Lung cancer secreted microvesicles: Underappreciated modulators of microenvironment in expanding tumors
Marcin Wysoczynski
Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY
Search for more papers by this authorCorresponding Author
Mariusz Z. Ratajczak
Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY
Department of Physiology, Pomeranian Medical University, Szczecin, Poland
Fax: 502-852-3032.
University of Louisville, 500 South Floyd Street, Louisville, KY 40202, USASearch for more papers by this authorMarcin Wysoczynski
Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY
Search for more papers by this authorCorresponding Author
Mariusz Z. Ratajczak
Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY
Department of Physiology, Pomeranian Medical University, Szczecin, Poland
Fax: 502-852-3032.
University of Louisville, 500 South Floyd Street, Louisville, KY 40202, USASearch for more papers by this authorAbstract
Microvesicles (MVs) are shed from cell membranes of several cell types and have an important function in cell-to-cell communication. Exponentially growing lung cancer cells secrete large quantities of MVs and we were interested in their role in tumor progression. We observed that both human and murine lung cancer cell lines secrete more MVs in response to non-apoptotic doses of hypoxia and irradiation. These tumor-derived (t)MVs activate and chemoattract stroma fibroblasts and endothelial cells. Furthermore, they induce expression of several pro-angiopoietic factors in stromal cells such as IL-8, VEGF, LIF, OSM, IL-11 and MMP-9. We also noticed that conditioned media harvested from stroma cells stimulated by tMVs enhanced the metastatic potential of both human and murine lung cancer cells in vivo. Thus, we postulated that tMVs are underappreciated constituents of the tumor microenvironment and play a pivotal role in tumor progression, metastasis and angiogenesis. © 2009 UICC
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