Volume 29, Issue 6 pp. 1367-1374
Original Research

Improved time-of-flight magnetic resonance angiography with IDEAL water-fat separation

Allison Grayev MD

Allison Grayev MD

University of Wisconsin, Department of Radiology, Madison, Wisconsin

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Ann Shimakawa PhD

Ann Shimakawa PhD

Global MR Applied Science Laboratory, Menlo Park, California

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Joseph Cousins MD, PhD

Joseph Cousins MD, PhD

University of Wisconsin, Department of Radiology, Madison, Wisconsin

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Patrick Turski MD

Patrick Turski MD

University of Wisconsin, Department of Radiology, Madison, Wisconsin

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Jean Brittain PhD

Jean Brittain PhD

Global MR Applied Science Laboratory, Madison, Wisconsin

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Scott Reeder MD, PhD

Corresponding Author

Scott Reeder MD, PhD

University of Wisconsin, Department of Radiology, Madison, Wisconsin

University of Wisconsin, Department of Medical Physics, Madison, Wisconsin

University of Wisconsin, Department of Biomedical Engineering, Madison, Wisconsin

University of Wisconsin, Department of Medicine, Madison, Wisconsin

Department of Radiology, E3/311 CSC, University of Wisconsin, 600 Highland Ave., Madison, WI 53792-3252Search for more papers by this author
First published: 26 May 2009
Citations: 16

Abstract

Purpose

To implement IDEAL (iterative decomposition of water and fat using echo asymmetry and least squares estimation) water-fat separation with 3D time-of-flight (TOF) magnetic resonance angiography (MRA) of intracranial vessels for improved background suppression by providing uniform and robust separation of fat signal that appears bright on conventional TOF-MRA.

Materials and Methods

IDEAL TOF-MRA and conventional TOF-MRA were performed in volunteers and patients undergoing routine brain MRI/MRA on a 3T magnet. Images were reviewed by two radiologists and graded based on vessel visibility and image quality.

Results

IDEAL TOF-MRA demonstrated statistically significant improvement in vessel visibility when compared to conventional TOF-MRA in both volunteer and clinical patients using an image quality grading system. Overall image quality was 3.87 (out of 4) for IDEAL versus 3.55 for conventional TOF imaging (P = 0.02). Visualization of the ophthalmic artery was 3.53 for IDEAL versus 1.97 for conventional TOF imaging (P < 0.00005) and visualization of the superficial temporal artery was 3.92 for IDEAL imaging versus 1.97 for conventional TOF imaging (P < 0.00005).

Conclusion

By providing uniform suppression of fat, IDEAL TOF-MRA provides improved background suppression with improved image quality when compared to conventional TOF-MRA methods. J. Magn. Reson. Imaging 2009;29:1367–1374. © 2009 Wiley-Liss, Inc.

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