Original Research Report
Low-frequency sonication may alter surface topography of endoprosthetic components and damage articular cartilage without eradicating biofilms completely
Gurpal Singh,
Rita Hameister,
Bernd Feuerstein,
Friedemann Awiszus,
Heiko Meyer,
Christoph H. Lohmann,
Gurpal Singh
Department of Orthopaedic Surgery, Otto-von-Guericke University, Magdeburg, Germany
University Orthopaedics, Hand and Reconstructive Microsurgery Cluster, National University Health System, Singapore, Singapore
Search for more papers by this authorRita Hameister
Department of Orthopaedic Surgery, Otto-von-Guericke University, Magdeburg, Germany
Search for more papers by this authorBernd Feuerstein
Department of Mechanical Engineering, Magdeburg-Stendal University of Applied Sciences, Magdeburg, Germany
Search for more papers by this authorFriedemann Awiszus
Department of Orthopaedic Surgery, Otto-von-Guericke University, Magdeburg, Germany
Search for more papers by this authorHeiko Meyer
Department of Orthopaedic Surgery, Otto-von-Guericke University, Magdeburg, Germany
Search for more papers by this authorCorresponding Author
Christoph H. Lohmann
Department of Orthopaedic Surgery, Otto-von-Guericke University, Magdeburg, Germany
Correspondence to: C. H. Lohmann (e-mail: [email protected])Search for more papers by this authorGurpal Singh,
Rita Hameister,
Bernd Feuerstein,
Friedemann Awiszus,
Heiko Meyer,
Christoph H. Lohmann,
Gurpal Singh
Department of Orthopaedic Surgery, Otto-von-Guericke University, Magdeburg, Germany
University Orthopaedics, Hand and Reconstructive Microsurgery Cluster, National University Health System, Singapore, Singapore
Search for more papers by this authorRita Hameister
Department of Orthopaedic Surgery, Otto-von-Guericke University, Magdeburg, Germany
Search for more papers by this authorBernd Feuerstein
Department of Mechanical Engineering, Magdeburg-Stendal University of Applied Sciences, Magdeburg, Germany
Search for more papers by this authorFriedemann Awiszus
Department of Orthopaedic Surgery, Otto-von-Guericke University, Magdeburg, Germany
Search for more papers by this authorHeiko Meyer
Department of Orthopaedic Surgery, Otto-von-Guericke University, Magdeburg, Germany
Search for more papers by this authorCorresponding Author
Christoph H. Lohmann
Department of Orthopaedic Surgery, Otto-von-Guericke University, Magdeburg, Germany
Correspondence to: C. H. Lohmann (e-mail: [email protected])Search for more papers by this authorAbstract
Two-stage exchange arthroplasty is the current standard of care for arthroplasty-related infections. Reinfection rates up to 30% are reported, and there is significant morbidity for the patient. In cases of failure, arthrodesis or amputation may result. Ultrasonic treatment has the potential to eradicate biofilms and avoid two-stage exchange arthroplasty. Data in the specific context of arthroplasty infections is scant, and there is debate regarding optimal frequency and intensity of treatment. Surface topography alterations of the endoprosthetic components and damage to adjacent bone and cartilage have not been investigated. We found incomplete biofilm eradication and significant increase in surface roughness (maximum peak-to-valley height) of cobalt-chrome unicondylar knee components as well as reduction in articular cartilage thickness area from 10 retrieved femoral heads after low-frequency sonication treatment according to manufacturer-specified recommendations. Our data collectively suggest that sonication treatment for biofilm eradication in arthroplasty infections may not be effective and surface topography alterations may potentially reduce implant longevity. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1835–1846, 2014.
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