Volume 29, Issue 6 pp. 1450-1456
Technical Note

Lower extremities magnetic resonance angiography with blood pressure cuff compression: Quantitative dynamic analysis

Marcel Koenigkam-Santos MD

Marcel Koenigkam-Santos MD

Department of Radiology, Emory University School of Medicine, Atlanta, Georgia

Department of Radiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil

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Puneet Sharma PhD

Puneet Sharma PhD

Department of Radiology, Emory University School of Medicine, Atlanta, Georgia

Emory Healthcare Clinics, Atlanta, Georgia

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Bobby Kalb MD

Bobby Kalb MD

Department of Radiology, Emory University School of Medicine, Atlanta, Georgia

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John Carew PhD

John Carew PhD

Department of Radiology, Emory University School of Medicine, Atlanta, Georgia

Department of Mathematics and Biostatistics, Emory University, Atlanta, Georgia

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John N. Oshinski PhD

John N. Oshinski PhD

Department of Radiology, Emory University School of Medicine, Atlanta, Georgia

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Diego Martin MD, PhD

Corresponding Author

Diego Martin MD, PhD

Department of Radiology, Emory University School of Medicine, Atlanta, Georgia

Emory Clinic Building A - AT622 1365 Clifton Rd. NE, Atlanta, GA 30322Search for more papers by this author
First published: 26 May 2009
Citations: 6

Abstract

Purpose

To quantitatively evaluate changes induced by the application of a femoral blood-pressure cuff (BPC) on run-off magnetic resonance angiography (MRA), which is a method generally previously proposed to reduce venous contamination in the leg.

Materials and Methods

This study was Health Insurance Portability and Accountability Act (HIPAA)- and Institutional Review Board (IRB)-compliant. We used time-resolved gradient-echo gadolinium (Gd)-enhanced MRA to measure BPC effects on arterial, venous, and soft-tissue enhancement. Seven healthy volunteers (six men) were studied with the BPC applied at the mid-femoral level unilaterally using a 1.5T MR system after intravenous injection of Gd-BOPTA. Different statistical tools were used such as the Wilcoxon signed rank test and a cubic smoothing spline fit.

Results

We found that BPC application induces delayed venous filling (as previously described), but also induces significant decreases in arterial inflow, arterial enhancement, vascular-soft tissue contrast, and delayed peak enhancement (which have not been previously measured).

Conclusion

The potential benefits from using a BPC for run-off MRA must be balanced against the potential pitfalls, elucidated by our findings. J. Magn. Reson. Imaging 2009;29:1450–1456. © 2009 Wiley-Liss, Inc.

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