Human Psychopharmacology: Clinical and Experimental

Research Article

Pharmacological, sensorimotor, and expectancy effects on tobacco withdrawal: a preliminary study

Corresponding Author

Casey R. Guillot

Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA

Correspondence to: C. R. Guillot, Department of Preventive Medicine, University of Southern California, 2001 N Soto St, SSB 3rd Floor, Los Angeles, CA 90032–9045, USA. Tel: 323-442-8218; Fax: 323-442-2359 E-mail: [email protected]Search for more papers by this author

Matthew D. Stone,

Matthew D. Stone

Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA

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Bree A. Geary,

Bree A. Geary

Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA

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Matthew G. Kirkpatrick,

Matthew G. Kirkpatrick

Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA

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Jennifer W. Tidey,

Jennifer W. Tidey

Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA

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Jessica W. Cook,

Jessica W. Cook

University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA

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Adam M. Leventhal,

Adam M. Leventhal

Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA

Department of Psychology, University of Southern California, Los Angeles, CA, USA

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Casey R. Guillot,

Corresponding Author

Casey R. Guillot

Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA

Matthew D. Stone,

Matthew D. Stone

Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA

Search for more papers by this author

Bree A. Geary,

Bree A. Geary

Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA

Search for more papers by this author

Matthew G. Kirkpatrick,

Matthew G. Kirkpatrick

Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA

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Jennifer W. Tidey,

Jennifer W. Tidey

Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA

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Jessica W. Cook,

Jessica W. Cook

University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA

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Adam M. Leventhal,

Adam M. Leventhal

Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA

Department of Psychology, University of Southern California, Los Angeles, CA, USA

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First published: 26 May 2015

https://doi.org/10.1002/hup.2484

Citations: 7

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Abstract

Objective

Research designs for parsing the mechanisms underlying tobacco withdrawal are scant. This study introduced a novel research design that simultaneously manipulated three tobacco withdrawal mechanisms: pharmacological (nicotine dissipation), sensorimotor (elimination of the smoking ritual), and expectancy (activation of beliefs regarding the effects of nicotine deprivation), permitting examination of the effects of each mechanism while holding the other two mechanisms constant.

Methods

Following overnight abstinence, 32 regular cigarette smokers were randomized in a 2 (expectancy: told patch contains nicotine versus told placebo patch) × 2 (drug: receive 21-mg transdermal nicotine patch versus receive placebo patch) × 2 (sensorimotor: smoke very low nicotine content cigarettes versus no smoking) full factorial between-subjects design. Participants repeatedly completed measures of craving, affect, and anticipated pleasure from and desire for rewarding experiences, followed by a smoking lapse analog task.

Results

Receiving nicotine (versus placebo) increased positive affect and anticipated pleasure from and desire for reward. Expecting nicotine (versus placebo) reduced negative affect and increased smoking delay. Sensorimotor stimulation from smoking (versus no smoking) reduced smoking urge and behavior.

Conclusion

Results provided initial validation of this novel three-mechanism design. This design can be used in the future to advance understanding and treatment of tobacco withdrawal. Copyright © 2015 John Wiley & Sons, Ltd.

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Volume30, Issue5

September 2015

Pages 364-371

Pharmacological, sensorimotor, and expectancy effects on tobacco withdrawal: a preliminary study

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Pharmacological, sensorimotor, and expectancy effects on tobacco withdrawal: a preliminary study

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