Review Article
Wound healing process and mediators: Implications for modulations for hernia repair and mesh integration
Emmanuel E. Sadava,
David M. Krpata,
Yue Gao,
Michael J. Rosen,
Yuri W. Novitsky,
Emmanuel E. Sadava
Case Comprehensive Hernia Center, Department of Surgery, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, Ohio 44106-5047
Search for more papers by this authorDavid M. Krpata
Case Comprehensive Hernia Center, Department of Surgery, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, Ohio 44106-5047
Search for more papers by this authorYue Gao
Case Comprehensive Hernia Center, Department of Surgery, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, Ohio 44106-5047
Search for more papers by this authorMichael J. Rosen
Case Comprehensive Hernia Center, Department of Surgery, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, Ohio 44106-5047
Search for more papers by this authorCorresponding Author
Yuri W. Novitsky
Case Comprehensive Hernia Center, Department of Surgery, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, Ohio 44106-5047
Correspondence to: Y. W. Novitsky; e-mail: [email protected]Search for more papers by this authorEmmanuel E. Sadava,
David M. Krpata,
Yue Gao,
Michael J. Rosen,
Yuri W. Novitsky,
Emmanuel E. Sadava
Case Comprehensive Hernia Center, Department of Surgery, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, Ohio 44106-5047
Search for more papers by this authorDavid M. Krpata
Case Comprehensive Hernia Center, Department of Surgery, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, Ohio 44106-5047
Search for more papers by this authorYue Gao
Case Comprehensive Hernia Center, Department of Surgery, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, Ohio 44106-5047
Search for more papers by this authorMichael J. Rosen
Case Comprehensive Hernia Center, Department of Surgery, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, Ohio 44106-5047
Search for more papers by this authorCorresponding Author
Yuri W. Novitsky
Case Comprehensive Hernia Center, Department of Surgery, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, Ohio 44106-5047
Correspondence to: Y. W. Novitsky; e-mail: [email protected]Search for more papers by this authorAbstract
In recent years, major advances have been accomplished in abdominal wall reconstruction. Introduction of newer prostheses have improved outcomes, but elimination of mesh-related morbidity is still an elusive issue. It is believed that host foreign body reaction to prosthesis plays an important role in the biology of these complications, so understanding of the molecular mechanisms behind mesh–tissue interactions may be a key for upcoming therapies. It appears that increasing biocompatibility of both synthetic prosthesis and biologic scaffolds might be the main avenues to achieve better outcomes. This manuscript provides an overview of major effectors of wound healing with particular emphasis on how their modulation might improve outcomes in tissue remodeling and mesh integration. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 295–302, 2014.
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