Clinical Device Related Article
Toward a skin-material interface with vacuum-integrated capped macroporous scaffolds
Gil D. Stynes,
George K. Kiroff,
Wayne A. Morrison,
Richard S. Page,
Mark A. Kirkland,
Corresponding Author
Gil D. Stynes
Barwon Biomedical Research, University Hospital Geelong, Geelong, Victoria, Australia
Department of Surgery, St Vincent's Hospital, University of Melbourne, Melbourne, Victoria, Australia
Commonwealth Scientific and Industrial Research Organisation, Melbourne, Victoria, Australia
Institute for Frontier Materials, Deakin University, Geelong, Victoria, Australia
Correspondence to: G. D. Stynes; e-mail: [email protected]Search for more papers by this authorGeorge K. Kiroff
Barwon Biomedical Research, University Hospital Geelong, Geelong, Victoria, Australia
Queen Elizabeth Hospital, The University of Adelaide, Adelaide, South Australia, Australia
Search for more papers by this authorWayne A. Morrison
Department of Surgery, St Vincent's Hospital, University of Melbourne, Melbourne, Victoria, Australia
Search for more papers by this authorRichard S. Page
School of Medicine, Deakin University, Geelong, Victoria, Australia
Search for more papers by this authorMark A. Kirkland
Barwon Biomedical Research, University Hospital Geelong, Geelong, Victoria, Australia
Institute for Frontier Materials, Deakin University, Geelong, Victoria, Australia
Search for more papers by this authorGil D. Stynes,
George K. Kiroff,
Wayne A. Morrison,
Richard S. Page,
Mark A. Kirkland,
Corresponding Author
Gil D. Stynes
Barwon Biomedical Research, University Hospital Geelong, Geelong, Victoria, Australia
Department of Surgery, St Vincent's Hospital, University of Melbourne, Melbourne, Victoria, Australia
Commonwealth Scientific and Industrial Research Organisation, Melbourne, Victoria, Australia
Institute for Frontier Materials, Deakin University, Geelong, Victoria, Australia
Correspondence to: G. D. Stynes; e-mail: [email protected]Search for more papers by this authorGeorge K. Kiroff
Barwon Biomedical Research, University Hospital Geelong, Geelong, Victoria, Australia
Queen Elizabeth Hospital, The University of Adelaide, Adelaide, South Australia, Australia
Search for more papers by this authorWayne A. Morrison
Department of Surgery, St Vincent's Hospital, University of Melbourne, Melbourne, Victoria, Australia
Search for more papers by this authorRichard S. Page
School of Medicine, Deakin University, Geelong, Victoria, Australia
Search for more papers by this authorMark A. Kirkland
Barwon Biomedical Research, University Hospital Geelong, Geelong, Victoria, Australia
Institute for Frontier Materials, Deakin University, Geelong, Victoria, Australia
Search for more papers by this authorThis article was published online on 10 March 2016. An error was subsequently identified. This notice is included in the online and print versions to indicate that both have been corrected 3 May 2016.
Abstract
Avulsion, epidermal marsupialization, and infection cause failure at the skin-material interface. A robust interface would permit implantable robotics, prosthetics, and other medical devices; reconstruction of surgical defects, and long-term access to blood vessels and body cavities. Torus-shaped cap-scaffold structures were designed to work in conjunction with negative pressure to address the three causes of failure. Six wounds were made on the backs of each of four 3-month old pigs. Four unmodified (no caps) scaffolds were implanted along with 20 cap-scaffolds. Collagen type 4 was attached to 21 implants. Negative pressure then was applied. Structures were explanted and assessed histologically at day 7 and day 28. At day 28, there was close tissue apposition to scaffolds, without detectable reactions from defensive or interfering cells. Three cap-scaffolds explanted at day 28 showed likely attachment of epidermis to the cap or cap-scaffold junction, without deeper marsupialization. The combination of toric-shaped cap-scaffolds with negative pressure appears to be an intrinsically biocompatible system, enabling a robust skin-material interface. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1307–1318, 2017.
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