Journal of Biochemical and Molecular Toxicology

Volume 31, Issue 7 e21898

RESEARCH ARTICLE

Mechanism of capsaicin inhibition of aldose reductase activity

Zuhal Alim,

Corresponding Author

Zuhal Alim

[email protected]

Department of Chemistry, Faculty of Science and Arts, Ahi Evran University, 40000 Kırşehir, Turkey

Correspondence Zuhal Alim.Email: [email protected]Search for more papers by this author

Namık Kilinc,

Namık Kilinc

Department of Medical Services and Techniques, Vocational School of Health Service, Iğdır University, 76000 Iğdır, Turkey

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Bulent Sengul,

Bulent Sengul

Department of Health Care Service, Vocational School of Health Service, Bayburt University, 69000 Bayburt, Turkey

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Sukru Beydemir,

Sukru Beydemir

Department of Chemistry, Faculty of Sciences, Atatürk University, 25240 Erzurum, Turkey

Department of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey

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Zuhal Alim,

Corresponding Author

Zuhal Alim

[email protected]

Department of Chemistry, Faculty of Science and Arts, Ahi Evran University, 40000 Kırşehir, Turkey

Correspondence Zuhal Alim.Email: [email protected]Search for more papers by this author

Namık Kilinc,

Namık Kilinc

Department of Medical Services and Techniques, Vocational School of Health Service, Iğdır University, 76000 Iğdır, Turkey

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Bulent Sengul,

Bulent Sengul

Department of Health Care Service, Vocational School of Health Service, Bayburt University, 69000 Bayburt, Turkey

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Sukru Beydemir,

Sukru Beydemir

Department of Chemistry, Faculty of Sciences, Atatürk University, 25240 Erzurum, Turkey

Department of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey

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First published: 20 February 2017

https://doi.org/10.1002/jbt.21898

Citations: 20

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Abstract

Aldose reductase (AR) inhibitors play a vital importance as a potential therapeutic and preventive medicine when it comes to hyperglycemia associated diabetic complications. Additionally, capsaicin is used as a food additive and a drug in a number of diverse clinical trials. The aim of this study is to determine the in vitro inhibition behavior of capsaicin on AR enzyme activity, which was obtained from different rat tissues (heart, kidney, liver, and brain). We showed that AR was inhibited by capsaicin in the micromolar range and noncompetitive manner in all of the tissues. K_i values of capsaicin were found to be 8.87, 264, 535, and 597, respectively, in heart AR, kidney AR, liver AR, and brain AR. In conclusion, capsaicin may be an effective molecule when used in low concentrations to prevent diabetic complications associated with the polyol pathway.

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Volume31, Issue7

July 2017

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Mechanism of capsaicin inhibition of aldose reductase activity

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Mechanism of capsaicin inhibition of aldose reductase activity

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