Effect of soybean on breast cancer according to receptor status: A case–control study in Japan
Corresponding Author
Takeshi Suzuki
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan
Fax: +81-52-763-5233.
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, JapanSearch for more papers by this authorKeitaro Matsuo
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan
Department of Epidemiology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan
Search for more papers by this authorNobuyuki Tsunoda
Department of Breast Oncology, Aichi Cancer Center Hospital, Chikusa-ku, Nagoya, Japan
Search for more papers by this authorKaoru Hirose
Department of Planning and Information, Aichi Prefectural Institute of Public Health, Tsujimachi, Kita-ku, Nagoya, Japan
Search for more papers by this authorAkio Hiraki
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan
Search for more papers by this authorTakakazu Kawase
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan
Search for more papers by this authorToshinari Yamashita
Department of Breast Oncology, Aichi Cancer Center Hospital, Chikusa-ku, Nagoya, Japan
Search for more papers by this authorHiroji Iwata
Department of Breast Oncology, Aichi Cancer Center Hospital, Chikusa-ku, Nagoya, Japan
Search for more papers by this authorHideo Tanaka
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan
Search for more papers by this authorKazuo Tajima
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan
Department of Epidemiology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan
Search for more papers by this authorCorresponding Author
Takeshi Suzuki
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan
Fax: +81-52-763-5233.
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, JapanSearch for more papers by this authorKeitaro Matsuo
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan
Department of Epidemiology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan
Search for more papers by this authorNobuyuki Tsunoda
Department of Breast Oncology, Aichi Cancer Center Hospital, Chikusa-ku, Nagoya, Japan
Search for more papers by this authorKaoru Hirose
Department of Planning and Information, Aichi Prefectural Institute of Public Health, Tsujimachi, Kita-ku, Nagoya, Japan
Search for more papers by this authorAkio Hiraki
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan
Search for more papers by this authorTakakazu Kawase
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan
Search for more papers by this authorToshinari Yamashita
Department of Breast Oncology, Aichi Cancer Center Hospital, Chikusa-ku, Nagoya, Japan
Search for more papers by this authorHiroji Iwata
Department of Breast Oncology, Aichi Cancer Center Hospital, Chikusa-ku, Nagoya, Japan
Search for more papers by this authorHideo Tanaka
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan
Search for more papers by this authorKazuo Tajima
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan
Department of Epidemiology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan
Search for more papers by this authorAbstract
The possible association of high soy food consumption with low incidence of breast cancer in Asian countries has been widely investigated, but findings from epidemiologic studies have been inconsistent. Breast cancers defined by receptor status, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) may have distinct etiologic factors. Here, we conducted a case–control study to clarify associations between intake of soybean products and breast cancer risk according to receptor status. A total of 678 breast cancer cases and 3,390 age- and menopausal status-matched noncancer controls were included. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using conditional logistic models adjusted for potential confounders. On analysis according to receptor status, we observed a significantly reduced risk of ER-positive (ER+) (top tertile OR = 0.74; 95% CI, 0.58–0.94; trend p = 0.01) and HER2-negative (HER2−) tumors (top tertile OR = 0.78; 95% CI, 0.61–0.99; trend p = 0.04). Further, when the 3 receptors were jointly examined, a reduced risk was observed only in patients with ER+/PR+/HER2− tumor (top tertile OR = 0.73; 95% CI, 0.54–0.97; trend p = 0.03). These findings indicate that the protective effect of soy against breast cancer risk differs by receptor status. © 2008 Wiley-Liss, Inc.
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