Short and long gap peripheral nerve repair with magnesium metal filaments
Tracy M. Hopkins
Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267
Search for more papers by this authorKevin J. Little
Division of Pediatric Orthopaedics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, Ohio 45229
Search for more papers by this authorJohn J. Vennemeyer
Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267
Search for more papers by this authorJefferson L. Triozzi
Student Affairs, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267
Search for more papers by this authorMichael K. Turgeon
Student Affairs, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267
Search for more papers by this authorAlexander M. Heilman
Student Affairs, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267
Search for more papers by this authorD. Minteer
Department of Plastic Surgery, University of Pittsburgh, 3380 Boulevard of the Allies, Suite 138, Pittsburgh, Pennsylvania 15213
Search for more papers by this authorK. Marra
Departments of Plastic Surgery and Bioengineering, 1655E BST, University of Pittsburgh, 200 Lothrop St., Pittsburgh, Pennsylvania 15261
Search for more papers by this authorDavid B. Hom
Division of Facial Plastic & Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267
Search for more papers by this authorCorresponding Author
Sarah K. Pixley
Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267
Portions of this work have appeared previously in abstract and poster format
Correspondence to: Sarah Pixley; e-mail: [email protected]Search for more papers by this authorTracy M. Hopkins
Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267
Search for more papers by this authorKevin J. Little
Division of Pediatric Orthopaedics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, Ohio 45229
Search for more papers by this authorJohn J. Vennemeyer
Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267
Search for more papers by this authorJefferson L. Triozzi
Student Affairs, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267
Search for more papers by this authorMichael K. Turgeon
Student Affairs, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267
Search for more papers by this authorAlexander M. Heilman
Student Affairs, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267
Search for more papers by this authorD. Minteer
Department of Plastic Surgery, University of Pittsburgh, 3380 Boulevard of the Allies, Suite 138, Pittsburgh, Pennsylvania 15213
Search for more papers by this authorK. Marra
Departments of Plastic Surgery and Bioengineering, 1655E BST, University of Pittsburgh, 200 Lothrop St., Pittsburgh, Pennsylvania 15261
Search for more papers by this authorDavid B. Hom
Division of Facial Plastic & Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267
Search for more papers by this authorCorresponding Author
Sarah K. Pixley
Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267
Portions of this work have appeared previously in abstract and poster format
Correspondence to: Sarah Pixley; e-mail: [email protected]Search for more papers by this authorAbstract
A current clinical challenge is to replace autografts for repair of injury gaps in peripheral nerves, which can occur due to trauma or surgical interruption. Biodegradable metallic magnesium filaments, placed inside hollow nerve conduits, could support nerve repair by providing contact guidance support for axonal regeneration. This was tested by repairing sciatic nerves of adult rats with single magnesium filaments placed inside poly(caprolactone) nerve conduits. Controls were empty conduits, conduits containing titanium filaments and/or isografts from donor rats. With a nerve gap of 6 mm and 6 weeks post-repair, magnesium filaments had partially resorbed. Regenerating cells had attached to the filaments and axons were observed in distal stumps in all animals. Axon parameters were improved with magnesium compared to conduits alone or conduits with single titanium filaments. With a longer gap of 15 mm and 16 weeks post-repair, functional parameters were improved with isografts, but not with magnesium filaments or empty conduits. Magnesium filaments were completely resorbed and no evidence of scarring was seen. While axon outgrowth was not improved with the longer gap, histological measures of the tissues were improved with magnesium compared to empty conduits. Therefore, the use of magnesium filaments is promising because they are biocompatible and improve aspects of nerve regeneration. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3148–3158, 2017.
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