A novel pH-responsive interpolyelectrolyte hydrogel complex for the oral delivery of levodopa. Part I. IPEC modeling and synthesis
Ndidi C. Ngwuluka
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa
Search for more papers by this authorYahya E. Choonara
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa
Search for more papers by this authorPradeep Kumar
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa
Search for more papers by this authorLisa C. du Toit
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa
Search for more papers by this authorRiaz A. Khan
Department of Chemistry, Manav Rachna International University, Aravali Hills, Faridabad, Haryana, India
Search for more papers by this authorCorresponding Author
Viness Pillay
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa
Correspondence to: V. Pillay; e-mail: [email protected]Search for more papers by this authorNdidi C. Ngwuluka
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa
Search for more papers by this authorYahya E. Choonara
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa
Search for more papers by this authorPradeep Kumar
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa
Search for more papers by this authorLisa C. du Toit
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa
Search for more papers by this authorRiaz A. Khan
Department of Chemistry, Manav Rachna International University, Aravali Hills, Faridabad, Haryana, India
Search for more papers by this authorCorresponding Author
Viness Pillay
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa
Correspondence to: V. Pillay; e-mail: [email protected]Search for more papers by this authorAbstract
This study was undertaken to synthesize an interpolyelectrolyte complex (IPEC) of polymethacrylate (E100) and sodium carboxymethylcellulose (NaCMC) to form a polymeric hydrogel material for application in specialized oral drug delivery of sensitive levodopa. Computational modeling was employed to proffer insight into the interactions between the polymers. In addition, the reactional profile of NaCMC and polymethacrylate was elucidated using molecular mechanics energy relationships (MMER) and molecular dynamics simulations (MDS) by exploring the spatial disposition of NaCMC and E100 with respect to each other. Computational modeling revealed that the formation of the IPEC was due to strong ionic associations, hydrogen bonding, and hydrophilic interactions. The computational results corroborated well with the experimental and the analytical data. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1077–1084, 2015.
REFERENCES
- 1 Vasile C, Bumbu GG, Petronela Dumitriu R, Staikos G. Comparative study of the behavior of carboxymethyl cellulose-g-poly(N-isopropylacrylamide) copolymers and their equivalent physical blends. Eur Polym J 2004; 40: 1209–1215.
- 2 Berger J, Reist M, Mayer JM, Felt O, Gurny R. Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications. Eur J Pharm Biopharm 2004; 57: 35–52.
- 3 Pergushov D, Remizova E, Zezin A, Kabanov V. Interpolyelectrolyte complex formation is possible in low-polarity organic media. Doklady Phys Chem 2006; 406: 38–42.
- 4 Nurkeeva ZS, Mun GA, Khutoryanskiy VV. Interpolymer complexes of water-soluble nonionic polysaccharides with polycarboxylic acids and their applications. Macromol Biosci 2003; 3: 283–295.
- 5 Mustafin R, Protasova A, Van dM, Kemenova V. Modification of chitosan by inclusion into interpolyelectrolyte complex with Eudragit L. Pharm Chem J 2006; 40: 325–328.
- 6 Moustafine RI, Zaharov IM, Kemenova VA. Physicochemical characterization and drug release properties of Eudragit® E PO/Eudragit® L 100-55 interpolyelectrolyte complexes. Eur J Pharm Biopharm 2006; 63: 26–36.
- 7 Abdelbary GA, Tadros MI. Design and in vitro/in vivo evaluation of novel nicorandil extended release matrix tablets based on hydrophilic interpolymer complexes and a hydrophobic waxy polymer. Eur J Pharm Biopharm 2008; 69: 1019–1028.
- 8 Hameed N, Guo Q. Nanostructure and hydrogen bonding in interpolyelectrolyte complexes of poly(ε-caprolactone)-block-poly(2-vinyl pyridine) and poly(acrylic acid). Polymer 2008; 49: 5268–5275.
- 9 LL Augsburger, SW Hoag, editors. Pharmaceutical Dosage Forms: Units Operations and Mechanical Properties. United Kingdom: Informa Health Care; 2008. 656 p.
- 10 Ammar HO, Khalil RM. Preparation and evaluation of sustained-release solid dispersions of drugs with eudragit polymers. Drug Dev Ind Pharm 1997; 23: 1043.
- 11 Margetson DN, Jones DS, Andrew G, McAllister MS. Physicochemical and drug release characteristics of quinine and polymers prepared by hot-melt extrusion. In: Basel, Switzerland, 20–21 June, 2007. p 1–6.
- 12 Zhao L, Mitomo H, Yosh F. Synthesis of pH-sensitive and biodegradable CM-cellulose/chitosan polyampholytic hydrogels with electron beam irradiation. J Bioact Compat Polym 2008; 23: 319–333.
- 13 Huangqin C, Mingwen F. Novel thermally sensitive pH-dependent chitosan/carboxymethyl cellulose hydrogels. J Bioact Compat Polym 2008; 23: 38–48.
- 14 Kumar P, Pillay V, Choonara YE, Modi G, Naidoo D, du Toit LC. In silico theoretical molecular modeling for Alzheimer's Disease: The nicotine-curcumin paradigm in neuroprotection and neurotherapy. Int J Mol Sci 2011; 12: 694–724.
- 15 Guo W, Guo Y, Gao H, Zheng Q, Zhong W. Energy dissipation in gigahertz oscillators from multiwalled carbon nanotubes. Phys Rev Lett 2003; 91: 125501.
- 16 Argüelles-Monal W, Gárciga M, Peniche-Covas C. Study of the stoichiometric polyelectrolyte complex between chitosan and carboxymethyl cellulose. Polym Bull 1990; 23: 307–313.
- 17 Devi N, Maji T. Study of complex coacervation of gelatin a with sodium carboxymethyl cellulose: Microencapsulation of neem (Azadirachta indica A. Juss.) seed oil (NSO). Int J Polym Mater 2011; 60: 1091–1105.
- 18 Yu BY, Chung JW, Kwak S. Reduced migration from flexible poly(vinyl chloride) of a plasticizer containing Î2-cyclodextrin derivative. Environ Sci Technol 2008; 42: 7522–7527.
- 19 Tiller AR, Gorella B. Estimation of polymer compatibility from molecular mechanics calculations. Polymer 1994; 35: 3251–3259.
- 20 Bawa P, Pillay V, Choonara YE, du Toit LC, Ndesendo VMK, Kumar P. A composite polyelectrolytic matrix for controlled oral drug delivery. AAPS PharmSciTech 2011; 12: 227–238.
- 21 Ndesendo VMK, Pillay V, Choonara YE, Du Toit LC, Meyer LCR, Buchmann E, Kumar P, Khan RA. In vivo evaluation of the release of zidovudine and polystyrene sulfonate from a dual intravaginal bioadhesive polymeric device in the pig model. J Pharm Sci 2011; 100: 1416–1435.
- 22 Tian Y, Li Y, Xu X, Jin Z, Jiao A, Wang J, Yu B. A novel size-exclusion high performance liquid chromatography (SE-HPLC) method for measuring degree of amylose retrogradation in rice starch. Food Chem 2010; 118: 445–448.
- 23 Abou-Rachid H, Lussier L, Ringuette S, Lafleur-Lambert X, Jaidann M, Brisson J. On the correlation between miscibility and solubility properties of energetic plasticizers/polymer blends: Modeling and simulation studies. Propellants Explosives Pyrotechnics 2008; 33: 301–310.
Citing Literature
