Applications of magnetic resonance elastography to healthy and pathologic skeletal muscle
Stacie I. Ringleb PhD
Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic, College of Medicine, Rochester, Minnesota, USA
Search for more papers by this authorSabine F. Bensamoun PhD
Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic, College of Medicine, Rochester, Minnesota, USA
Search for more papers by this authorQingshan Chen MS
Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic, College of Medicine, Rochester, Minnesota, USA
Search for more papers by this authorArmando Manduca PhD
Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Search for more papers by this authorKai-Nan An PhD
Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic, College of Medicine, Rochester, Minnesota, USA
Search for more papers by this authorCorresponding Author
Richard L. Ehman MD
Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905Search for more papers by this authorStacie I. Ringleb PhD
Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic, College of Medicine, Rochester, Minnesota, USA
Search for more papers by this authorSabine F. Bensamoun PhD
Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic, College of Medicine, Rochester, Minnesota, USA
Search for more papers by this authorQingshan Chen MS
Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic, College of Medicine, Rochester, Minnesota, USA
Search for more papers by this authorArmando Manduca PhD
Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Search for more papers by this authorKai-Nan An PhD
Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic, College of Medicine, Rochester, Minnesota, USA
Search for more papers by this authorCorresponding Author
Richard L. Ehman MD
Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905Search for more papers by this authorAbstract
Magnetic resonance elastography (MRE) is capable of noninvasively quantifying the mechanical properties of skeletal muscles in vivo. This information can be clinically useful to understand the effects of pathologies on the mechanical properties of muscle and to quantify the effects of treatment. Advances in inversion algorithms quantify muscle anisotropy in two-dimensional (2D) and three-dimensional (3D) imaging. Databases of the shear stiffness of skeletal muscle have been presented in the relaxed and contracted states in the upper extremity (biceps brachii, flexor digitorum profundus, and upper trapezius), distal leg muscles (tibialis anterior, medial gastrocnemius, lateral gastrocnemius, and trapezius), and proximal leg muscles (vastus lateralis, vastus medialis, and sartorius). MRE measurements have successfully validated a mathematical model of skeletal muscle behavior in the biceps brachii, correlated to electromyographic data in the distal leg muscles and quantified the effects of pathologies on the distal and proximal leg muscles. Future research efforts should be directed toward improving one-dimensional (1D) and 3D MRE data acquisition and image processing, tracking the effects of treatment on pathologic muscle and correlating the shear stiffness with clinical measurements. J. Magn. Reson. Imaging 2007. © 2007 Wiley-Liss, Inc.
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