Alkyl chitosan film-high strength, functional biomaterials
Li Lu
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China
Department of Materials Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania, 16802
Department of Bioengineering, The Pennsylvania State University, University Park, Pennsylvania, 16802
Search for more papers by this authorCao Xing
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China
Search for more papers by this authorShen Xin
College of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China
Search for more papers by this authorYu Shitao
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China
Search for more papers by this authorSu Feng
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China
Search for more papers by this authorLiu Shiwei
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China
Search for more papers by this authorLiu Fusheng
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China
Search for more papers by this authorXie Congxia
Key Laboratory of Eco-Chemical Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China
Search for more papers by this authorLi Lu
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China
Department of Materials Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania, 16802
Department of Bioengineering, The Pennsylvania State University, University Park, Pennsylvania, 16802
Search for more papers by this authorCao Xing
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China
Search for more papers by this authorShen Xin
College of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China
Search for more papers by this authorYu Shitao
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China
Search for more papers by this authorSu Feng
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China
Search for more papers by this authorLiu Shiwei
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China
Search for more papers by this authorLiu Fusheng
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China
Search for more papers by this authorXie Congxia
Key Laboratory of Eco-Chemical Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China
Search for more papers by this authorThis article was published online on 14 August 2017. An error was subsequently identified in the article and was updated. This notice is included in the online and print versions to indicate this has been corrected on 14 December 2017.
Abstract
Biofilm with strong tensile strength is a topic item in the area of tissue engineering, medicine engineering, and so forth. Here we introduced an alkyl chitosan film with strong tensile strength and its possibility for an absorbable anticoagulation material in vivo was tested in the series of blood test, such as dynamic coagulation time, plasma recalcification time and hemolysis. Alkyl chitosan film was a better biomaterial than traditional chitosan film in the anticoagulation, tissue compatibility and cell compatibility. The unique trait of alkyl chitosan film may be for its greater contact angle and hydrophobicity ability to reduce the adsorption capacity for the blood component and the activity of fibrinolytic enzymes, enhance the antibacterial capacity than chitosan film. Moreover, none of chitosan film or butyl chitosan film exhibited quick inflammation or other disadvantage and degraded quickly by implanted test. Therefore, Alkyl chitosan film is of prospective properties as an implantable, absorbable agent for tissue heals, and this material need further research. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3034–3041, 2017.
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