The derivatives of 1-propyl- and 1-butyl- of 2-methyl-5-nitroimidazole containing phenylpiperazine, m-chloro- and o-methoxyphenylpiperazine attached at the end of alkyl chain were synthesed. For the obtained new compounds, the biological activity was predicted using the computer program PASS.

References

1 Kuehler T. C.; Swanson M.; Christenson B.; Klitenberg A.-Ch; Lamm B.; Faegerhag J.; Sjoestroem J.-E. J. Med. Chem., 2002, 45, 4282.
10.1021/jm0208673
CAS PubMed Google Scholar
2 Josse O.; Labar D.; Georges B.; Gregoire V.; Marchand-Brynaert J. Bioorg. Med. Chem., 2001, 9, 665.
10.1016/S0968-0896(00)00279-0
CAS PubMed Web of Science® Google Scholar
3 Bersani C.; Berna M.; Pasut G.; Veronese F. M. Il Farmaco, 2005, 60, 78.
10.1016/j.farmac.2005.04.015
CAS Google Scholar
4 Demirayak S.; Karaburun A. C.; Kiraz N. Eur. J. Med. Chem., 1999, 34, 275.
10.1016/S0223-5234(99)80062-2
CAS Web of Science® Google Scholar
5 Leduc G.; Debregeas P.; Bernabe D., Int. Appl. WO Patent 2000069414, 2000.
Google Scholar
Chem. Abstr. 2001, 134, 9358.
Google Scholar
6 Makovec F.; Senin P.; Rovati L., Brit. UK. Patent 2022073, 1979.
Google Scholar
Chem. Abstr. 1980, 93, 95294f.
Google Scholar
7 Brown J. M. J. Cancer., 1993, 67, 1163.
10.1038/bjc.1993.220
CAS PubMed Web of Science® Google Scholar
8 Mikiciuk-Olasik E.; Blaszczak-Świąkiewicz K. Wiad. Chem., 2000, 54, 713.
Google Scholar
9 Monge A.; Palop J. A. J. Med. Chem., 1995, 40, 1786.
10.1021/jm00010a023
Web of Science® Google Scholar
10 Benakli K.; Terme T.; Vanelle P. Molecules, 2002, 7, 382.
10.3390/70400382
CAS Web of Science® Google Scholar
11 Silvestri R.; Artico M.; Massa S.; Marceddu T.; De Montis F.; La Colla P. Bioorg. Med. Chem. Lett., 2000, 10, 253.
10.1016/S0960-894X(99)00664-2
CAS PubMed Web of Science® Google Scholar
12 Kowalski P.; Nowak K.; Szpakiewicz B. J. Heterocyclic Chem., 2005, 42, 883.
10.1002/jhet.5570420521
CAS Web of Science® Google Scholar
13 http://www.ibmh.msk.su/PASS
Google Scholar

Citing Literature

Volume45, Issue4

July/August 2008

Pages 1247-1250

Synthesis of new imidazole derivatives

Abstract

References

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Synthesis of new imidazole derivatives

Abstract

References

Citing Literature

References

Related

Information