Echolucency of carotid plaques and cerebrovascular events
Evren Aldemir MD
Radiology Clinic, Trabzon Vakfıkebir Health Ministry Hospital, Trabzon, Turkey
Search for more papers by this authorCorresponding Author
Melda Apaydin MD
Department of Radiology, Izmir Ataturk Education and Research Hospital, Izmir, Turkey
Department of Radiology, Izmir Ataturk Education and Research Hospital, Izmir, TurkeySearch for more papers by this authorMakbule Varer MD
Department of Radiology, Izmir Ataturk Education and Research Hospital, Izmir, Turkey
Search for more papers by this authorEngin Uluc MD
Department of Radiology, Izmir Ataturk Education and Research Hospital, Izmir, Turkey
Search for more papers by this authorEvren Aldemir MD
Radiology Clinic, Trabzon Vakfıkebir Health Ministry Hospital, Trabzon, Turkey
Search for more papers by this authorCorresponding Author
Melda Apaydin MD
Department of Radiology, Izmir Ataturk Education and Research Hospital, Izmir, Turkey
Department of Radiology, Izmir Ataturk Education and Research Hospital, Izmir, TurkeySearch for more papers by this authorMakbule Varer MD
Department of Radiology, Izmir Ataturk Education and Research Hospital, Izmir, Turkey
Search for more papers by this authorEngin Uluc MD
Department of Radiology, Izmir Ataturk Education and Research Hospital, Izmir, Turkey
Search for more papers by this authorAbstract
Objectives.
To assess the relationship between carotid plaque echogenicity and degree of stenosis with acute and chronic stroke.
Methods.
A retrospective study of cerebral MRI and carotid B-mode and Doppler ultrasonography in 60 patients with stroke. Plaque echogenicity was graded as echolucent (1), predominantly echolucent (2), predominantly echogenic (3), or echogenic (4). Sonographic findings were compared between patients with acute (group 1) and chronic (group 2) stroke.
Results.
In group 1 (n = 39 patients), the carotid plaques were grade 1 in 21, grade 2 in 22, grade 3 in 9, and grade 4 in 4 carotid arteries. In group 2 (n = 21), the carotid plaques were grade 1 in 2, grade 2 in 8, grade 3 in 4, and grade 4 in 11 carotid arteries. Plaque echogenicity was lower in group 1 than in group 2 (p < 0.05). Plaque echolucency was associated independently with acute stroke from the degree of stenosis.
Conclusions.
Patients with acute infarcts have predominantly echolucent plaques, regardless of the degree of stenosis. © 2012 Wiley Periodicals, Inc. J Clin Ultrasound 40:399–404, 2012
REFERENCES
- 1 Lee EJ,Kim HJ,Bae JM, et al. Relevance of common carotid intima-media thickening and carotid plaque as risk factors for ischemic stroke in patients with type 2 diabetes mellitus. AJNR Am J Neuroradiol 2007; 28: 916.
- 2 Davis PH,Dawson JD,Riley WA, et al. Carotid intima-medial thickening is related to cardiovascular risk factors measured from childhood through middle age. The Muscatine study. Circulation 2001; 104: 2815.
- 3 O'Leary DH,Polak JF,Kronmal RA, et al. Carotid artery intima and media thickening as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 1999; 340: 14.
- 4 Nikic P,Savic M,Jakovljevic V, et al. Carotid atherosclerosis, coronary atherosclerosis and carotid intima-media thickening in patients with ischemic cerebral disease: is there any link? Exp Clin Cardiol 2006; 11: 102.
- 5 Rothwell PM,Gibson R,Warlow CP, on behalf of the European Carotid Surgery Trialists' Collaborative Group. Interrelation between plaque surface morphology and degree of stenosis on carotid angiograms and the risk of ischemic stroke in patients with symptomatic carotid stenosis. Stroke 2000; 31: 615.
- 6 Sabetai MM,Tegos TJ,Nicolaides AN, et al. Hemispheric symptoms and carotid plaque echomorphology. J Vasc Surg 2000; 31: 39.
- 7 Ouhlous M,Flach HZ,de Weert TT, et al. Carotid plaque composition and cerebral infarction: MR imaging study. AJNR Am J Neuroradiol 2005; 26: 1044.
- 8 Prabhakaran S,Rundek T,Ramas R, et al. Carotid plaque surface irregularity predicts ischemic stroke: the northern Manhattan study. Stroke 2006; 37: 2696.
- 9 Mintorovich J,Yang GY,Shimizu H, et al. Diffusion-weighted magnetic resonance imaging of acute focal cerebral ischemia: comparison of signal intensity with changes in brain water and Na+, K(+)-ATPase activity. J Cereb Blood Flow Metab 1994; 14: 332.
- 10 Gonzalez RG,Schaefer PW,Buonanno FS, et al. Diffusion-weighted MR imaging: diagnostic accuracy in patients imaged within 6 hours of stroke symptom onset. Radiology 1999; 210: 155.
- 11 Lovblad K,Laubach H,Baird A, et al. Clinical experience with diffusion-weighted MR in patients with acute stroke. AJNR Am J Neuroradiol 1998; 19: 1061.
- 12 Schaefer PW,Copen WA,Lev MH, et al. Diffusion-weighted imaging in acute stroke. Magn Reson Imaging Clin N Am 2006; 14: 141.
- 13 European Carotid Surgery Trialists' Collaborative Group. Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet 1998; 351: 1379.
- 14 Grant EG,Benson CB,Moneta GL, et al. Carotid artery stenosis: gray-scale and Doppler US diagnosis—Society of Radiologists in Ultrasound Consensus Conference. Radiology 2003; 229: 340.
- 15 Gray-Weale AC,Graham JC,Burnett JR, et al. Carotid artery atheroma: comparison of preoperative B-mode ultrasound appearance with carotid endarterectomy specimen pathology. J Cardiovasc Surg 1988; 29: 676.
- 16 Geroulakos G,Domjan J,Nicolaides A, et al. Ultrasonic carotid artery plaque structure and the risk of cerebral infarction on computed tomography. J Vasc Surg 1994; 20: 263.
- 17 Kalogeropoulos A,Terzis G,Chrysanthopoulou A, et al. Risk for transient ischemic attacks is mainly determined by intima-media thickening and carotid plaque echogenicity. Atherosclerosis 2007; 192: 190.
- 18 Tegos TJ,Sabetai MM,Nicolaides AN, et al. Patterns of brain computed tomography infarction and carotid plaque echogenicity. J Vasc Surg 2001; 33: 334.
- 19 Streifler JY,Eliaziw M,Fox AJ, et al. North American Symptomatic Carotid Endarterectomy Trial. Angiographic detection of carotid plaque ulceration: comparison with surgical observations in a multicenter study. Stroke 1994; 25: 1130.
- 20 Eliasziw M,Streifler JY,Fox AJ, et al. North American Symptomatic Carotid Endarterectomy Trial. Significance of plaque ulceration in symptomatic patients with high-grade carotid stenosis. Stroke 1994; 25: 304.
- 21 Matsagas MI,Vasdekis SN,Gugulakis AG, et al. Computer-assisted ultrasonographic analysis of carotid plaques in relation to cerebrovascular symptoms, cerebral infarction, and histology. Ann Vasc Surg 2000; 14: 130.
- 22 Ding S,Zhang M,Zhao Y, et al. The role of carotid plaque vulnerability and inflammation in the pathogenesis of acute ischemic stroke. Am J Med Sci 2008; 336: 27.
- 23 Tegos TJ,Sohail M,Sabetai MM, et al. Echomorphologic and histopathologic characteristics of unstable carotid plaques. AJNR Am J Neuroradiol 2000; 21: 1937.
- 24 Mathiesen EB,Bonaa KH,Joakimsen O. Echolucent plaques are associated with high risk of ischemic cerebrovascular events in carotid stenosis: the Tromsø study. Circulation 2001; 103: 2171.
- 25 Reiter M,Effenberger I,Sabeti S, et al. Increasing carotid plaque echolucency is predictive of cardiovascular events in high-risk patients. Radiology 2008; 248: 1050.
- 26 Yamashiro K,Watanabe T,Tanaka R, et al. Clustering of risk factors increases the incidence of echolucent carotid plaque in stroke patients. Cerebrovasc Dis 2006; 22: 432.
- 27 Fuster V,Moreno PR,Fayad ZA, et al. Atherothrombosis and high-risk plaque. I. Evolving concepts. J Am Coll Cardiol 2005; 46: 937.
- 28 Biasi GM,Froio A,Diethrich EB, et al. Carotid plaque echolucency increases the risk of stroke in carotid stenting: the Imaging in Carotid Angioplasty and Risk of Stroke (ICAROS) study. Circulation 2004; 110: 756.
- 29 Rosenkranz M,Wittkugel O,Waiblinger C, et al. Cerebral embolism during carotid artery stenting: role of carotid plaque echolucency. Cerebrovasc Dis 2009; 27: 443.
- 30 Uchiyama N,Misaki K,Mohri M, et al. Association between carotid plaque composition assessed by multidetector computed tomography and cerebral embolism after carotid stenting. Neuroradiology 2012; 54: 487.
- 31 van den Bouwhuijsen QJ,Vernooij MW,Hofman A, et al. Determinants of magnetic resonance imaging detected carotid plaque components:the Rotterdam Study. Eur Heart J 2012; 33: 221.
- 32 Liu X,Duan YY,Wang J, et al. In vitro model test and preliminary clinical application of a new method of ultrasonographic imaging: vascular enhancement technology. Ultrasound Med Biol 2009; 35: 1502.
- 33 Hermus L,van Dam GM,Zeebregts CJ. Advanced carotid plaque imaging. Eur J Vasc Endovasc Surg 2010; 39: 125.
- 34 Tu C,Ng TS,Sohi HK, et al. Receptor-targeted iron oxide nanoparticles for molecular MR imaging of inflamed atherosclerotic plaques. Biomaterials 2011; 32: 7209.
- 35 Hermus L,Tielliu IF,Wallis de Vries BM, et al. Imaging the vulnerable carotid artery plaque. Acta Chir Belg 2010; 110: 159.
- 36 Chalela JA. Evaluating the carotid plaque: going beyond stenosis. Cerebrovasc Dis 2009; 27: 19.
- 37 Nakamura T,Tsutsumi Y,Shimizu Y, et al. Ulcerated carotid plaques with ultrasonic echolucency are causatively associated with thromboembolic cerebrovascular events. J Stroke Cerebrovasc Dis 2011 Aug 4. [Epub ahead of print]
- 38 Savić ZN,Davidović L,Sagić D, et al. Correlation between morphologic carotid plaque findings based on color-Doppler and CT multidetector angiography with intraoperative findings in carotid artery stenosis. Vojnosanit Pregl 2010; 67: 449.
- 39 Johnsen SH,Mathiesen EB. Carotid plaque compared with intima-media thickening as a predictor of coronary and cerebrovascular disease. Curr Cardiol Rep 2009; 11: 21.
- 40 Brevetti G,Sirico G,Giugliano G, et al. Prevalence of hypoechoic carotid plaques in coronary artery disease: relationship with coexistent peripheral arterial disease and leukocyte number. Vasc Med 2009; 14: 13.