Antibacterial efficacy of poly(vinyl alcohol) composite nanofibers embedded with silver-anchored silica nanoparticles
Abdul Wahab Jatoi
Nano Fusion Technology Research Lab, Division of Frontier Fibers, Institute for Fiber Engineering (IFES), Interdisciplinary Cluster for Cutting Edge Research (ICCER), Shinshu University 3-15-1, Tokida, Ueda, Nagono, 386-8567 Japan
Nanomaterial Research Group, Department of Textile Engineering, Mehran University of Engineering and Technology, Jamshoro, 76062 Pakistan
These authors contributed equally to this work.
Search for more papers by this authorYun Kee Jo
Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, 37673 Korea
These authors contributed equally to this work.
Search for more papers by this authorHoik Lee
Nano Fusion Technology Research Lab, Division of Frontier Fibers, Institute for Fiber Engineering (IFES), Interdisciplinary Cluster for Cutting Edge Research (ICCER), Shinshu University 3-15-1, Tokida, Ueda, Nagono, 386-8567 Japan
Search for more papers by this authorSeong-Geun Oh
Department of Chemical Engineering, Hanyang University, Seoul, 133-791 Korea
Search for more papers by this authorDong Soo Hwang
Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, 37673 Korea
Search for more papers by this authorZeeshan Khatri
Nanomaterial Research Group, Department of Textile Engineering, Mehran University of Engineering and Technology, Jamshoro, 76062 Pakistan
Search for more papers by this authorCorresponding Author
Hyung Joon Cha
Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, 37673 Korea
Correspondence to: I. S. Kim; E-mail: [email protected] or H. J. Cha; E-mail: [email protected]Search for more papers by this authorCorresponding Author
Ick Soo Kim
Nano Fusion Technology Research Lab, Division of Frontier Fibers, Institute for Fiber Engineering (IFES), Interdisciplinary Cluster for Cutting Edge Research (ICCER), Shinshu University 3-15-1, Tokida, Ueda, Nagono, 386-8567 Japan
Correspondence to: I. S. Kim; E-mail: [email protected] or H. J. Cha; E-mail: [email protected]Search for more papers by this authorAbdul Wahab Jatoi
Nano Fusion Technology Research Lab, Division of Frontier Fibers, Institute for Fiber Engineering (IFES), Interdisciplinary Cluster for Cutting Edge Research (ICCER), Shinshu University 3-15-1, Tokida, Ueda, Nagono, 386-8567 Japan
Nanomaterial Research Group, Department of Textile Engineering, Mehran University of Engineering and Technology, Jamshoro, 76062 Pakistan
These authors contributed equally to this work.
Search for more papers by this authorYun Kee Jo
Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, 37673 Korea
These authors contributed equally to this work.
Search for more papers by this authorHoik Lee
Nano Fusion Technology Research Lab, Division of Frontier Fibers, Institute for Fiber Engineering (IFES), Interdisciplinary Cluster for Cutting Edge Research (ICCER), Shinshu University 3-15-1, Tokida, Ueda, Nagono, 386-8567 Japan
Search for more papers by this authorSeong-Geun Oh
Department of Chemical Engineering, Hanyang University, Seoul, 133-791 Korea
Search for more papers by this authorDong Soo Hwang
Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, 37673 Korea
Search for more papers by this authorZeeshan Khatri
Nanomaterial Research Group, Department of Textile Engineering, Mehran University of Engineering and Technology, Jamshoro, 76062 Pakistan
Search for more papers by this authorCorresponding Author
Hyung Joon Cha
Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, 37673 Korea
Correspondence to: I. S. Kim; E-mail: [email protected] or H. J. Cha; E-mail: [email protected]Search for more papers by this authorCorresponding Author
Ick Soo Kim
Nano Fusion Technology Research Lab, Division of Frontier Fibers, Institute for Fiber Engineering (IFES), Interdisciplinary Cluster for Cutting Edge Research (ICCER), Shinshu University 3-15-1, Tokida, Ueda, Nagono, 386-8567 Japan
Correspondence to: I. S. Kim; E-mail: [email protected] or H. J. Cha; E-mail: [email protected]Search for more papers by this authorAbstract
Silver has been widely used as an effective antibacterial agent especially for treating burns and wounds. However, release of silver from materials often arouse side effects due to toxicity of silver towards mammalian cells. Argyria and argyrosis are well known problems of acute toxicity of silver towards human body. Immobilization of silver is an effective approach to reduce silver release. Herein, we present poly(vinyl alcohol) (PVA) composite nanofibers embedded with silver-anchored silica nanoparticles (SSNs) as a novel antibacterial material. Silver nanoparticles anchored on silica nanoparticles were prepared and incorporated into PVA nanofibers to fabricate silver-silica embedded PVA nanofibers (SSN-PVA) by electrospinning. Incorporation of SSNs into PVA was confirmed by TEM and SEM results revealed regular nanofibers whose diameter increased with successive addition of SSNs. The SSN-PVA nanofibers showed significant antibacterial efficacy against both Gram-negative and Gram-positive bacteria. Our research results demonstrated SSN-embedded polymeric nanofibers can open up a promising prospect for the prevention of bacterial infection in diverse biomedical fields including wound dressing. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1121–1128, 2018.
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