli Xu and Xiaoli Cai contributed equally to this work.Search for more papers by this author

Xiaoli Cai BS,

Xiaoli Cai BS

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China

Youli Xu and Xiaoli Cai contributed equally to this work.Search for more papers by this author

Yu Shi MD,

Corresponding Author

Yu Shi MD

[email protected]

orcid.org/0000-0003-1940-0074

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China

Meng Yin PhD,

Meng Yin PhD

Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA

Search for more papers by this author

Gongyu Lan MD,

Gongyu Lan MD

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China

Search for more papers by this author

Xianyi Zhang BS,

Xianyi Zhang BS

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China

Search for more papers by this author

Ruoyun Ji BS,

Ruoyun Ji BS

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China

Search for more papers by this author

Chang Liu BS,

Chang Liu BS

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China

Search for more papers by this author

First published: 14 January 2020

https://doi.org/10.1002/jmri.27052

Citations: 11

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Abstract

Background

Large-scale normative studies of pancreatic stiffness and potential influences have yet to be pursued via magnetic resonance elastography (MRE).

Purpose

To determine normative MRE-based pancreatic stiffness values and to examine related influential factors.

Study Type

Prospective.

Subjects

In all, 361 volunteers (men, 199; women, 162) with a median age of 54.0 years and a median body mass index (BMI) of 22.86 kg/m² were prospectively recruited. Those with no histories of smoking, alcohol abuse, and diabetes mellitus (DM) were grouped as healthy volunteers, designating all others as positive controls.

Field Strength/Sequence

Each volunteer underwent 3.0T pancreatic MRI at a frequency of 40 Hz.

Assessment

Pancreatic stiffness values, pancreatic width and volume, waist circumference, and wave distance were measured in all subjects.

Statistical Tests

Multiple linear regression analyses were performed to determine variables that influence MRE-determined stiffness.

Results

The mean pancreatic stiffness in all volunteers was 1.20 ± 0.16 kPa. Stiffness levels in positive control volunteers proved significantly greater than levels in healthy volunteers (1.29 ± 0.17 kPa vs. 1.14 ± 0.13 kPa; P < 0.001). In multiple linear regression analysis, sex (P = 0.004), BMI (P < 0.001), pancreatic width (P = 0.005), smoking (P < 0.001), alcohol abuse (P < 0.001), and DM (P = 0.001) emerged as significant independent factors impacting pancreatic stiffness. Smoking, alcohol abuse, DM, and wide pancreas were associated with greater pancreatic stiffness (coefficients = 0.202, 0.183, 0.149, and 0.160, respectively), while reduced pancreatic stiffness corresponded with female sex and larger BMI (coefficient = −0.155 and −0.192, respectively).

Data Conclusion

MRE-based pancreatic stiffness values are impacted by sex, BMI, pancreatic width, smoking, alcohol abuse, and DM. Reference values are essential for future clinical studies.

Level of Evidence: 1

Technical Efficacy: Stage 2

J. Magn. Reson. Imaging 2020;52:448–458.

Conflict of Interest

None of the authors have conflicts of interest or specific financial interests with respect to this subject matter.

Supporting Information

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Citing Literature

Volume52, Issue2

August 2020

Pages 448-458

Normative Pancreatic Stiffness Levels and Related Influences Established by Magnetic Resonance Elastography in Volunteers

Abstract

Background

Purpose

Study Type

Subjects

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

Conflict of Interest

Supporting Information

References

Citing Literature

References

Information

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