Muscle MRI in inherited neuromuscular disorders: Past, present, and future
Corresponding Author
Eugenio Mercuri MD
Department of Child Neurology and Psychiatry, Catholic University, Rome, Italy
Dubowitz Neuromuscular Centre, Department of Paediatrics, Imperial College, Hammersmith Hospital, London, United Kingdom
Neuropsichiatria Infantile, Policlinico Gemelli, Largo Gemelli, 00168 Roma, ItalySearch for more papers by this authorAnna Pichiecchio MD
Neuroradiology Department, Neurological Institute “Istituto Scientifico” “C. Mondino,” Pavia, Italy
Search for more papers by this authorJoanna Allsop DCR
Robert Steiner MRI Unit, Imperial College, Hammersmith Hospital, London, United Kingdom
Search for more papers by this authorSonia Messina MD
Department of Child Neurology and Psychiatry, Catholic University, Rome, Italy
Search for more papers by this authorMarika Pane MD
Department of Child Neurology and Psychiatry, Catholic University, Rome, Italy
Search for more papers by this authorFrancesco Muntoni MD
Dubowitz Neuromuscular Centre, Department of Paediatrics, Imperial College, Hammersmith Hospital, London, United Kingdom
Search for more papers by this authorCorresponding Author
Eugenio Mercuri MD
Department of Child Neurology and Psychiatry, Catholic University, Rome, Italy
Dubowitz Neuromuscular Centre, Department of Paediatrics, Imperial College, Hammersmith Hospital, London, United Kingdom
Neuropsichiatria Infantile, Policlinico Gemelli, Largo Gemelli, 00168 Roma, ItalySearch for more papers by this authorAnna Pichiecchio MD
Neuroradiology Department, Neurological Institute “Istituto Scientifico” “C. Mondino,” Pavia, Italy
Search for more papers by this authorJoanna Allsop DCR
Robert Steiner MRI Unit, Imperial College, Hammersmith Hospital, London, United Kingdom
Search for more papers by this authorSonia Messina MD
Department of Child Neurology and Psychiatry, Catholic University, Rome, Italy
Search for more papers by this authorMarika Pane MD
Department of Child Neurology and Psychiatry, Catholic University, Rome, Italy
Search for more papers by this authorFrancesco Muntoni MD
Dubowitz Neuromuscular Centre, Department of Paediatrics, Imperial College, Hammersmith Hospital, London, United Kingdom
Search for more papers by this authorAbstract
Interest in muscle MRI has been largely stimulated in the last few years by the recognition of an increasing number of genetic defects in the field of inherited neuromuscular disorders. Muscle ultrasound (US) and computed tomography (CT) have been used to detect the presence of muscle involvement in patients affected by these disorders, but until recently the use of muscle MRI has been, with a few exceptions, limited to detecting inflammatory forms. The aim of this review is to illustrate how muscle MRI, in combination with clinical evaluation, can contribute to the selection of appropriate genetic tests and more generally in the differential diagnosis of genetically distinct forms of neuromuscular disorders. Possible future applications of muscle MRI are also discussed. J. Magn. Reson. Imaging 2007. © 2007 Wiley-Liss, Inc.
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